69 results about "Polyethylene glycol" patented technology

An electrically controlled propellant comprising an ionomer oxidizer polymer binder, an oxidizer mix including at least one oxidizer salt and at least one eutectic material, and a mobile phase comprising at least one ionic liquid is disclosed. The PVAN polymer in the present invention may be of medium (>100,000) to high molecular weight (<1,000,000). The present invention also may include the controlled cross-linking of the polymer using epoxy resins, the use of moisture barrier coating, the addition of an energetic combustion additives such as Chromium III and polyethylene glycol polymer.

The invention belongs to the technical field of polymer preparation, and especially relates to a preparation method of a thermoplastic polyurethane elastomer. The method comprises the following steps: 1, putting 1,4-cyclohexyl diisocyanate, polyethylene glycol adipate, 1,4-butylene glycol, a lubricant and a hydrolysis resistance agent in a blender, fully stirring, and fully plastifying in a high-temperature plastifying machine or a high-temperature internal mixer to obtain a thermoplastic polyurethane elastomer matrix; 2, processing an inorganic nanofiller by a silane coupling agent to obtain an modified inorganic nanofiller; and 3, dissolving the thermoplastic polyurethane elastomer matrix in tetrahydrofuran, adding the modified inorganic nanofiller, mechanically stirring, removing tetrahydrofuran, and carrying out film forming to obtain the thermoplastic polyurethane elastomer. Compared with the prior art, the method provided by the invention can effectively increase the heat resistance, the mechanical performances and the ageing resistance of the polyurethane elastomer on the premise that the comprehensive performances of the thermoplastic polyurethane elastomer do not decrease.

The invention discloses a phenol ortho-methylation catalyst and a preparation method thereof. The catalyst is an alkaline Fe/Mg compound oxide, wherein, the mol ratio of Fe to Mg is 1: (0.1-2). The preparation method comprises the following steps: mixing and dissolving soluble malysite and soluble magnesium salts into alcohols solvent according to a required proportion to prepare a solution A; adding polyethyleneglycol (PEG) into strong aqua ammonia to prepare a solution B; slowly mixing the solution A and the solution B in a cocurrent flow mode under the condition of normal temperature and ultrasound, and then going on with the ultrasound for 30 minutes; filtering, washing, drying and baking the obtained precipitation; porphyrizing the baked solid and repulverizing the solid into 10-20 mesh finely ground particles after tabletting; the finely ground particles are the catalyst. The catalyst has the advantages of high activity at low temperature, simple preparation, innocuity, good stability, high selectivity of ortho position, particularly high selectivity of orthocresol and few by-products.

The invention discloses a double-tail four-functional hydrophilic UV (Ultraviolet) coating hardness assistant and a preparation method thereof. The preparation method comprises the following steps: firstly, reacting polyethylene glycol monomethyl ether, isocyanate and one-generation hyperbranched polymer to form a prepolymer I, and subsequently reacting a prepolymer obtained after crylic acid monomer is reacted with isocyanate with the prepolymer I, thereby preparing the double-tail four-functional hydrophilic UV coating hardness assistant. According to the preparation method, high-functionality hyperbranched molecules are adopted as primary reaction materials, the characteristics that the hyperbranched molecules are high in functionality but low in viscosity are taken, when the prepared hardness assistant is added into an aqueous UV resin, not only is the problem that a coating is always low in curing property but high in viscosity solved, but also the water solubility of the UV resin is improved, the hardness of the aqueous UV resin is also improved, and the application range of the aqueous UV resin is widened. When non-ionic polyethylene glycol methyl ether is connected to molecules, therefore the acid-alkali resistance of the coating is improved, an emulsion system is well stabilized, and experiment shows that the effect is good.

Ultrahigh-toughness concrete and a preparing method thereof are disclosed. The concrete is prepared from, by weight, 380-580 parts of cement, 150-170 parts of slag powder, 250-380 parts of fly ash, 200-400 parts of quartz sand, 13-15 parts of bamboo wood phenolic alcohol liquified resin, 13-18 parts of polypropylene resin, 0.5-1.5 parts of carboxymethylcellulose, 23-47 parts of core-shell acrylic acid elastic emulsion, 5-10 parts of a chemical-resistant modifier, 14-18 parts of bamboo fibers, 2.5-8.5 parts of nanometer silicon particles, 7-13 parts of nanometer calcium carbonate, 3-5 parts of anionic polyacrylamide, 3.7-8.3 parts of poly(diallyldimethylammonium chloride), 0.4-1 part of poly(ethylene glycol) acrylate, 20-30 parts of an acrylic emulsion, and the like. The ultrahigh-toughness concrete has high tensile strength, high compressive strength, ultrahigh ductility, good energy consumption capacity and good elastic modulus.

The invention relates to super-hydrophobic film materials and provides a super-hydrophobic polypropylene film and a preparation method thereof. The super-hydrophobic polypropylene film is characterized in that an isotactic polypropylene-b-polyethylene glycol diblock copolymer serves as a surface modifier to construct a micronano composite structure on the surface of the polypropylene film. The preparation method includes steps: dissolving the isotactic polypropylene-b-polyethylene glycol diblock copolymer in an alkane solvent to obtain a polymer solution, coating to the surface of the polypropylene film by spin coating, putting the polypropylene film subjected to surface modification into a vacuum drying oven, and performing vacuum drying to obtain the super-hydrophobic polypropylene film. The super-hydrophobic polypropylene film and the preparation method thereof have advantages that simplicity in operation is achieved, complex chemical treatment is avoided, and expensive equipment is not needed; the preparation method is high in efficiency, feasible, environment friendly, low in cost and easy for industrialization; the prepared super-hydrophobic polypropylene film has excellent surface structural stability.

The invention provides an anti-aflatoxin general type monoclonal antibody hybridoma cell line and application thereof, belonging to the field of food safety immunodetection. The cell line 1G6 provided by the invention is collected in the China General Microbiological Culture Collection Center (CGMCC) with a collection number of CGMCC No.7210. After an aflatoxin complete antigen is uniformly mixed with equivalent Quick Antibody immunologic adjuvant TM, an obtained mixture is injected to immunize BALB/c mice through leg muscle. B1-KLH (fumonisin B1-Keyhole Limpet Hemocyanin) is adopted for the first time of immunization, M1-KLH (fumonisin M1-Keyhole Limpet Hemocyanin) is adopted for the second time of immunization, and an M1 complete antigen (without containing adjuvant) is adopted for the last time of impaction immunization. Splenocytes of immunized mice are fused with myeloma cells through a PEG (polyethylene glycol) method, and the hybridoma cell line 1G6 is obtained through indirect ELISA (Enzyme-Linked Immuno Sorbent Assay) and indirect competence ELISA screening and three times of subcloning. A monoclonal antibody secreted from the cell line has better affinity and detection sensitivity for aflatoxins B1, B2, G1, G2 and M1, and can be used for immunodetection of the total quantity of the aflatoxins in the food safety.

The recombinant human interferon modified by polyethylene glycol is characterized by that on the recombinant human interferon one or two or more than two polyethylene glycol chains can be connected, said recombinant human interferon can be interferon alpha 2b, and the average degree of polymerization of said polyethylene glycol chain is 45-230. Said invented recombinant human interferon has the physiological activity of the interferon, and its stability is superior to that of interferon, its plasma clearance is low, the half-life period in vivo is long, it can be used for preparing the medicines for resisting virus and resisting cancer. Said invention also discloses its preparation method.

The invention discloses an oxygen-fluorine liposome microbubble therapeutic agent which consists of microbubbles, and oxygen and at least one perfluocarbon existing in the microbubbles, wherein the gas nucleus takes oxygen as a principle component and takes perfluocarbon as an auxiliary component, and the microbubble mainly consists of phospholipid and polyethylene glycol derivative. According to the oxygen-fluorine liposome microbubble therapeutic agent, oxygen can be controlled to be released in a human body through veins delivery and targeted hypoxia tissue under ultrasound wave irradiation, the hypoxia disease is treated, and the therapeutic agent serves as a contrast agent used for ultrasonic enhanced imaging. Therefore, the microbubble is a developing agent and an oxygenating therapeutic agent.

The invention provides a polyethylene glycol-polyamide-amine-polyamino acid linear-dendritic block polymer with a structure shown as a formula I, II, III or IV. The polyethylene glycol in the block polymer can be used for improving the biocompatibility of the block polymer and prolonging the circulation time of the block polymer in the blood, and a polyamino acid block can be used for ensuring the favorable degradation performance of a product and can be discharged in vitro after being degraded in vivo. The block polymer provided by the invention is simple in preparation method and safe and nontoxic in product. The block polymer is used as a carrier and assembled in water to form nanoparticles, and a model drug adriamycin is carried, so that drug-carried nanoparticles are obtained, and the drug-carried nanoparticles have a certain controlled-release function and can be used for effectively inhibiting the proliferation of cancer cells in cell experiments. Therefore, the block polymer has the potential application as a nano-drug carrier.

The invention provides a preparation method of a corrosion inhibitor of methanol gasoline, and belongs to the technical field of metal corrosion protection. The preparation method comprises steps as follows: alpha-methylstyrene dimer, maleic anhydride, dicumyl peroxide and dimethylbenzene are added into a reactor, and then, the mixture is heated in an atmosphere of nitrogen for reacting; after the mixture is cooled to the room temperature, octadecanol, polyethylene glycol, p-toluenesulfonic acid, n-butyl alcohol and ethyl acetate are added, the mixture is heated for reacting and then cooled to the room temperature, and a mixture I is obtained; the mixture I is washed with a sulfuric acid aqueous solution, then washed with an NaOH aqueous solution and finally washed with an aqueous solution, and a mixture II is obtained; and benzotriazole, 2, 6-tert-butyl-4-methyl phenol, hexamethylene tetramine, ethanol, propargyl alcohol, trimellitate, a surface active agent and a combustion improver are added into the mixture II and uniformly stirred, and the corrosion inhibitor is obtained. The provided methanol gasoline has good solubility with various oils, the additive amount is small, and the corrosion-resistant effect is superior to that of a similar product.

The invention discloses a thermoplastic starch-polyvinyl alcohol composite plastic film, and relates to the technical field of film production. The composite plastic film is made by using the following raw materials, by mass, 80-100 parts of (self-made) thermoplastic starch, 40-55 parts of polyvinyl alcohol, 10-15 parts of acrylic acid, 5-10 parts of benzoyl peroxide, 7-12 parts of oxidized polyethylene wax, 4-8 parts of hydroxyethyl cellulose, 5-12 parts of calcium stearate, 5-15 parts of iron oxide, 3-6 parts of gelatin, 5-10 parts of urea, and 8-15 parts of polyethylene glycol. The composite plastic film made in the invention reserves the good biodegradation performance of starch and effectively improves the mechanical performances of a plastic film, and a covalent bond introduced due to the addition of a cross-linking agent can substitute a hydrogen bond in order to improve the mutual crosslinking among starch, polyvinyl alcohol and other raw material molecules.

A method for storing and using platelets and an associated platelet structure. At least one modified platelet is formed. Each modified platelet includes a platelet and at least one polymerated chemical. Each polymerated chemical includes a polymer covalently bonded directly to the platelet or includes the polymer and a linker molecule such that the linker molecule is covalently bonded to the platelet and the polymer is covalently attached to the linker molecule. The polymer of each polymerated chemical of each modified platelet is polyethylene glycol (PEG) or a PEG derivative. Forming each modified platelet does not include modifying the platelet membrane of each platelet with a glycan-modifying agent. The at least one modified platelet is stored in a temperature range below 20° C. for at least one hour. After being stored, the at least one modified platelet may be introduced into a mammal.

The invention discloses a preparation method of zif-8 nanosphere loaded SERS coded gold nanoparticles for intracellular photothermal therapy. The preparation method comprises the following specific steps: (1) reacting chloroauric acid with trisodium citrate to generate 13nm gold nanoparticles; (2) labeling gold nanoparticles by using a Raman reporter DTTC, and adding sulfydryl-containing polyethylene glycol to stabilize the gold nanoparticles; (3) adding polyethylene glycol with a sulfydryl group at one end and a carboxyl group at the other end into (2), modifying the surfaces of the gold nanoparticles with a large amount of carboxyl groups, adding adriamycin and an activating agent, and reacting the materials for 24 hours to obtain drug-loaded gold nanoparticles; and (4) dispersing the drug-loaded gold nanoparticles in the step (3) into zinc nitrate and ligand dimethylimidazole, and reacting the materials to obtain the zif-8 nanosphere loaded SERS coded gold nanoparticles. The SERS coded drug-loaded nanoparticles prepared by the invention can be used for inhibiting cell transfer and intracellular photothermal therapy, and the drug is loaded on the surfaces of the gold nanoparticles to realize internalization of the drug and kill cancer cells to the maximum extent.

The invention discloses a method for strengthening joint stability by using an rhBMP-2 release coating on the surface of an artificial joint, which relates to a method for strengthening the joint stability. The invention solves the problem that a function of inducing the bone formation of BMP-2 is difficult to realize in the whole process of forming a new bone by using a method of combining an HA coating and the BMP-2 on the surface of the traditional artificial joint, and the action time of the release is not controllable by using a method of combining the BMP-2 and polyethylene glycol. The method comprises the following steps of: 1, adding EC and PEG 4000 into chloroform, ultrasonically dissolving the EC and PEG 4000, adding BMP-2 and carrying out ultrasonic dispersion to obtain a BMP-2 mixed liquid; and 2, spraying the BMP-2 mixed liquid on an artificial thighbone steam, placing the artificial thighbone steam in an ultra-clean working table to air, packaging into a seal bag, and sterilizing the seal bag at a low temperature to complete the process. The invention has the advantages of even and tight combination of the rhBMP-2 release coating and the joint surface, smooth coating layer, difficult damage, strengthened stability of the artificial joint and adjustable release performance.

The invention belongs to the technical field of solid electrolyte membranes for all-solid-state lithium batteries, and particularly relates to an application of a functionalized quantum dot compositesolid electrolyte membrane to the field of the all-solid-state lithium batteries. The functionalized quantum dot composite solid electrolyte membrane is prepared by selecting polyethylene oxide (PEO)as a polymer matrix, performing co-mixing and microwave-assisted reaction on polyethylene glycol diglycidyl ether (PEGDGE), diethylenetriamine and a citric acid aqueous solution to prepare PEGDGE functionalized carbon quantum dots as fillers, co-mixing PEGDGE functionalized carbon quantum dot dispersion liquid, Lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) and the PEO to prepare a membrane casting solution, and performing a casting method. The prepared functionalized quantum dot composite solid electrolyte membrane shows more excellent lithium ion conductivity and mechanical property compared with a traditional PEO electrolyte membrane.

The invention discloses a preparation method for dihydrosafrole. Piperidine and propionyl chloride are used as initial raw materials, and the preparation method comprises the following steps of: 1) acylation reaction of Friedel-crafts of the piperidine: reacting the piperidine and the propionyl chloride in a solvent I under the catalytic action of a lewis acid catalyst, adding iced water after finishing the reaction, standing, separating phases, washing an organic phase in the lower layer and distilling the solvent I to obtain piperonyl ethyl ketone; and 2) reduction reaction of Wolff-Kishner-Huang-min-lon of the piperonyl ethyl ketone: refluxing the piperonyl ethyl ketone and hydrazine hydrate solution at the mass concentration of 80 to 90 percent in a solvent II for hydrazone reaction, and adding polyethyleneglycol-400 and potassium hydroxide and performing hydrazone decomposing reaction to obtain the dihydrosafrole. The method for preparing the dihydrosafrole has the characteristics of high product yield rate, mild process condition, simple operation and the like.

Polyol and fatty acid is reacted under the catalysis of metal oxide to obtain polyol fatty acid ester. The polyol is glycol or polyglycol; the fatty acid is lauric acid, palmitic acid, stearic acid, oleic acid, etc.; and the esterification catalyst is metal oxide. The production process is simple, reliable and stable. During the process, the metal oxide is first reacted with fatty acid to produce fatty acid soap, and the fatty acid soap then catalyzes the esterification. The reaction is completed under the homogeneous phase condition and the fatty acid soap, normally as the processing assistant for rubber, needs no separation from the product. The product of the present invention is used as dispersant for mixing rubber to raise the inherent quality and outer appearance of rubber product.

The invention discloses a lung cancer and breast cancer treatment compound preparation containing active ingredients of traditional Chinese medicine and a preparation method of the lung cancer and breast cancer compound preparation. The lung cancer and breast cancer treatment compound preparation is made from erianin, taxol, bufalin and bruceine D according to a certain weight ratio. According to the preparation method, liposomes are prepared according to an ethyl alcohol injection method or dropping pills are prepared by taking polyethylene glycol as a base material to obtain the lung cancer and breast cancer treatment compound preparation containing the active ingredients of the traditional Chinese medicine. The form of the compound preparation is compound liposomes and compound dripping pills. According to animal in-vivo anticancer pharmacological experiments, the lung cancer and breast cancer treatment compound preparation containing the active ingredients of the traditional Chinese medicine has obvious inhibiting effect on growth of lung cancer and breast cancer and has higher anticancer activity than chemotherapeutic drug 5-fluorouracil.

Disclosed is a dripping pills of six ingredients with Rehmanniae, which is prepared from dried rehmannia root, cornus officinalis, rhizoma dioscoreae, bark of peony root, Poria cocos, alisol as raw material as well as base material through the following steps, (1) distilling bark of peony root with water to extract volatile oil, (2) extracting cornus officinalis with 70% ethanol, concentrating to obtain concrete, (3) boiling rehmannia root, rhizoma dioscoreae with water, purifying with 70% ethanol, concentrating the alcohol liquid to obtain concrete, (4) steeping poria cocos to obtain extract, (5) merging the extract and spraying volatile oil, charging right amount of twain-80 to prepared plaster- solution, heating polyethylene glycol, charging in thick grease and volatile fluid, stirring homogeneously, instilling into fluid wax (0-5 deg. C), thus preparing drop pills.

The invention discloses a novel powder metallurgical gear. The novel powder metallurgical gear is prepared from iron powder, copper powder, molybdenum powder, vanadium powder, nickel powder, yttrium powder, aluminum powder, magnesium powder, cobalt powder, lead powder, steel slag powder, cupola slag powder, ferroalloy slag powder, modified tree ash powder, graphite powder, epoxidized butyl stearate, silicone oil, methylcellulose, aluminum stearate, polyethylene glycol, ethylene bisstearamide, stearic acid, carbon fibers, glass fibers, boron nitride, epoxy propoxy propyl trimethoxysilane, silica, manganese sulfide, acrylate, an inhibitor, a binder, an enhancer, a cutting agent, a lubricant, a coupling agent and a dispersion agent. According to the novel powder metallurgical gear, through the specific composition proportion, the novel powder metallurgical gear is even in overall density, high in density, high in ductility and area percentage reduction, good in wear resistance, strength and hardness, high in material utilization rate and suitable for quickly producing high-performance gears on a large scale.