30results about "Antimycotics" patented technology

Epimers and isomers of tetrazole-containing rapamycin analogs and a pharmaceutically acceptable salt or prodrug thereof, are immunomodulatory agents and are useful in the treatment of restenosis and immune and autoimmune diseases. Also disclosed are cancer-, fungal growth-, restenosis-, post-transplant tissue rejection- and immune- and autoimmune disease-inhibiting compositions and a method of inhibiting cancer, fungal growth, restenosis, post-transplant tissue rejection, and immune and autoimmune disease in a mammal. One particular preferred application of such isomers and epimers of tetrazole containing rapamycin and 42-Epi rapamycin analogs is in medicated devices and local vascular delivery wherein the stability and lipid solubility and subsequently diffusion through tissue and cell membranes are essential to the success of rapamycin containing combination devices.

The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include non-temperature dependent phase change compositions that may be formulated as solutions, solids, semisolids, microparticles, or crystals.

A method of preparation of a treated Spirulina compound includes the steps of rehydrating desiccated Spirulina, stressing the culture and freeze drying to a powder. The resultant compound has activity as an anti-viral compound and an anti-bacterial compound. It is capable of effecting repair of skin defects in mammals and acting as a preventative agent to skin defects.

The invention discloses a preparation method of high-purity gynostemma pentaphylla total saponin for veterinary drugs. The preparation method is characterized in that a medicinal gynostemma pentaphylla total saponin medicinal material is used as a raw material, and the high-purity target product, namely the gynostemma pentaphylla total saponin for the veterinary drug, is obtained by high-efficiency extraction and separation on the basis of combination of technologies such as continuous countercurrent supersonic wave extraction, ceramic membrane microfiltration and macroporous resin adsorption separation with a conventional solvent reflux extraction principle. The preparation method has the advantages that the product purity and the product yield are improved, the product quality and the high quality are stabilized, the production cost is reduced, the requirements on the development of the high-purity gynostemma pentaphylla total saponin for the veterinary drugs and highly-processed products of gynostemma pentaphylla total saponin are satisfied, the production process is in line with environmental protection requirements, and the difficulty in the coordination of working procedures such as extraction, solvent recovery, enrichment and purification occurring in the volume production process of the gynostemma pentaphylla total saponin for the veterinary drugs is solved through the continuous improvement of the technology and the adjustment of technological processes and technical parameters.

The invention discloses an antibacterial whitening mouthwash and a preparation method thereof. The antibacterial whitening mouthwash comprises an antibacterial component and a mouthwash matrix component, wherein the antibacterial component comprises 0.05 to 0.5 part of lysozyme, 0.01 to 0.5 part of lauryl arginine ethyl ester hydrochloride, 0.01 to 1 part of dextran anhydrase and 1 to 10 parts ofabelmoschus manihot extract. A substrate component of the mouthwash comprises one or more of an emulsifier, a moisturize, a flavoring, an acid-base conditioner and an essence, and the balance is deionized water. Lysozyme and lauryl arginine ethyl ester hydrochloride are dissolved in a citric acid solution and uniformly stirred; the prepared ingredients are mixed with the emulsifier, moisturizer, flavoring and essence evenly, pH is adjusted, and abelmoschus manihot extract and dextran enzyme are added. The invention makes the synergistic effect between the natural antibacterial agent and the chemical antibacterial agent exist, and the mouthwash produced by the invention has high safety and good antibacterial activity, and can effectively prevent and control the occurrence of dental plaque and oral inflammation.

The invention relates to a pharmaceutical composition for treating beriberi. The weight ratio of the active ingredient lysozyme to the active ingredient osthole is (1:10)-(10:1). Compared with ordinary western medicine preparations, the lysozyme preparation has the advantages that the preparing method is simple, compatibility of medicines is high, and the two active ingredients have their own functions and can also generate synergistic interaction so as to treat beriberi remarkably. Lysozyme and osthole both have natural sources and are safe, free of toxin and free of side effect. Due to the fact that no western medicine antibacterial agent is contained in the pharmaceutical composition, the pharmaceutical composition has no drug resistance.

The invention belongs to the field of daily chemical products, particularly relates to bacteriostatic foot powder and a preparation method thereof, and provides bacteriostatic foot powder. The bacteriostatic foot powder comprises the following components in percentages by weight: alkannin 1-3%, cinnaldehydrum 2-4%, berberine 1-5%, patchouli alcohol 2-4%, menthol 1-2%, alkyl glycoside 2-6%, tea saponin 0.5-1.5%, dipotassium glycyrrhizinate 1-3%, a deodorant 2-10%, ethanol 5-25% and corn flour 36.5-82.5%. The bacteriostatic foot powder not only can effectively improve foot hyperhidrosis and prevent and treat foot odour, but also can inhibit bacteria, diminish inflammation and resist allergy, and effectively treats tinea pedis. Meanwhile, the provided bacteriostatic foot powder is gentle in property, and is safe and non-irritant.

The invention relates to the field of immunology and specifically relates to a method for amplifying and activating natural killer (NK) cells to become lymphokine activated killer (LAK) cells through the action of a CD 8 alpha-interleukin 21 fragment-CD137 complex. The method disclosed by the invention has the advantages that compared with existing similar complexes, the capability of amplifying and activating the lymphocyte cells is stronger and the efficiency is higher through the CD 8 alpha-interleukin 21 fragment-CD137 complex. The method disclosed by the invention has broad prospects in the aspect of immunotherapy.

The present invention discloses diamondback moth cecropin 3, a preparation method and an application thereof, wherein the diamondback moth cecropin 3 gene has a nucleotide sequence represented by SEQIDNO:1-2 and has a corresponding amino acid sequence represented by SEQIDNO:3, and sequence analysis results show that the mature peptide of the diamondback moth cecropin 3 has an amino acid sequence represented by SEQIDNO:4. According to the present invention, the diamondback moth cecropin 3 gene or the mature peptide sequence thereof is subjected to prokaryotic expression to obtain the diamondback moth cecropin 3, and the obtained diamondback moth cecropin 3 provides strong inhibition effects for gram-negative bacteria and gram-positive bacteria, provides strong inhibition effects for pathogenic fungi, especially provides strong inhibition effects for a lot of pathogenic fungi of melons and fruits, and is expected to be a novel peptide antibiotic.

The invention belongs to the field of medicines, and particularly relates to a pharmaceutical composition for treating invasive infection of candida albicans echinocandin drug-resistant bacteria and an application of the pharmaceutical composition. The active components of the pharmaceutical composition are composed of caspofungin and a compound L-269289, and in a strain for inhibiting drug resistance of candida albicans echinocandin in vitro, the mass ratio of caspofungin to the compound L-269289 is 1: 3-1: 36; and for treating invasive infection of a candida albicans echinocandin drug-resistant strain on mice, and the mass ratio of caspofungin to the compound L-269289 is 1: 10. In-vitro experiments prove that the combined use of caspofungin and the compound L-269289 can effectively killthe candida albicans echinocandin drug-resistant bacteria, and is suitable for treating invasive infection of the candida albicans echinocandin drug-resistant bacteria on mice.

The invention discloses a compound clobetasol propionate nano-medicament of which the particle size is 1-100 nanometers. The medicament consists of the following components in percentage by weight: 10.0-50 percent of surfactant, 0-8 percent of cosurfactant, 0.5-20 percent of oil, 0.001-4.0 percent of amitraz, 0.001-4.0 percent of clobetasol propionate, 0.001-10 percent of terbinafine and the balance of distilled water, wherein the total percentage by weight of the components is 100 percent. The medicament has the effects of resisting bacteria, diminishing inflammation, relieving itching and pain, killing mites and treating fungal diseases, eczema and various types of dermatitis caused by fungi such as dermatophyte, microsporosis capitis, acrothesium floccosum, microzyme of monilia and chaff ringworm fungus, and the like. The medicament is a yellow or colorless clear transparent liquid and has the advantages of high stability, high wetting property, good transdermal effect, nontoxicity, non-irritation, high safety, easiness for preparing, low cost and convenience for popularizing.

The invention belongs to the field of healthy products, and relates to a probiotic composition special for female and application thereof. The probiotic composition special for female is characterizedby comprising 3%-20% of a female probiotic milk, 5%-50% of a stabilizer and 30%-80% of an adsorbent. In the probiotic composition special for female, other pharmaceutically acceptable auxiliary materials are selectively added, comprising a filler, an excipient, a lubricant, a gel, a binding agent, a flow aid, a disintegrating agent and a propellant. The probiotic composition special for female can be prepared into dosage forms such as powders, capsules, pills, tablets, sprays, ointments and gels and has effects of restoring vagina beneficial bacterium flora, reducing pH value in vagina and inhibiting growth of pathogenic bacteria. The preparation process of the probiotic composition special for female is simple and practicable, the used components are all common and moderate price. The probiotic composition special for female has good industrial prospect. The invention also provides the preparation process of the probiotic composition special for female.

The invention discloses traditional Chinese medicine bath antibacterial liquid/granules for regulating the Yang-deficiency constitution and a preparation and using method. The traditional Chinese medicine bath antibacterial liquid/granules are prepared from, by weight, 5-35 parts of rhizoma cibotii, 5-35 parts of fructus litseae, 5-35 parts of fructus cnidii, 5-35 parts of cassia twig, 5-35 partsof perilla leaves and 5-50 parts of tremella fuciformis. The preparation method comprises the steps that the tremella fuciformis is smashed into superfine tremella fuciformis powder; the other medicine materials are mixed and decocted by adding water, and then filter liquor is collected; the superfine tremella fuciformis powder is added into the filter liquor to obtain a mixture, the mixture is decocted and then concentrated into thick liquid with the relative density of 1.05-1.25, and the thick liquid is filtered to obtain the traditional Chinese medicine bath antibacterial liquid; the traditional Chinese medicine bath antibacterial liquid is further prepared to obtain the antibacterial granules. The traditional Chinese medicine bath antibacterial liquid/granules can effectively regulatethe Yang-deficiency constitution, and therefore, the aims of building the body and preventing diseases are achieved.

The invention discloses a microbial preparation for treating vaginitis. The microbial preparation is prepared from the following components in parts by mass of 50-90 parts of water, 8-12 parts of molasses, 10-25 parts of saccharomycetes, 18-27 parts of bacillus, 45-55 parts of lactic acid bacteria, 5-10 parts of photosynthetic bacteria and 15-25 parts of bifidobacterium. The preparation method comprises the steps of 1, taking a certain amount of water, uniformly stirring the water and the molasses, heating to 121 DEG C, maintaining the pressure and preserving the heat for 30 minutes; 2, reducing the temperature to 35 DEG C; 3, adding a certain amount of saccharomycetes, bacillus, lactic acid bacteria, photosynthetic bacteria and bifidobacteria into the solution stirred in the step 2; and 4, enabling the microbial preparation prepared in the step 3 to be subpackaged and stored at the normal temperature. The preparation method is simple, low in cost, simple in storage method, good in vaginitis treatment effect, safe in clinical application, free of adverse reactions and convenient to popularize widely.

The invention discloses foot bath liquid for preventing and treating callosities. The foot bath liquid is prepared from the following raw materials in parts by weight: 30-50 parts of seaweed, 20-40 parts of common selfheal fruit-spike, 10-30 parts of curcuma zedoary, 10-30 parts of argy wormwood leaf, 8-20 parts of safflower, 3-8 parts of pricklyash peel and 20-45 parts of vinegar. The foot bath liquid provided by the invention is safe and stable, is convenient and comfortable to use, has significant effects of preventing, treating and eliminating callosities, sterilizing and inhibiting bacteria, has a good moisture retention effect on skin at the same time, and can be used for daily health protection to prevent the callosities from causing other complications such as ulcers, beriberi and the like.

The invention discloses a preparation for treating beriberi. The preparation comprises the following raw materials by weight: 1 to 3 g of borneol, 2 to 5 g of kusnezoff monkshood root, 3 to 5 g of alum and 1 to 2 g of realgar. The preparation further comprises salvianolic acid effective parts, and the content of the salvianolic acid effective parts in the whole preparation is 1% to 75%. According to the invention, a certain percentage of the salvianolic acid effective parts are added into commonly used drugs, so the purpose of thorough treatment of beriberi can be achieved, a good effect is obtained, and beriberi does not recur.

Subject-matter of the invention is a process for preparing intermediates useful in the synthesis of drugs, for example antifungal drugs, such as efinaconazole. Subject-matter of the invention are also such novel synthesis intermediates and the use thereof.

The invention relates to a composite antibody extract, a preparation method and applications thereof. The preparation process of the composite antibody extract comprises: preparing a composite antigencontaining facial pathogenic bacteria, carrying out strengthening immunization on chicken, obtaining immunized eggs, separating and purifying the egg yolks of the immunized eggs to obtain a crude extract, and continuously separating and purifying to obtain an extract containing a composite antibody against the facial pathogenic bacteria. According to the present invention, the prepared compositeantibody extract has characteristics of high stability, strong antibody specificity and good safety, and can effectively resist the infestation of facial pathogenic bacteria, effectively resist bacteria and remove acne, and reduce the recurrence of acne.

The invention provides a method of killing an infectious microbe by administering an effective amount of transferrin to an individual having a microbial infection, wherein the transferrin has microbicidal activity, thereby reducing survival of the infectious microbe in the individual. The invention also provides a method of prophylactically treating an individual to decrease the likelihood of contracting a microbial infection, comprising administering an effective amount of transferrin to an individual, wherein the transferrin has microbicidal activity, thereby decreasing the likelihood that the individual will contract a microbial infection. The invention still further provides a method of treating septicemia by administering an effective amount of transferrin to an individual in need thereof, thereby treating the individual.

The invention discloses a traditional Chinese medicine composition for treating skin diseases and venereal diseases. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: centella asiatica, glossy privet fruits, purslane, smoked plums, semen momordicae, flos hibisci, radix isatidis, radix sophorae flavescentis, cortex meliae, herba epimedii, olive leaves, herba chloranthi serrati, saponin, cortex dictamni, stenoloma chusana, fructus kochiae, zinc oxide, tripterygium wilfordii, lalang grass rhizomes, artemisia anomala, sulfur, coptis chinensis, asarum, catechu, calamine, persimmon leaves, blister beetles, minium, cod-liver oil, rhizoma smilacis glabrae and radix cynanchi paniculati. The traditional Chinese medicine composition is prepared from pure traditional Chinese medicines, has no irritation to skin, causes no pain to patients, is low in treatment cost and unique in effect, is rich in skin nutritional agents and penetrants in preparation, is prepared from all-around traditional Chinese medicinal materials, and lays a solid foundation for treating skin venereal diseases.

The invention relates to a T cell capable of improving immune response, and a preparation method and application thereof. The T cell capable of improving the immune response is prepared by integratingan exogenous gene 4-1BBL onto chromosomes of an antigen-specific T cell for overexpression. The T cell capable of improving the immune response has the advantages of fast proliferation, high expression quantity of IFN-gamma, is especially capable of remarkably promoting the proliferation and IFN-gamma expression levels of antigen-specific T cells surrounding the T cell capable of improving the immune response and carrying no exogenous gene, functions as a general in the aspect of activating the immune response capability of the surrounding antigen-specific T cells, and plays a critical role in treatment of tumors, chronic virus infections and bacterial infections.

The invention discloses an application of nerol in the preparation of a drug or pharmaceutical composition for preventing and treating oropharyngeal candidiasis, and belongs to the field of biologicalmedicine. The drug is a medicament prepared by using nerol as an active ingredient and adding a pharmaceutically acceptable auxiliary material. The real-time fluorescence quantification, ultravioletspectrum scanning and other technologies are used to find that nerol has relatively strong anti-Candida albicans effects at a relatively low dose of 1.54 [mu]L/mL. A mouse immunosuppression model is used to perform in vivo experiments, the prevention and treatment effect of nerol on oropharyngeal candidiasis is evaluated, fungal tests and histopathological examinations prove that nerol has relatively strong treatment effects on oropharyngeal candidiasis, and can be used for the preparation of the drug or pharmaceutical composition for preventing and treating oropharyngeal candidiasis.

The invention relates to the field of traditional Chinese medicine preparations, and relates to a herbal itching relieving bag which is characterized by being mainly prepared from senecio scandens, mint, radix sophorae flavescentis, purslane, motherwort, scouring rush, honeysuckle, dandelion, polygonum cuspidatum, radix stemonae, houttuynia cordata, fructus kochiae, cocklebur fruit, fructus cnidii, wild chrysanthemum and Chinese mugwort. The weight ratio of the raw materials is as follows: 5-25 g of senecio scandens, 3-20 g of mint, 3-20 g of radix sophorae flavescentis, 3-20 g of purslane, 3-20 g of motherwort, 3-20 g of scouring rush, 3-20 g of honeysuckle, 3-20 g of dandelion, 3-20 g of polygonum cuspidatum, 1-9 g of radix stemonae, 1-9 g of houttuynia cordata, 1-9 g of fructus kochiae, 0.5-6 g of cocklebur fruit, 0.5-6 g of fructus cnidii, 0.5-6 g of wild chrysanthemum and 0.5-6 g of Chinese mugwort the itching relieving bag has the characteristic of good healing effect.