86 results about "Active agent" patented technology

A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing molecule retains the ability to undergo free radical polymerization after attachment of the bioactive agent thereto. The first polymerizing molecule is preferably biocompatible. The polymerizing molecule can, for example. be dihydroxyphenyl-L-alanine (DOPA) or tyrosine. The composition can also include a second component synthesized by reacting at least one core molecule having a plurality of reactive hydrogen groups with at least one multi-isocyanate functional molecule to create a conjugate including terminal isocyanate groups. The conjugate molecule is reacted with a second polymerizing molecule that is adapted to undergo a free radical polymerization. The second polymerizing molecule includes a reactive hydrogen to react with the isocyanate groups of the conjugate. The second polymerizing molecule retains the ability to undergo the free radical polymerization after reaction with the conjugate. In several embodiments, the first polymerizing molecule and the second polymerizing molecule are the same and dihydroxyphenyl-L-alanine (DOPA) or tyrosine.

The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt, solvate, ester, and/or prodrug thereof, an ionic non-gelling matrix polymer, and a pH modifier. The ionic non-gelling matrix polymer is practically insoluble and unswellable at a first aqueous fluid pH and is soluble at a second aqueous fluid pH. The pH modifier is present in an amount to control the release of the active agent from the composition. The controlled-release composition is substantially free of a gelling or swellable excipient. The present invention also provides methods of making and using the controlled-release compositions.

This invention concerns compositions for the treatment of Lower Urinary Tract Symptoms (LUTS), and especially LUTS which results from benign prostatic hypertrophy. The compositions of the invention comprise a Beta-3 agonist described below, optionally in combination with a 5-alpha reductase inhibitor, or an NK-1 antagonist or an alpha-1 adrenergic antagonist or an anti-muscarinic agent. The invention also includes compositions comprising a beta-3 agonist and two additional active agents selected from a 5-alpha reductase inhibitor, an NK-1 antagonist, an alpha-1 adrenergic antagonist or an anti-muscarinic agent.

The invention relates to a composite underwater sound transmission rubber material and a preparation method thereof. A component A is prepared through steps of plasticating natural rubber, then adding into an internal mixer for mixing, adding metallic oxide, inorganic filler, active agent and accelerator for mixing, and discharging sheets by an open mill and testing; a component B is prepared through steps of plasticating chloroprene rubber, then adding into the internal mixer for mixing, then sequentially adding stearic acid, antiager, carbon black, inorganic filler and softener for mixing, adding sulphur for mixing, discharging sheets and cooling down; the composite underwater sound transmission rubber material is prepared through steps of mixing the component A and component B according to proportion of 1:1, packaging into triangle, thinning, discharging sheets, sampling for sulfuration test, and sulfurizing at relatively low temperature. The acoustic impedence of the material and acoustic characteristic impedence of water are well matched, the sound attenuation coefficient of sound wave transmitting in sizing material is low, the material has good hydrolytic resistance and silicone oil resistance; the material can be stored for long time, is safe to operate, has high underwater sound transmission performance, and can be sulfurized at low temperature so that the contradiction between low temperature sulfurization and normal temperature storage is relieved.

The invention relates to a method for preparing nano-scale alpha-type calcium sulfate hemihydrate whiskers in a reverse microemulsion system under normal pressure by using raw phosphogypsum as a raw material, and belongs to the technical field of preparation of inorganic functional materials. A fatty primary alcohol, a surfactant, and water are adopted to construct the reverse microemulsion reaction system, the raw phosphogypsum is added in a proportion, after uniform stirring, a PH regulator is added to control the PH value, and a crystal accelerator is added in a proportion; the reverse microemulsion reaction system is heated to a control temperature, and alpha-type calcium sulfate hemihydrate whiskers are formed by crystallization in nano-scale water droplets; and after filtering, washing and drying, the nano-scale alpha-type calcium sulfate hemihydrate whiskers having a high added value and having a diameter range of 200 nm to 500 nm are formed. The method has the advantages of simple process, high operability, short preparation time, low energy consumption, high yield, multiple times of use of the reverse microemulsion and washing water, high product added value, and the like,and is of great significance to ecological environment protection, natural gypsum resource saving, promotion of high value-added resource utilization of the phosphogypsum.

In part, the present invention is directed to compositions having a FabI inhibitor and at least one other bioactive agent. In another part, the present invention is directed to antibacterial compositions having a compound of formulas I-III and at least one other antibacterial agent.

Compositions are provided comprising a family of peptides having binding specificity for bone, and their use to produce coating compositions. The coating compositions are used to deliver a pharmaceutically active agent to bone, and are used in methods related to bone implants, bone repair, and bone-related diseases.

The invention provides a preparation method of a corrosion inhibitor of methanol gasoline, and belongs to the technical field of metal corrosion protection. The preparation method comprises steps as follows: alpha-methylstyrene dimer, maleic anhydride, dicumyl peroxide and dimethylbenzene are added into a reactor, and then, the mixture is heated in an atmosphere of nitrogen for reacting; after the mixture is cooled to the room temperature, octadecanol, polyethylene glycol, p-toluenesulfonic acid, n-butyl alcohol and ethyl acetate are added, the mixture is heated for reacting and then cooled to the room temperature, and a mixture I is obtained; the mixture I is washed with a sulfuric acid aqueous solution, then washed with an NaOH aqueous solution and finally washed with an aqueous solution, and a mixture II is obtained; and benzotriazole, 2, 6-tert-butyl-4-methyl phenol, hexamethylene tetramine, ethanol, propargyl alcohol, trimellitate, a surface active agent and a combustion improver are added into the mixture II and uniformly stirred, and the corrosion inhibitor is obtained. The provided methanol gasoline has good solubility with various oils, the additive amount is small, and the corrosion-resistant effect is superior to that of a similar product.

The invention relates to chlorine dioxide disinfection and smell elimination liquor, which includes chlorine dioxide aqueous solution of chlorine dioxide gas, and is characterized in that a pH regulator is also included to control pH value of the solution and ensure chlorine dioxide reaches a stable state; wherein, chlorine dioxide is dissolved in water in the shape of molecule. The chlorine dioxide disinfection and smell elimination liquor has the advantages that a pure chlorine dioxide disinfectant is provided which is dissolved in water in the shape of molecule; in use, no activator is needed to be added, realizing no need of activation indeed; owing to the dissolving of the dioxide disinfection gaseous molecule in water, effective maintaining concentration reaches over one year; applied concentration is low; security is good, without the danger of instability of ordinarily stable chlorine dioxide after activated and the generation of high concentration gas; the chlorine dioxide disinfection and smell elimination liquor can directly act on human skin; food level active agent is appended; demulsification and deoilness properties are added.

The invention belongs to the technical field of cosmetics, and discloses a cosmetic composition with high vitamin C content as well as a preparation method and application thereof. The cosmetic composition with high vitamin C content provided by the invention comprises the following components of vitamin C, a nonionic surfactant, an oil phase component, a water phase component, a water-soluble polymer and other active substances. The cosmetic composition provided by the invention has the characteristics of high vitamin C content, low water content, strong infiltration capacity, better stability, small irritation and the like, solves the product quality problems that common cosmetics are low in vitamin C content, cannot be stabilized at high concentration, even are easy to separate out andthe like, prolongs the shelf life of the product, and improves the application of the product.

The invention discloses a flux for SnAgCuNiGe alloy solder paste and a preparation method, comprising a polymerized rosin 25% to 30%, a hydrogenated rosin 8% to 16%, a rosin alcohol 6% to 12%, a modified and hydrogenated castor oil 2% to 3%, a hydrogenated castor oil wax 2% to 3%, an organic acid and halogen compound and other active agents 6% to 11%, a hydroquinone and other antioxidant 0.5% to 3%, a surface-active material 2% to 4%, and an organic solvent. The invention is characterized in that: the polymerized rosin, the hydrogenated rosin, the rosin alcohol, the organic solvent, the modified and hydrogenated castor oil, the hydrogenated castor oil wax, the active agent, and the antioxidant are utilized in turn and heated at temperatures of no more than 130 degrees Centigrade, then are sufficiently dissolved, evenly mixed and cooled to ambient temperature, finally the surface-active material is added to the mixture, and the cooling process is kept on for two to three hours, and the flux is obtained. The invention has an advantage of meeting demands of customers to the service life of the solder paste and requirements to the printing performance and welding property for the solder paste.

Disclosed for use in treating a metal, e.g., an alloy of silver as aforesaid, is a water-based composition comprising a treatment agent selected from an alkanethiol, alkyl thioglycollate, dialkyl sulfide or dialkyl disulfide and at least one of an amphoteric, nonionic or cationic surfactant in a concentration that is effective to solubilise the treatment agent. Preferably the composition comprises at least a non-ionic relatively hydrophobic surfactant e.g. cocamide DEA. The composition is particularly suitable for the treatment of Ag—Cu—Ge alloys.

The invention discloses a copper cleaning agent and a preparation method thereof, and belongs to the technical field of additives. The copper cleaning agent comprises the following raw materials in parts by weight, 15-20 parts of citric acid, 10-20 parts of sodium citrate, 5-10 parts of nonionic surfactant, 3-8 parts of penetrating agent, 3-8 parts of anionic surfactant, 2-3 parts of solubilizer,5-10 parts of antioxidant and 30-50 parts of water. The copper cleaning agent has the advantages of simple manufacturing process, easy operation, low price and easy availability of raw materials, no toxicity and harm, no harm to human bodies and no damage to base materials.

The invention relates to a high-activity multifunctional laundry bead and a preparation method thereof, and belongs to the technical field of daily chemical detergents. The laundry bead is prepared from dodecyl benzene sulfonate, dodecyl benzene sulfonic acid monoethanol amine salt, oleic acid monoethanol amide polyoxyethylene ether, fatty acid methyl ester ethoxylate, amine oxide, an organic silicon compound, deionized water, propylene glycol, an re-deposition resistant agent, triisopropanol amine, an anti-cross-color agent, a bacteriostatic agent, a compound enzyme, a water softener, a fluorescent whitening agent, a preservative, citric acid, essence and perfume. The raw materials are uniformly mixed and stirred, the pH is adjusted, then discharging is carried out, and finally packagingis performed to obtain the laundry bead. By adding a little amount of solvent and the dissolving property of a nonionic surfactant, the active matter content of the laundry bead can reach 80% and is 3-4 times higher than that of a traditional detergent in the market.

The invention discloses a camellia oleifera abel shell compound corrosion inhibitor and a preparation method and application thereof. The camellia oleifera abel shell compound corrosion inhibitor comprises 0.1-1.0 g/L of camellia oleifera abel shell extract, 0.05-0.5 g/L of aromatic aldehyde compound, 0.1-0.5 g/L of anionic surfactant, 0.01-0.1 g/L of polyvinylpyrrolidone and the balance picklingsolution. The preparation method comprises the following steps: mixing and uniformly stirring raw materials with the formula ratio to obtain the target camellia oleifera abel shell compound corrosioninhibitor. The camellia oleifera abel shell compound corrosion inhibitor is applied in acid pickling of iron and steel materials.

The invention relates to the technical field of cosmetics, in particular to a skincare cosmetic containing a self-repairing active agent and a preparation method of the skincare cosmetic. The skincare cosmetic containing the self-repairing active agent comprises substances as follows: a herba rhodiolae extract, a saffron extract, protease, cream, rice oil, palm oil, coconut oil and an emulsifier. The herba rhodiolae extract and the saffron extract are emulsified and homogenized with protease, the cream and the rice oil, the self-repairing active agent is obtained and matched with the palm oil, the coconut oil and propylene glycol esters of fatty acids and other substances, and the skincare cosmetic is obtained. The skincare cosmetic has the outstanding advantages as follows: the contained self-repairing active agent has effects of promoting blood circulation, activating collagen synthesis, keeping the skin in a good antioxidant environment and the like, the skin is enabled to be in an active state, skin immunity and regeneration physiological activity are improved, skin elasticity is improved, and the skin is enabled to have the lasting anti-aging characteristic.

The invention provides a preparation method of a high-strength tire curing bladder, and relates to the technical field of tire curing bladder production and processing. In a component of the tire curing bladder, raw rubber comprises butyl rubber and brominated butyl rubber; a filler comprises carbon black, acetylene carbon black, graphite and aluminum oxide; an active agent is zinc oxide master batch particles; a processing aid comprises stearic acid and paraffin; a vulcanizing agent comprises vulcanized resin and sulfur; wherein the unsaturation degree of the butyl rubber is 0.5-2%, and the brominated butyl rubber contains 1.5-2.5% of bromine. The preparation method comprises following steps: carrying out three-stage rubber mixing to process a rubber sheet, and then injecting and vulcanizing to obtain the tire curing bladder. Compared with the prior art, the invention has the advantages that the butyl rubber and the brominated butyl rubber are used as raw rubber, and an adopted rubberextruder is three-stage rubber mixing equipment, so that high-temperature mixing time is shortened, the stability of the brominated butyl rubber is maintained, the purpose of uniform mixing is achieved, and the vulcanization time can be shortened while the strength is improved.

The invention belongs to the technical field of acid bright copper plating additives and relates to a PEG coupled heterocyclic compound and application thereof in acid bright copper plating. The PEG coupled heterocyclic compound can be used as a leveling agent and a grain refiner, more importantly, can increase the solubility of a slightly soluble component in a brightener in a water phase, effectively avoid the precipitation of the slightly soluble component, meanwhile, improve the compatibility of the slightly soluble component with other components in the brightener, maintain the balance among the components, and avoid the problem of proportional imbalance caused by overlarge consumption speed difference or partial precipitation of the components; the PEG coupled heterocyclic compound,a polyether surfactant and a dithionate compound are pre-prepared into the brightener to be applied to acid copper plating; and through the synergistic effect of the three compounds, the stability ofan MN type brightener system is improved, and meanwhile, the current density range is widened on the basis that good leveling performance is ensured.