7 results about "Arginine" patented technology

The present invention generally relates to the improvement of tissue health by increasing local blood flow. In some aspects of the invention, increased local blood flow is effected by the transdermal delivery of the nitric oxide precursor L-arginine and/or its derivatives alone, or optionally in conjunction with an adjunct such as theophylline. The transdermal delivery is effected, in certain embodiments through the means of a hostile biophysical environment, such as that created by a high ionic strength environment. Various pathological states caused by, or occurring in conjunction with, insufficient blood flow, can be treated using the systems and methods of the invention as described herein. In other embodiments, increased blood flow using the systems and methods of the invention may result in enhanced healing, for example, through greater availability of the constituents of the blood. Examples of conditions which may benefit from increased blood flow include, but are not limited to, erectile dysfunction, hair loss, female sexual dissatisfaction, sagging facial or other body tissue, peripheral vascular disease including claudication, neuropathy, skin ulcers, bone healing, wound healing, viral and bacterial infection, and skin grafting.

The invention discloses a process for producing arginine by microbial fermentation. Brevibacterium flavum MQA121 is adopted. The method comprises the following steps: preparing fermentation liquid, namely performing slant culture, performing shake-flask culture, performing primary seed culture, performing secondary seed culture, and continuing to ferment; extracting and refining a fermented product, namely preprocessing the fermentation liquid, performing secondary crystallization, performing color and impurity removal, performing membrane concentration and separation, drying, and packaging to obtain arginine as a finished product. The method has the benefits that organic and inorganic matters and bacteria in subsequent extracting and refining liquid of arginine can be remarkably reduced and the arginine yield can be increased; in addition, the product quality is improved and the production cost is reduced.

The invention discloses an antibacterial whitening mouthwash and a preparation method thereof. The antibacterial whitening mouthwash comprises an antibacterial component and a mouthwash matrix component, wherein the antibacterial component comprises 0.05 to 0.5 part of lysozyme, 0.01 to 0.5 part of lauryl arginine ethyl ester hydrochloride, 0.01 to 1 part of dextran anhydrase and 1 to 10 parts ofabelmoschus manihot extract. A substrate component of the mouthwash comprises one or more of an emulsifier, a moisturize, a flavoring, an acid-base conditioner and an essence, and the balance is deionized water. Lysozyme and lauryl arginine ethyl ester hydrochloride are dissolved in a citric acid solution and uniformly stirred; the prepared ingredients are mixed with the emulsifier, moisturizer, flavoring and essence evenly, pH is adjusted, and abelmoschus manihot extract and dextran enzyme are added. The invention makes the synergistic effect between the natural antibacterial agent and the chemical antibacterial agent exist, and the mouthwash produced by the invention has high safety and good antibacterial activity, and can effectively prevent and control the occurrence of dental plaque and oral inflammation.

The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the β2/β2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.

The invention relates to the field of pharmaceutical preparation and the technical field of biological medicine, and particularly relates to a functional nano-carrier with a escape capability of lysosome and a preparation method of same. The functional nano-carrier is characterized in that the functional nano-carrier comprises arginine alkyl alcohol ester, medicament, carrier material and water. The functional nano-carrier has intense destructive effect on biological films in the condition of low pH value, so that the functional nano-carrier can rapidly destroy lysosome films in the conditionof acidic condition and rapidly escape into cytoplasm, is prevented from being destroyed by various enzymes and acid environment in lysosome, and is good for the exerting of the drug efficacy.