Compositions for sustrained release of nitric oxide, methods of preparing same and uses thereof
a technology of nitric oxide and composition, which is applied in the field of compositions for supressed release of nitric oxide, methods of preparing same, and uses thereof, can solve the problems of increasing antibiotic resistance, biofilm further impedes the activity of host defenses and standard antibiotic therapy, and the effectiveness of conventional wound infection treatment is not improving
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[0021]The present invention provides compositions for releasing nitric oxide (NO) comprising a matrix that encapsulates nitric oxide. Nitric oxide is released when the composition is exposed to an aqueous environment. As used herein, aqueous environments include moist environments, including for example, the surface of the skin.
[0022]A preferred composition for releasing nitric oxide (NO) comprises nitric oxide encapsulated in a matrix of chitosan, polyethylene glycol (PEG), and tetra-methoxy-ortho-silicate (TMOS). Another preferred composition for releasing nitric oxide (NO) comprises nitric oxide encapsulated in a matrix of trehalose, and non-reducing sugar or starch. The composition can further comprises nitrite, reducing sugar, and / or chitosan. Nitric oxide is released when the composition is exposed to an aqueous environment. For example, one preferred composition for releasing nitric oxide (NO) comprises nitrite; reducing sugar; chitosan; polyethylene glycol (PEG); tetra-metho...
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