208results about "Organic compound preparation" patented technology

The invention discloses a phenol ortho-methylation catalyst and a preparation method thereof. The catalyst is an alkaline Fe/Mg compound oxide, wherein, the mol ratio of Fe to Mg is 1: (0.1-2). The preparation method comprises the following steps: mixing and dissolving soluble malysite and soluble magnesium salts into alcohols solvent according to a required proportion to prepare a solution A; adding polyethyleneglycol (PEG) into strong aqua ammonia to prepare a solution B; slowly mixing the solution A and the solution B in a cocurrent flow mode under the condition of normal temperature and ultrasound, and then going on with the ultrasound for 30 minutes; filtering, washing, drying and baking the obtained precipitation; porphyrizing the baked solid and repulverizing the solid into 10-20 mesh finely ground particles after tabletting; the finely ground particles are the catalyst. The catalyst has the advantages of high activity at low temperature, simple preparation, innocuity, good stability, high selectivity of ortho position, particularly high selectivity of orthocresol and few by-products.

The present invention provides a method for recovering a natural gas contaminated with high levels of carbon dioxide. A gas containing methane and carbon dioxide is extracted from a reservoir containing natural gas, where carbon dioxide comprises at least 50 vol. % of the extracted gas. The extracted gas is oxidized with an oxygen containing gas in the presence of a partial oxidation catalyst at a temperature of less than 600° C. to produce an oxidation product gas containing hydrogen, carbon monoxide, and carbon dioxide. The oxidation product gas is then utilized to produce a liquid hydrocarbon or a liquid hydrocarbon oxygenate.

The invention relates to a method for purifying citrulline from a watermelon, which comprises the following steps: removing the pulp of a citrulline, carrying out ultrasonic extraction twice to three times with acid water, settling impurities with a settling agent, purifying citrulline with macroporous resin columns and strong-acid cation resin columns in series, eluting with ammonia water, carrying out concentrative crystallization, dissolving roughly crystallized substances with acid water, adjusting the pH with ammonia water, recrystallizing and the like. The method has the advantages of high extraction efficiency, low energy consumption and high product purity.

The invention discloses a method for preparing a 2-iodine amyl -2-ene-1,4-diketone derivative by adopting visible light catalysis. The method comprises the steps of adding allene, perfluorobutyl iodide, an additive and a photocatalyst as shown in a formula (I) to an organic solvent at the molar ratio of 1:(1-2):(1-2):(0.005-0.1), stirring under the conditions of an oxygen atmosphere, visible light illumination, room temperature and ordinary pressure for 10-20h, carrying out post-treatment on a reaction liquid to obtain a 2-iodine amyl -2-ene-1,4-diketone derivative as shown in a formula (II), wherein the additive is NaI, NH4I or KI; the organic solvent is ethanol, dichloromethane, benzene, methylbenzene, tetrahydrofuran or acetonitrile; the photocatalyst is selected from one of the following components: Ir(ppy)3, Eosin Y, Rose Bengal, [Ir(dF-CF3-ppy)2(dtbbpy)]PF6, [Ir(ppy)2(tbbpy)]PF6, Ru(bpy)3(BF4)2. The method is mild in reaction condition, simple in operation, high in selectivity and good in yield; a substituent group can be expanded; and visible light catalysis is adopted, so that the method has the characteristics of being free of pollution and environment-friendly. The formulas are as shown in the specification.

The present invention refers to the use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, which have important activities in increasing the gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-α levels and an exogenous source of nitric oxide. More particularly, the present invention describes the use of such phthalimide and/or sulphonamide derivatives for the treatment of sickle-cell disease. The invention also has as a novel characteristic the disclosure of new functionalized phthalimide derivatives designed from the prototypes thalidomide and hydroxyurea, and designed rationally through the strategy of molecular hybridization for the treatment of said diseases. The invention still discloses a new method for obtaining a specific sulphonamide derivative which can be used in the preparation of a drug for the treatment of diseases which require reducing the levels of the TNF-α factor and an exogenous source of nitric oxide.

The invention relates to esterification catalyst, which is inorganic compound including ionic liquid and inorganic compound with Lewis acid. The cation of the ionic liquid is imidazole or pyridine taken place by C1C15 alkyl, wherein, the substituting group number is one or more, and the anion is BF4<-> or PF6<->; the inorganic compound with Lewis acid is selected from FeCl3, SnCl4, ZnCl2 or Zn (NO32) and so on, and the mol ratio of the inorganic compound with Lewis acid and the ionic liquid is 0.01 to 1.0:1. The catalyst is used for esterification reaction, the selectivity is good, the yield rate of the esterified ester is high, and the service life is long.

The invention relates to a method for preparing solid base catalyst with high specific surface by hybrid composite precursors, belonging to the technical field of preparation of composite metal oxide. The method comprises the following steps of: according to the characteristics of designability in structure and adjustability in laminate composition of laminated composite metal hydroxide, introducing a certain amount of Mg and Al, or Ca, Cu, Co, In and Ga on the laminate, preparing laminated compound, obtaining hybrid composite precursors by hybridization with carbon, then conducting high-temperature roasting on the precursors and obtaining the solid base catalyst of composite metal oxide with high specific surface and mesoporous structure. Due to introduction of the carbon into the precursors, the composite metal oxide obtained by the method has the characteristics of narrow pore size distribution and large specific surface area and the like, and the application of the catalyst in Knoevenagel condensation reaction of benzaldehyde and ethyl cyanoacetate shows good base catalytic activity.

The invention discloses a preparation method of environment-friendly type alpha-cyanoacrylate, which takes cyanoacetates and formaldehyde or paraformaldehyde as raw materials, under existence of a basic catalyst, an organic solvent which enables azeotropy with water can be taken as a dehydrant, then a condensation reaction is carried out, after completely dehydrating, an environment-friendly type plasticizer, an anionic polymerization inhibitor and an environment-friendly type free radical polymerization inhibitor are added for cracking, and then are rectified to obtain the alpha-cyanoacrylate monomer. The preparation method of the present invention selects the organic solvent for azeotropy and dehydration, the environmental protection plasticizer and the polymerization inhibitor are employed during the cracking process, then the environment-friendly type alpha-cyanoacrylate can be obtained with high yield, and the preparation method is suitable for field with high requirement on environmental protection.

The invention relates to a method for recycling methylal in glyphosate wastewater. The method comprises the following steps of: 1) treating the chloromethane tail gas obtained by deacidifying the glyphosate through a dealcoholization kettle with three-stage condensation and multi-stage washing in a water scrubber, wherein the chloromethane gas enters into a compression system so as to be recycled, and the condensate enters into a dilute methyl alcohol storage tank; pumping the condensate in the dilute methyl alcohol storage tank into a preheating kettle with the temperature of 50-60 DEG C to preheat the dilute methyl alcohol for 10-15min, then, distilling the preheated dilute methyl alcohol in a distillation tower; distilling out the low-boiling point methylal from the top of the distillation tower, discharging after reflowing and condensing, and conveying the condensate into a collection tank. The method not only can effectively reduce the potential safety hazards caused by wastewater discharge, but also can effectively recycle the methylal, and can improve the recovery rate of the methylal to be more than 96%.

The invention discloses a 2-amino-4-acetamino anisole synthesis process. The process comprises the following steps that in methyl alcohol, 2,4-diaminobenzene methyl ether (III) and acetic anhydride are subjected to an acylation reaction as follows under the effect of an acid-binding agent to obtain 2-amino-4-acetamino anisole (IV), wherein the mole ratio of the acid-binding agent to the 2,4-diaminobenzene methyl ether is 0.3:1-0.6:1. The synthesis process is low in energy consumption, low in cost, small in amount of solid waste and liquid waste, free of pollution, environmentally friendly, easy to operate, mild in reaction condition and high in industrial safety coefficient, the target compound yield is 86% or above (based on initial reaction raw materials), the HPLC purity is 99.0% or above, and the target compound is high in yield, good in quality, and more applicable to industrial production.

The invention discloses a coproduction method of 1, 2-propanediamine and dimethyl piperazine, which comprises the following steps of: mixing ammonia and isopropanol amine, pre-heating for vaporization, filling steam into a fixed-bed reactor, performing reaction in the presence of a catalyst for condensation and amination and under conditions with the pressure of 1.0MPa to 4.0MPa, the temperature of 300 DEG C to 350 DEG C and the contact time of 1.0-3.0s to obtain product stream of 1, 2-propanediamine, 2, 5-dimethyl piperazine, 2, 6-dimethyl piperazine, unreacted ammonia and unreacted isopropanol amine, and distilling the product stream for separation to obtain the 1, 2-propanediamine, 2, 5-dimethyl piperazine and 2, 6-dimethyl piperazine; wherein the weight ratio of the ammonia and the isopropanol amin is (10-16):1, and the catalyst for condensation and amination comprises the following ingredients by weight percentage: 97-99 percent of HZSM-5 (H-type zeolite sieve of molecular porosity 5) zeolite and 1-3 percent of phosphorus. The coproduction method is mainly applied in preparation of the 1, 2-propanediamine and the dimethyl piperazine.

The invention discloses a separation method used for preparing isopropanol via hydrogenation of acetone. According to the separation method, an acetone hydrogenation product is subjected to azeotropic distillation and extractive distillation so as to obtain high-purity isopropanol. The separation method comprises following steps: (1) the acetone hydrogenation product is delivered into a rectifying tower for azeotropic distillation, an azeotrope is collected from the top of the rectifying tower, a heavier component is collected from a tower kettle of the rectifying tower, and an isopropanol product is collected from side lines of a tower body of the rectifying tower; (2) the azeotrope collected from the top of the rectifying tower is delivered into a recovery tower, and is subjected to extractive distillation using an extraction agent, a material flow containing acetone and isopropanol is collected from the top of the recovery tower, and is delivered back to a reactor for recycling, and an aqueous solution rich in the extraction agent is collected from a tower kettle of the recovery tower; and (3) the aqueous solution rich in the extraction agent is delivered into a dehydrating tower, and the extraction is collected from a tower kettle of the dehydrating tower, and is delivered back to the recovery tower. According to the separation method, azeotropic distillation and extractive distillation are adopted, high-purity isopropanol is prepared, raw material consumption is less, extraction agent loss is low, technical processes are simple, and operation is convenient.

In a process for the production of urea, substantially pure ammonia and carbon dioxide are reacted in a reaction space (1) from which comes out a reaction mixture subjected to stripping (2) to obtain a partially purified mixture sent to a urea recovery section (3, 4, 7, 8). From the recovery section (3, 4, 7, 8) it is obtained a dilute carbamate solution, which is subjected to stripping (9) with recycling of vapors to the reaction space (1) after condensation (6). This process achieves high conversion yield with reduced energy consumption and low implementation costs.

The invention provides a simple method for extracting natural taurine from abalone viscera. The invention is characterized by comprising the following steps: raw material pretreatment: adding 2 times of weight-to-volume ratio of water into abalone viscera, boiling at high temperature, and collecting the soup; activated carbon treatment: passing the soup through an activated carbon column at room temperature to obtain an effluent liquid; removing impurities with ethanol, and centrifuging to obtain a precipitate and a supernatant; concentrating the supernatant to obtain a concentrated solution; adding anhydrous ethanol into the concentrated solution, standing at 4 DEG C, centrifuging to obtain a precipitate, dissolving the precipitate in hot water, adding activated carbon, stirring, and carrying out vacuum filtration to remove the activated carbon, thereby obtaining a filtrate; crystallizing to obtain a taurine crystal; and carrying out recrystallization one or more times as required. The invention has the advantages of simple technique, low extraction cost, high extraction rate, energy saving and environmental protection. The method provided by the invention can effectively utilize abalone processing byproducts and enhance the utilization ratio of ocean resources. The ethanol used in the method can be recycled, thereby being beneficial to industrialized production.

In one embodiment, the invention is to a process for producing acrylic acid, comprising the step of providing from a distillation column in a carbonylation process a purified acetic acid stream comprising at least 0.15 wt % water. The process further comprises the step of condensation acetic acid of the purified acetic acid stream and an alkylenating agent in the presence of a catalyst and under conditions effective to form a crude acrylate product comprising acrylic acid and water. Acrylic acid is recovered from the crude acrylate product.

The present invention relates to a novel nickel catalyst. The present invention also relates to a process for the preparation of an improved nickel catalyst. The present invention also relates to a process for hydrogenation of m-dinitro benzene to m-phenylene diamine using the said improved catalyst. More particularly the present invention relates to a process involving hydrogenation of m-dinitrobenzene to m phenylene diamine in the presence of a supported bimetallic platinum catalyst, using methanol as a solvent. The catalyst system consisting of one metal selected from platinum group and other nickel supported on either carbon or alumina or silica or zeolite. The catalyst of the present invention is a bimetallic catalyst prepared by precipitation and impregnation technique at very specific preparation conditions.

The invention discloses a high-shear reactor with a feed distribution device. The high-shear reactor comprises a reactor shell, wherein a first feed pipe is arranged on the top wall of the reactor shell; a stator substrate is arranged on the inner surface of the lateral wall of the reactor shell; stator gear rings are arranged on the lower surface of the top wall of the reactor shell and the lower surface of the stator substrate; a main transmission shaft is arranged along the central line of the reactor shell; a rotor substrate is arranged on the main transmission shaft; a rotor gear ring is arranged on the upper surface of the rotor substrate; the stator gear rings and the rotor gear ring are engaged with each other; a discharge port is arranged on the lower end of the reactor shell; the inner surface of the innermost gear ring of a primary stator gear ring is fixedly connected on the periphery of the feed distribution device which is connected with a second feed pipe; and the second feed pipe passes through and is arranged on the top wall of the reactor shell. The reactor is suitable for a quick reaction system by which solid can be generated, can prevent quick growth of solid particles from plugging the reactor, and is particularly suitable for preparing organic isocyanate.

An anti-reflective coating composition is provided. The anti-reflective coating composition of the present invention can be useful in preventing a pull-back phenomenon in which an anti-reflective coating layer tears on a corner of a pattern of a substrate during a heat curing process and improving gap-filling performance of the pattern since a crosslinker is attached to a polymer in the composition and the content of the low-molecular-weight crosslinker in the composition is minimized to regulate a heat curing initiation temperature.

The invention discloses a process for producing arginine by microbial fermentation. Brevibacterium flavum MQA121 is adopted. The method comprises the following steps: preparing fermentation liquid, namely performing slant culture, performing shake-flask culture, performing primary seed culture, performing secondary seed culture, and continuing to ferment; extracting and refining a fermented product, namely preprocessing the fermentation liquid, performing secondary crystallization, performing color and impurity removal, performing membrane concentration and separation, drying, and packaging to obtain arginine as a finished product. The method has the benefits that organic and inorganic matters and bacteria in subsequent extracting and refining liquid of arginine can be remarkably reduced and the arginine yield can be increased; in addition, the product quality is improved and the production cost is reduced.