2 results about "Lysosome" patented technology

The invention relates to the field of pharmaceutical preparation and the technical field of biological medicine, and particularly relates to a functional nano-carrier with a escape capability of lysosome and a preparation method of same. The functional nano-carrier is characterized in that the functional nano-carrier comprises arginine alkyl alcohol ester, medicament, carrier material and water. The functional nano-carrier has intense destructive effect on biological films in the condition of low pH value, so that the functional nano-carrier can rapidly destroy lysosome films in the conditionof acidic condition and rapidly escape into cytoplasm, is prevented from being destroyed by various enzymes and acid environment in lysosome, and is good for the exerting of the drug efficacy.

Novel leptin and leptin-fusion protein-small molecule drug conjugates are disclosed, where conjugation takes place through the use of cleavable and non-cleavable linkers. The small molecules chemically linked to the protein carrier are imported into the specific leptin-responsive target tissue or cell through receptor-mediated endocytosis and released from the carrier protein through enzymatic cleavage of the linker-drug moiety or through lysosomal degradation of the carrier protein. Free drug then act to modify leptin receptor-triggered biochemical pathways that are altered in conditions of leptin-resistance. Drug will correct altered pathway allowing resensitization of receptor signaling. This can greatly aid in the resolution of pathologies either initiated at the onset of leptin resistance or exacerbated by it.