The present invention belongs to the field of ink, and in particular relates to highly wear-resistant PU ink for silicone rubber surface. The raw materials comprise hydroxyl-terminated polyurethane resin, curing agent, and mixed solvent. Moreover, the raw materials still comprise wear-resistant additives. The wear-resistant additives can be one of or the mixture of a plurality of polytetrafluoroethylene, polypropylene, polyethylene, polyethylene oxide, zinc oxide, alumina oxide, iron oxide, zirconium oxide, magnesium oxide, calcium carbonate, talc, silica aluminum, and magnesium silicate. With the proposal of the present invention, the suitable polyhydroxylated PU resin, curing agents and filler are used to prepare PU ink for silicone rubber of convenient construction, reduction of priming payer of middle coating, good adhesion and excellent wear resistance.