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69 results about "Solubility" patented technology

Solubility is the property of a solid, liquid or gaseous chemical substance called solute to dissolve in a solid, liquid or gaseous solvent. The solubility of a substance fundamentally depends on the physical and chemical properties of the solute and solvent as well as on temperature, pressure and presence of other chemicals (including changes to the pH) of the solution. The extent of the solubility of a substance in a specific solvent is measured as the saturation concentration, where adding more solute does not increase the concentration of the solution and begins to precipitate the excess amount of solute.

Crystal form G of ibrutinib and preparation method

The invention discloses a crystal form G of ibrutinib. The crystal form G is characterized in that X-ray powder diffraction (X-RPD) which adopts Cu-Kalpha radiation and is represented with a 2theta angle has diffraction peaks in positions at angles of 5.0 degrees plus or minus 0.2 degrees, 7.3 degrees plus or minus 0.2 degrees, 10.1 degrees plus or minus 0.2 degrees, 12.0 degrees plus or minus 0.2 degrees, 13.2 degrees plus or minus 0.2 degrees, 17.1 degrees plus or minus 0.2 degrees, 19.5 degrees plus or minus 0.2 degrees, 20.8 degrees plus or minus 0.2 degrees, 22.3 degrees plus or minus 0.2 degrees, 24.3 degrees plus or minus 0.2 degrees, 27.4 degrees plus or minus 0.2 degrees and 31.2 degrees plus or minus 0.2 degrees. Related solvents in a preparation process of the crystal form G are cheap, the conditions are mild, the operation is simple, good controllability and reproducibility are realized, further, the prepared crystal form has great stability, the HPLC (high performance liquid chromatography) purity is higher than 99%, and the phenomenon of crystal transformation can be avoided; besides, the solubility is high, the dissolubility is good, and the bioavailability is high.
Owner:孙霖

Preparation method of submicron CuS (copper sulphide) classification ball

InactiveCN102040239ARich in natureEasy to operateCopper sulfidesSolubilityElectrical conductor
The invention discloses a preparation method of submicron CuS (copper sulphide) classification balls. The method comprises the following steps: adding polymer into a good solvent to dissolve and remove big gel particles; adding copper source solution to the good solvent and stirring; adding sulfur source solution and then stirring; reacting the reaction liquid under 100-1,000 KPa at 100-200 DEG C; naturally cooling to the room temperature to obtain black precipitate; and washing and drying the precipitate to obtain the classification balls. The classification balls has the advantages of cheap and readily available templates, environmental friendliness, safety without toxicity, renewability and high water solubility, the contents of raw materials are abundant in nature and the operation of the reaction system is simple; the size and structure of the prepared classification ball are adjustable: the diameter can be controlled by adjusting the molar weight of the added precursor, the template concentration, the reaction temperature and time and the like; the operation is simple; and the prepared classification balls have wide application value in the fields of catalyst, catalyst carrier, optical equipment, sensor, lithium-ion rechargeable battery cathode material, superconductor and the like.
Owner:GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI +1

Hydrophilic UV (Ultraviolet) coating hardness assistant and preparation method thereof

ActiveCN103980760AHigh hardnessGood water solubilityCoatingsSolubilityPolyethylene glycol
The invention discloses a double-tail four-functional hydrophilic UV (Ultraviolet) coating hardness assistant and a preparation method thereof. The preparation method comprises the following steps: firstly, reacting polyethylene glycol monomethyl ether, isocyanate and one-generation hyperbranched polymer to form a prepolymer I, and subsequently reacting a prepolymer obtained after crylic acid monomer is reacted with isocyanate with the prepolymer I, thereby preparing the double-tail four-functional hydrophilic UV coating hardness assistant. According to the preparation method, high-functionality hyperbranched molecules are adopted as primary reaction materials, the characteristics that the hyperbranched molecules are high in functionality but low in viscosity are taken, when the prepared hardness assistant is added into an aqueous UV resin, not only is the problem that a coating is always low in curing property but high in viscosity solved, but also the water solubility of the UV resin is improved, the hardness of the aqueous UV resin is also improved, and the application range of the aqueous UV resin is widened. When non-ionic polyethylene glycol methyl ether is connected to molecules, therefore the acid-alkali resistance of the coating is improved, an emulsion system is well stabilized, and experiment shows that the effect is good.
Owner:INST OF CHEM MATERIAL CHINA ACADEMY OF ENG PHYSICS +1

Temperature sensitive paint for low-temperature use

InactiveUS20050040368A1High luminous intensityLarge variation in light emission intensityAnalysis using chemical indicatorsLuminescent paintsSolubilityLuminous intensity
The present invention provides a temperature sensitive paint for low-temperature use which shows durability at low temperatures, has a high light emission intensity, and makes it possible to perform precise temperature measurements of surface temperature fields by applying the paint to the surface of an object and measuring the light emission even in cases where the measurement distance is long in, for example, a large cryogenic wind tunnel or the like. The temperature sensitive paint for low-temperature use contains a ruthenium complex having a high light emission intensity as a temperature sensitive luminophore, a urethane type polymer as a binder, and an alcohol organic solvent as a solvent. Use of an alcohol organic solvent makes it possible to dissolve a temperature sensitive luminophore at a high solubility and to increase the light emission intensity by raising the temperature sensitive luminophore concentration in the coating film, so that more precise temperature measurements can be performed. By using the urethane type polymer having the durability at low-temperature, it is possible to obtain durability where no cracks occur at low temperatures even when the film thickness is increased. Therefore, adjustment of the light emission intensity and surface treatment such as surface polishing and the like can be performed by using this temperature sensitive paint for low-temperature use.
Owner:JAPAN AEROSPACE EXPLORATION AGENCY

Dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and preparation method thereof

ActiveCN109528690AIncrease surface areaHigh pore volumeOrganic active ingredientsPharmaceutical non-active ingredientsChemistrySolubility
The invention discloses dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and a preparation method thereof. The preparation method comprises the following steps of coating the rear surface physically adsorbing organic micromolecule medicines, of hollow mesoporous silicon nanometer microspheres, with polydopamine, then introducing disulfide bonds and aminos through an esterification reaction, performing surface acylation and bromination, performing grafting with poly(ethylene glycol) methyl ether methacrylate, and finally performing secondary physical adsorption of organic micromolecule medicines so as to obtain the hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methylether methacrylate medicine loading microspheres. According to the dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loadingmicrospheres disclosed by the invention, hollow mesoporous silicon can effectively perform medicine loading, the polydopamine coated hollow mesoporous silicon has unique pH and glutathione responsiveness, and the grafted polyethylene glycol can improve the biocompatibility and the water solubility of the nanometer microspheres. Under different lesion cell environment, medicines can effectively, synergistically and slowly release from mesoporous layers and polymer layers according to physiology environment changes, and the purpose of target treatment can be achieved.
Owner:SHAANXI NORMAL UNIV

Hexavalent chromium reducing agent and preparation method thereof

ActiveCN107915420APrevent oxidationHigh reactivitySolubilityOxygen
The invention provides a hexavalent chromium reducing agent and a preparation method thereof. The reducing agent contains the following components in parts by weight: 50-90 parts of an iron-based reducing agent, 0.57-3.6 parts of nanometer zero-valent iron and 0.9-7.1 parts of a dispersing agent. According to the hexavalent chromium reducing agent provided by the invention, an iron-based reducingagent is uniformly packaged by a dispersing agent solution containing nanometer zero-valent iron particles, and very high reaction activity is achieved by mixing nanometer zero-valent iron with the iron-based reducing agent, so that hexavalent chromium in the reducing agent solution can be rapidly reduced; dispersing agent molecules are capable of stabilizing nanometer zero-valent iron and packaging the iron-based reducing agent, so that the oxidation of the iron-based reducing agent by oxygen in the air is prevented, the hexavalent chromium reducing agent has a moisture preserving function, and the situations that because the partial water-entraining iron-based reducing agent is dehydrated under a high temperature condition, the solubleness is reduced, and the iron-based reducing agent isunlikely to participate in the reducing reaction of hexavalent chromium are prevented.
Owner:DONGYUAN HONGCHAO TECH

Device for preparing double-shell microcapsules

PendingCN108160014AEasy to manufactureEfficient manufacturingMicroballoon preparationMicrocapsule preparationSolubilityPeristaltic pump
A device for preparing double-shell microcapsules comprises a core material liquid inlet, a wall material liquid inlet, a vibrating system, a concentric nozzle, a collector, a stirrer, a peristaltic pump I, a second layer coating chamber, a rotatable screen, a coating liquid inlet, a peristaltic pump II, an atomizing nozzle, an air compressor, a temperature control system and the like. The deviceis simple; through control over the liquid inlet speeds of the core material liquid inlet and the wall material liquid inlet and the vibrating frequency of the vibrating system, the sizes of microcapsule cores are controlled, so that the microcapsules with uniform sizes are prepared and damage during microcapsule preparation is reduced; through hardening liquid filtration and hot air fluidization,rapid moulding of first-layer microcapsules is achieved; through control over the atomizing pressure and the coating liquid solubility, the shell thickness of second-layer coating is controlled. A preparation technology is simple, the reaction condition is mild, the control is easy, and the repeatability is relatively good; in addition, because of a sealing property of the device, influence of the environment on the microcapsules is greatly reduced, so that the double-shell microcapsules can be effectively prepared and the preparation time is greatly shortened.
Owner:NANCHANG UNIV

Anti-aging folia perillae acutae oil nano-emulsion cosmetic

InactiveCN102166175AImprove solubilityImproves free radical scavengingCosmetic preparationsToilet preparationsSolubilitySkin permeability
The invention discloses an anti-aging folia perillae acutae oil nano-emulsion cosmetic. The grain diameter of the cosmetic is 6-100nm. The anti-aging cosmetic comprises the following raw materials: 15.00-31.00wt% of surfactant, 4.00-7.00wt% of oil, 0.10-10.00wt% of folia perillae acutae oil, 1.00-2.00wt% of vitamin E acetic ester, 0.10-0.20wt% of essence and the balance of distilled water, wherein the total amount is equal to 100%. The cosmetic has better skin permeability, can enhance the solubility of the folia perillae acutae oil, improves the anti-aging effect of the folia perillae acutae oil, improves the ductility of the cosmetic on the skin, and brings clear and moisture good feeling for users. The anti-aging cosmetic has wide market prospect in the field of the anti-aging cosmetics.
Owner:杨平

Method for separating and purifying crude lanosterol product

InactiveCN101691391AMake up for the disadvantage of low solubilityIncrease productionSteroidsSolubilityLanosterol
The invention discloses a method for separating and purifying a crude lanosterol product in the technical field of the purification of organic substances, which comprises the steps of: dissolving the crude lanosterol product into an organic solvent at a temperature of between 25 and 40 DEG C through ultrasonic treatment to obtain a lanosterol solution; and filtering the lanosterol solution by a filter membrane, then using preparative high performance liquid chromatography to adopt overlapping injection for separation and purification treatment to obtain purified lanosterol. The method adopts reversed-phase high performance liquid chromatography, can ensure the characteristics of good resolution, high yield, high recovery rate, good purity and the like, can directly separate to obtain the lanosterol with the purity over 97 percent, and can be used for various sterol-related diseases and the research and development of biosynthetic pathways of various natural products. The method applies technology such as overlapping injection and linear amplification to overcome the disadvantage of low solubility caused by using reversed-phase chromatography to separate the lanosterol, uses a preparation column with the inner diameter of 20mm and the column length of 250mm, ensures that the daily preparation amount can reach near 250mg, and can meet various scientific and research requirements.
Owner:SHANGHAI JIAOTONG UNIV

Organic corrosion inhibitor for inhibiting magnesium alloy corrosion and application method of organic corrosion inhibitor in automobile cooling liquid or corrosion aqueous solution

ActiveCN103590045AReduce dosageHigh corrosion inhibition efficiencySolubilityPyrazine
The invention discloses an organic corrosion inhibitor for inhibiting magnesium alloy corrosion and an application method of the organic corrosion inhibitor in an automobile cooling liquid or a corrosion aqueous solution. The corrosion inhibitor consists of the components in percentage by weight: 10-90 percent of pyrazine or/and piperazine and 10-90 percent of water or/and ethanol. According to the application method, the corrosion inhibitor is added into the automobile cooling liquid or the corrosion aqueous solution which immerses a magnesium alloy according to an adding amount of 50-1,000 ppm under a condition at the temperature of -50-90 DEG C. The using amount of the corrosion inhibitor disclosed by the invention is small; the corrosion inhibitor is high in corrosion inhibition efficiency and good in corrosion inhibition effect; under normal temperature, the corrosion inhibition rate can be over 90 percent. The corrosion inhibitor is organic, so that the common shortcomings of an inorganic corrosion inhibitor are overcome; the application temperature range is wide; the organic corrosion inhibitor is applicable to low temperature and normal temperature and can still effectively inhibit corrosion of the magnesium alloy in a solution medium with higher temperature, and the corrosion inhibition rate can be over 80 percent under the higher temperature. The corrosion inhibitor product disclosed by the invention has the advantages of simplicity in production, wide application range, no toxicity, no peculiar smell, complete water solubility, safety and convenience in operation, good economical property and the like.
Owner:武汉钢铁有限公司
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