3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of i karos family zinc finger 2 (IKZF2)-dependent diseases

[0524]Example 1: A compound of formula (I'), wherein:

[0525]X1And X2Each independently is H, (C1-C4)Alkyl, (C1-C6)Alkoxy, (C1-C4) Haloalkyl,

[0526](C1-C6)Haloalkoxy, (C3-C7) Cycloalkyl, halogen, CN, -OH, or -NH2;

[0527]RxIs H or D;

[0528]Each RaAnd RbIndependently H or D, or RaAnd RbTogether with the atoms to which they are attached, form = (O);

[0529]R1Yes

[0530]R2Is H, (C1-C6)Alkyl, (C1-C6)Haloalkyl, or (C3-C6) Cycloalkyl; or

[0531]R2And R7Together with the nitrogen atom to which they are attached to form a 6-membered or 7-membered heterocycloalkyl ring;

[0532]Each R3It is independently (C1-C6)Alkyl, (C1-C6)Alkoxy, (C1-C6)Haloalkyl, (C1-C6) Haloalkoxy, halogen, CN, -OH, or -NH2;or

[0533]Two R3Together with the carbon atoms to which they are attached (C3-C7) Cycloalkyl or 4- to 7-membered heterocycloalkyl ring, the heterocycloalkyl ring containing 1-3 heteroatoms selected from O, N and S; or when two R3When on adjacent carbon atoms together form a phenyl group, or a 5- or 6-membered heteroaryl

[0554]Embodiment 2: The compound as described in embodiment 1, which has formula (I), wherein:

[0555]RxIs H or D;

[0556]R1Yes

[0557]R2Is H, (C1-C6)Alkyl, (C1-C6)Haloalkyl, or (C3-C6) Cycloalkyl; or

[0558]R2And R7Together with the nitrogen atom to which they are attached to form a 6-membered or 7-membered heterocycloalkyl ring;

[0559]Each R3It is independently (C1-C6)Alkyl, (C1-C6)Alkoxy, (C1-C6)Haloalkyl, (C1-C6) Haloalkoxy, halogen, CN, -OH, or -NH2;or

[0560]Two R3Together with the carbon atoms to which they are attached (C3-C7) Cycloalkyl or 4- to 7-membered heterocycloalkyl ring, the heterocycloalkyl ring containing 1-3 heteroatoms selected from O, N and S; or when two R3When on adjacent carbon atoms together form a phenyl group, or a 5- or 6-membered heteroaryl ring, the heteroaryl ring contains 1-3 heteroatoms selected from O, N and S; or

[0561]R3And R7Together with the nitrogen and carbon atoms to which they are attached, a 5- or 6-membered heterocycloalkyl ring is formed, the heterocyc

[0579]Embodiment 3: The compound as described in embodiment 1 or 2, wherein R1Yes