3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of i karos family zinc finger 2 (IKZF2)-dependent diseases
A C1-C6, -NH2 technology, applied in the direction of medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., can solve problems such as excessive toxicity, difficulty in heterodimerization, and limited therapeutic utility
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Example Embodiment
[0524]Example 1: A compound of formula (I'), wherein:
[0525]X1And X2Each independently is H, (C1-C4)Alkyl, (C1-C6)Alkoxy, (C1-C4) Haloalkyl,
[0526](C1-C6)Haloalkoxy, (C3-C7) Cycloalkyl, halogen, CN, -OH, or -NH2;
[0527]RxIs H or D;
[0528]Each RaAnd RbIndependently H or D, or RaAnd RbTogether with the atoms to which they are attached, form = (O);
[0529]R1Yes
[0530]R2Is H, (C1-C6)Alkyl, (C1-C6)Haloalkyl, or (C3-C6) Cycloalkyl; or
[0531]R2And R7Together with the nitrogen atom to which they are attached to form a 6-membered or 7-membered heterocycloalkyl ring;
[0532]Each R3It is independently (C1-C6)Alkyl, (C1-C6)Alkoxy, (C1-C6)Haloalkyl, (C1-C6) Haloalkoxy, halogen, CN, -OH, or -NH2;or
[0533]Two R3Together with the carbon atoms to which they are attached (C3-C7) Cycloalkyl or 4- to 7-membered heterocycloalkyl ring, the heterocycloalkyl ring containing 1-3 heteroatoms selected from O, N and S; or when two R3When on adjacent carbon atoms together form a phenyl group, or a 5- or 6-membered heteroaryl
Example Embodiment
[0554]Embodiment 2: The compound as described in embodiment 1, which has formula (I), wherein:
[0555]RxIs H or D;
[0556]R1Yes
[0557]R2Is H, (C1-C6)Alkyl, (C1-C6)Haloalkyl, or (C3-C6) Cycloalkyl; or
[0558]R2And R7Together with the nitrogen atom to which they are attached to form a 6-membered or 7-membered heterocycloalkyl ring;
[0559]Each R3It is independently (C1-C6)Alkyl, (C1-C6)Alkoxy, (C1-C6)Haloalkyl, (C1-C6) Haloalkoxy, halogen, CN, -OH, or -NH2;or
[0560]Two R3Together with the carbon atoms to which they are attached (C3-C7) Cycloalkyl or 4- to 7-membered heterocycloalkyl ring, the heterocycloalkyl ring containing 1-3 heteroatoms selected from O, N and S; or when two R3When on adjacent carbon atoms together form a phenyl group, or a 5- or 6-membered heteroaryl ring, the heteroaryl ring contains 1-3 heteroatoms selected from O, N and S; or
[0561]R3And R7Together with the nitrogen and carbon atoms to which they are attached, a 5- or 6-membered heterocycloalkyl ring is formed, the heterocyc
Example Embodiment
[0579]Embodiment 3: The compound as described in embodiment 1 or 2, wherein R1Yes
PUM
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Abstract
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Application Information
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