The present invention relates to the synthesis of rhodiola glycoside compound. Under the catalyst of boron trifluoride etherate, trifluoromethyl sulfonic acid, trialkylsilyl triflate, perchloric acid or other Lewis acid, 1-glycoimino ester and substituted phenyl ethanol as raw material react to produce polysubstituted rhodiola glycoside compound; and the polysubstituted rhodiola glycoside compound is reacted with hydroxide, carbonate or methoxide to produce rhodiola glycoside compound. The said process is simple, high in yield and suitable for industrial production.