215 results about "Disease" patented technology

The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

The invention relates to a method for producing an amino acid tobacco-specific foliar fertilizer by using abandoned fur. The method comprises the following steps of: degreasing, drying and crushing various abandoned animal hair in slaughterhouses, hair in barber shops and various abandoned animal leather which are used as main raw materials; carrying out microbial fermentation, mainly Freund crack mould or other keratin decomposing bacteria fermentation; then decomposing and filtering to prepare a crude amino acid solution; and chelating the following components in parts by weight: 30-50 parts of crude amino acid solution, 15-18 parts of potassium sulfate, 15-25 parts of ammonium sulfate, 15-18 parts of potassium dihydrogen phosphate, 3-6 parts of humic acid potassium, 1.3-2 parts of trace elements, 0.3-0.5 part of surfactant, 0.5-1 part of chelating agent and 0.15-0.2 part of plant growth regulating agent. The tobacco-specific foliar fertilizer has the effects of promoting growth of tobacco roots, enhancing the absorption and utilization of tobacco on soil and the fertilizer, promoting lengthening, widening and thickening of tobacco, enhancing the ability of disease resistance, and improving the quality and yield of tobacco leaves.

The present invention relates to oligo double-stranded RNAs for use in knockdown of the expression of Bcl-2 protein known as a suppressor for apoptosis, and pharmaceutical compositions containing them. It is known that Bcl-2 protein is over-expressed in diseases such as cancer, and by this over-expression, the growth of cancer cells is continued and the drug resistance to anti-cancer agents is caused. The present invention provides highly active oligo double-stranded RNAs cleaving bcl-2 mRNA and further provides pharmaceutical compositions comprising a complex of the oligo double-stranded RNA and a suitable carrier for inhibiting the expression of Bcl-2 protein.

In agriculture when temperature and moisture deviate from the norm two things happen, plant growth suffers and disease flourishes. The Stoller model for plant growth states that proper hormone balance is necessary for optimum growth and performance. When growth conditions deviate from the norm, hormone balance is altered and plant growth suffers. This invention presents evidence to support this model and explain the relationship between hormone levels and plant growth. A clear understanding of this relationship will facilitate crop treatments aimed to eliminate these problems. Although we cannot control the climate, we can control the damage caused by environmental stresses by manipulating the levels and/or ratio of plant hormones in the different plant tissues. By adjusting the levels and/or ratios of hormones, particularly auxin and cytokinins in the root tissue, we can assist the plant in overcoming or compensating for this environmental stress.

The invention provides novel indazole-carboxamide 5-HT₄ receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT₄ receptor activity, and processes and intermediates useful for preparing such compounds.

The invention discloses a method for ecologically cultivating freshwater shrimps in a paddy. The method includes the following steps that the paddy is fertilized and then raked, a communicated cultivating ditch is excavated in the raked paddy, a field ridge is built around the cultivating ditch with excavated soil, the height of the field ridge ranges from 45 cm to 70 cm, and the width of the field ridge ranges from 60 cm to 90 cm; the cultivating ditch is provided with a water inlet and a drainage opening, the water inlet and the drainage opening are respectively provided with a device preventing the freshwater shrimps from escaping, a pond occupying 5%-8% of the area of the whole paddy is excavated on the water inlet, and the depth of the pond ranges from 80 cm to 110 cm; the paddy is sterilized through calcium oxide; seedlings of a rice variety are inserted into the sterilized paddy, wherein the stalks of the seedlings are thick and strong, the seedlings are resistant to lodging, diseases and fertility and grow in deep water, and the yield is high; the freshwater shrimps are fed after the seedlings turn green; bait is thrown during cultivating according to the freshwater shrimps in different growth stages, and meanwhile water keeps clean. The freshwater shrimps cultivated in the method are natural and free of pollution and are pure green food.

The present invention provides methods, compositions, and kits for the treatment of disorders associated with overactivation of FGFR3, such as achondroplasia; bone or cartilage disorders; or vascular smooth muscle disorders, or for the elongation of bone. In some embodiments, the present invention provides polypeptides having a natriuretic peptide fused to an Fc domain of an immunoglobulin. Such polypeptides can be administered to subjects, e.g., subcutaneously, to treat a disorder associated with overactivation of FGFR3, a bone or cartilage disorder, or a vascular smooth muscle disorder, or to elongate bone. The invention also features nucleic acid molecules encoding such polypeptides and the use of the nucleic acid molecules for treating disorders associated with overactivation of FGFR3, bone or cartilage disorders, or vascular smooth muscle disorders, or for elongating bone.

The present invention relates to a biological control strain AR156 for preventing and treating root-knot nematodes of greenhouse vegetable, belonging to plant protection technical field. The bacteria is bacillus sp., which is cultivated in PDA culturing liquor under 37 degree and 180rpm, then is centrifuged 10min under 6000rpm. Picking wet bacteria and bacteria storage liquid is prepared into bacteria agent according to 1:40 (g/ml)proportion. The living bacteria concentration is 1*109-1*1012cfu/ml.The effective rate of the bacteria agent amount to 58-75% for preventing root-knot nematodes of cucumber, towel gourd, tomato etc, and yield increase more than 30-50%. The bacteria agent can also treat wilt, epidemic disease and soil hardening. The bacteria agent can be sprayed, composted and irrigated to root.

The invention relates to the field of livestock breeding and particularly relates to an anti-stress synbiotics traditional Chinese medicine composition for chicken. The anti-stress synbiotics traditional Chinese medicine composition consists of a micro-ecological synbiotics feed additive and a Chinese herbal medicine additive, wherein the micro-ecological synbiotics feed additive consists of the following components in parts by weight: 10-60 parts of micro-ecological probiotics and 40-90 parts of oligosaccharide, 20-45 billion living bifidobacteria are contained in per gram of micro-ecological synbiotics feed additive, the micro-ecological probiotics are a bifidobacteria preparation, the oligosaccharide is any one or more of fructooligosaccharide, xylooligosaccharide, isomaltooligosacharide and soybean oligosaccharides, the micro-ecological synbiotics feed additive accounts for 1-2% of the total weight of the anti-stress synbiotics traditional Chinese medicine composition for chicken, and the Chinese herbal medicine additive consists of the following components in parts by weight: 3-5 parts of schisandra, 10-15 parts of keels, 15-18 parts of zizyphus jujube kernel, 10-20 parts of nymphaea tetragona and 25-30 parts of clover. The anti-stress synbiotics traditional Chinese medicine composition can be used for improving the immunity and anti-stress capability of the chicken, and reducing the incidence of diseases.

A method for diagnosing water-core disease of fruit based on character band of visible near-infrared spectrum includes shining light on surface of fruit, using a numbers of photosensitive transducers to collect spectrum reflectivity information of fruit internal at various character bands, removing off noise of said information, inputting information to monolithic computer through A/D converter, inputting processed information to spectrum model of water-core disease for obtaining diagnosis result of water-core disease and using display to indicate out diagnosis result.

The invention relates to a drug use warning information processing method. The method is characterized by comprising the steps of 1, receiving drug use medical order information generated by a first terminal; 2, extracting drug use information and disease condition information from the drug use medical order information; 3, querying a reasonable drug use rule library by utilizing the drug use information and the disease condition information, and when the drug use information does not conform to the reasonable drug use rule library, executing the step 4; and 4, generating a drug use unreasonable rule data set according to the reasonable drug use rule library, wherein the drug use unreasonable rule data set contains a drug use unreasonableness value; and 5, generating drug use warning information, wherein the drug use unreasonableness value is marked in the drug use warning information. According to the drug use warning information processing method provided by the invention, the unreasonable drug use situation can be avoided, so that the drug use safety of patients is improved.

The invention discloses an external-use medicine for treating neck, shoulder, waist and leg diseases and osteoproliferation, and a preparation method of the medicine. The external-use medicine comprises active ingredients in parts by weight as shown in the description. The preparation method of the external-use medicine comprises the steps of wine soaking, drying, crushing, stirring, packaging and the like. The external-use medicine is completely prepared from traditional Chinese medicines and has the effects of warming channel, activating blood circulation, expelling wind, removing dampness, relieving swelling and pain, invigorating qi and blood, promoting blood circulation to remove blood stasis, tonifying kidney and strengthening du meridian. The external-use medicine has the advantages of good treatment effect, fast curative effect, very low toxicity, convenience in use and no limitation for treatment of the neck, shoulder, waist and leg diseases and the osteoproliferation. The preparation method is simple. The external-use medicine can be prepared into medicine packages which can be applied to home health care and medical treatment and are easy to carry.

Described herein are substituted 2-(azetidin-2-on-1-yl)alkanoic acids, alkanedioic acids and 2-hydroxyalkyl alkanoic acids, and 2-acyl alkanoic acids, and derivatives thereof, that are capable of modulating activity at the cannabinoid-1 (CB1) and/or cannabinoid-2 (CB2) receptor. Also described herein are methods for treating mammals in need of relief from disease states associated with and responsive to modulation of the CB1 and/or CB2 receptor activity.

The invention discloses a midnight-noon ebb-flow low frequency symptom. The midnight-noon ebb-flow low frequency symptom and sign differentiation therapeutic apparatus comprises a display terminal module, a control module and an output module. The invention is characterized in that an acupuncture point data database and a disease data database are stored in a storing device in the control module, a computer model is established between the two databases through time acupuncture rules of midnight-noon ebb-flow and eight methods of intelligent turtle, a user is clued to find out a therapeutic program corresponding to symptom through a software interface, and when or how to treat or keep health is clued according to the choice of the user. The invention can essentially provide an intelligent acupuncture system of treatment planning and best treatment time for the users.

The invention discloses a double-layer dragon fruit planting method. Rectangular pieces are made firstly, the line spacing is 2.8-3.2 m, the width of the rectangular pieces is 1.4-1.8 m, and the height of the rectangular pieces is 20-30 cm. Cement columns with the radius of 5-7 cm are uniformly arranged on the rectangular pieces at intervals of 2-3 m, wherein the height is 175-185 cm. Two layers of rectangular frames are arranged on the columns, the lower-layer height is 95-105 cm, the upper-layer height is 170-180 cm, and the upper layer of rectangular frames is 3-5 cm away from the top ends of the columns. The width of the rectangular frames is 26-35 cm. Bamboo poles are arranged among the columns, long and short bamboo poles are arranged at intervals, long bamboo poles are connected with upper-layer long rods, short bamboo poles are connected with lower-layer long rods, and the separation distance of the bamboo poles is 40-50 cm. During planting, seedling selection, leveling, fertilization and separated planting, water and fertilizer management, branch pruning, flower and fruit management and dragon fruit planting management of disease and pest prevention and control are performed. The double-layer dragon fruit planting method adopts planting frames on the premise that the dragon fruit growth requirement is met and fully utilizes land resources and light conditions, the acre yield, quality and sweetness of dragon fruits are improved, and the economic benefits of dragon fruit planting are increased.

A medication having nicotinamide mononucleotide as the active ingredient, and the use of nicotinamide mononucleotide in preparing medications for the prevention and treatment of arteriosclerosis and cardiovascular and cerebrovascular diseases caused by arteriosclerosis.

The invention discloses an identification method for the clubroot resistance of alpine radish at the seedling stage. The identification method is characterized by comprising the following steps: S1, sieving soil of cultivated land, adding with a fertilizer and plant ash, mixing sterile soil with an organic fertilizer and calcium superphosphate, in addition, adding with plant ash, and preparing culture soil; S2, taking a hole tray as a culture device, adding the culture soil obtained in S1 into the hole tray, and sowing the seeds with the variety to be identified in the hole tray; S3, grinding fungus roots containing plasmodiophoromycetes, filtering the grinded fungus roots by adopting gauze, preparing a pathogenic spore solution, carrying out counting by adopting a blood counting chamber, preparing the spore solution into inoculating bacteria liquid with the concentration being 1x10<7> spores/ml for later use; S4, adding the culture soil into the hole tray for later use; and S5, completely watering the culture soil in the hole tray, when the water settles and the soil is slightly dry and is suitable for sowing, carrying out dibble seeding and earthing at the central point of each hole, establishing a small shed, carrying out normal field management, and investigating the morbidity at the 7th week after inoculation. According to the identification method provided by the invention, through the root irrigation identification method, the clubroot resistance of relevant experimental population can be improved, and thus the method has great values for the disease-resisting breeding practice and theoretical research.

Described herein are compounds useful as agonists of alpha 2B/2C receptors. Pharmaceutical compositions including the presently described compounds and methods of treatment of diseases and conditions with the presently described compounds also are disclosed.

A Chinese traditional medicament for curing acute pharyngitis belongs to a Chinese traditional medicament for curing acute and chronic pharyngitis, comprising rehmanniae radix 20g, liriope and scutellaria separately 15g, figwort 12g, balloonflower 10g, liquorice 6g, oroxylum indicum 10g, honeysuckle 15g, and mint 6g; wherein the assistant medicaments are that the person having throat itching can charge periostracum cicadae 10g, the person having heavy cough can charge fritillaria 10g, and the person whose follicle is scarlet and assumes the clustered pattern can charge weeping forsythia and blackberry lily separately 10g. The invention uses natural Chinese herbal medicaments as the dispensing materials in the prescription and then is made by employing traditional processing method, the materials are easy to obtain, the prescription and the process for preparation are simple, and the charge of manufacturing medicament is low. The Chinese herbal composition is simple, the medicaments used in the medicament prescription are completely natural herbal medicaments, and the obtaining and the utilizing are convenient. The process for preparation is simple, the curing effect after taking the invention is good, and the price of the medicament is low. Especially the invention can be applicable to people reside in remote villages far away from towns. The curing charge is low towards people having acute pharyngitis. The invention solves the problems that the household income is low, the life is poor, and the medical treatment condition for curing in local is lacked.

The present invention includes methods for treating a FLT3 mutated proliferative disorder comprising: measuring expression of a mutated FLT3 and one or more genetic abnormalities in a sample obtained from a tumor sample obtained from the patient, wherein the presence of the one or more genetic abnormalities indicates that the patient has a poor prognosis; and administering to the patient a therapeutically effective amount of crenolanib or a pharmaceutically acceptable salt thereof, wherein the crenolanib increases a chance of survival of the patient having both the mutated FLT3 and the one or more genetic abnormalities, wherein the crenolanib, as shown below, is administered to a subject suffering from said disorder:

The invention discloses an infusion speed and temperature controller, comprising a main microcontroller, a clock module, a speed control module and a temperature control module; wherein, the speed control module is connected with an infusion apparatus control clamp and the main microcontroller; the temperature control module is connected with the main microcontroller. The invention can simultaneously carry out accurate speed monitoring and constant temperature treatment on infused liquid medicines and achieve the aim of safe and reliable infusion, thus being widely applied in infusion rooms, anaesthetic rooms, internal curative departments, and to treatment of cardiovascular and cerebrovascular diseases, tumor chemotherapy and extra-gastrointestinal intravenous fluid infusion, etc.

The invention discloses a plant cultivation bowl and a production method thereof. The plant cultivation bowl comprises a cultivation bowl body, which is a column with one end and the other end closed, and the inner diameter of the closed end is smaller than that of the open end; a movably connected isolating layer is arranged close to the closed end to form a chamber with the closed end; nutrient solution mixed with compound microorganisms is filled inside the chamber; the isolating layer is provided with a plurality of through holes; the cultivation bowl body is formed by pressing bentonite, cattle chip, straw, bean pulp, humic acid and starch; the outer layer of the upper portion of the isolating layer is coated with hydrogel; hydrogel on the outer layer of the cultivation bowl body is coated with degradable plastics. The invention also provides a production method of the plant cultivation bowl. The plant cultivation bowl is degradable and can provide nutrition for plants planted inside the bowl, has the advantages of being high in water resistance and water retaining property and can improve the disease resistance of the plants. The plant cultivation bowl is particularly applicable to improvement of saline-alkali lands in dry regions or saline-alkali regions.

The invention provides a traditional Chinese medicine microbial ecological agent for preventing and treating infectious bursal disease of chicken and a preparation method thereof. The preparation method comprises the following steps: adding water to radix isatidis, honeysuckle, forsythia, folium isatidis, humulus scandens, radix scutellariae, dangshen, ageratum, plantain, astragalus membranaceus, angelica sinensis and liquorice, boiling by using high heat, preserving heat for 30-60 minutes by using slow fire, cooling, filtering, collecting filtrate, adding white sugar, boiling, cooling to a normal temperature, then inoculating lactobacillus, zygosaccharomyces bailii and acetobacter xylinum, and fermenting for 3-7 days so as to obtain the microbial ecological agent. After the microbial ecological agent is diluted proportionally, the diluted microbial ecological agent is directly drunk by chicken. The traditional Chinese medicine microbial ecological agent provided by the invention has the effects of resisting viruses, inducing interferon, increasing the quantity of effective microbial communities in intestinal tracts, boosting immunity and improving disease resistance of chickens without toxic or side effects and the like; the preparation method is simple, convenient to use and high in viable bacteria content and has no residues. The traditional Chinese medicine microbial ecological agent provided by the invention has a certain curative effect on infectious bronchitis and henpox and relatively good market prospect.