13 results about "Hydrochloride" patented technology

The invention discloses a method for preparing oxiracetam (4-hydroxylethylpyrrolidone-2-acetamide) used for improving brain functions. The method comprises the following steps: taking chloroacetoacetic ester and aminoacetonitrile hydrochloride (aminoacetonitrile sulphate) as raw materials, and conducting the steps such as hydrogenation, substitution, cyclization and the like on the chloroacetoacetic ester, and finally synthesizing and obtaining the objective product; and the preparation method has the advantages that the price of the raw materials is cheap and the materials are easy to obtain, the cost is low, the technical process is simple, and compared with the prior art, the yield rate is higher, the product quality is better, thus being more suitable for the industrialized scale production.

The invention relates to a method for preparing a test solution for quality detection of a safe stagnation removing preparation. The method comprises the following steps of: (1), extracting solution preparation: weighting 0.5-10.0g of solid safe stagnation removing preparation or contents thereof, adding a universal solvent for extracting alkaloid, carrying out ultrasonic treatment or heating backflow, cooling down, and filtering to obtain a filter liquid as an extract liquid for later use; or weighting 4-80ml of liquid safe stagnation removing preparation, and filtering to obtain the filter liquid as the extract liquid for later use; and (2) extract liquid purification: taking out the extract liquid, drying through steaming, dissolving residues by adding 1-10ml of hydrochloric acid solution (1-5,000) to the residues, centrifuging a mixed solution, taking out supernatant to slowly pass through an octadecylsilane bonded silica gel column (50-500mg), eluting by water of 2-30ml, collecting an effluent liquid and an eluting liquid, drying by steaming, dissolving the residues by adding 1-10ml of methanol with the volume percent of 30-100% or alcohol with the volume percent of 50-95%, standing, and taking out supernatant which is the test solution for a leonurus indexity element stachydrine hydrochloride thin layer discriminating and/or content determining method in the safe stagnation removing preparation.

The invention discloses an antibacterial finishing agent, an antibacterial yarn and a preparation method and application of the antibacterial yarn. The antibacterial finishing agent is prepared from the following components in parts by weight: 5-20 parts of antibacterial agent, 5-25 parts of a cationic colouring stabilizer, 10-30 parts of a cationic softener and 10-30 parts of water-based resin, wherein the antibacterial agent is selected from at least one of N-dodecyl-amino glycine betaine-2-cysteamine hydrochloride, 3-trimethoxysilylpropyl octadecyldimethyl-ammoniu chloride, chitosan biguanidine hydrochloride, polyhexamethylene biguanidine hydrochloride and ammonium dihydrogen phosphate; and the water-based resin is selected from at least one of vinyl acetate emulsion resin, polyvinyl alcohol resin, polymethylacrylic acid and polyethylene oxide. The water-based resin adopting the components is capable of improving the hand feeling and the comfort of the yarn; and through common action of the cationic colouring stabilizer, the cationic softener, the water-based resin and the antibacterial agent at the ratio, the yarn has good antibacterial property, the requirements of performance, such as the color fastness and the hand feeling comfort are coordinated, and meanwhile, the antibacterial property, the color fastness and the comfort of the yarn are ensured.

The invention discloses an antibacterial whitening mouthwash and a preparation method thereof. The antibacterial whitening mouthwash comprises an antibacterial component and a mouthwash matrix component, wherein the antibacterial component comprises 0.05 to 0.5 part of lysozyme, 0.01 to 0.5 part of lauryl arginine ethyl ester hydrochloride, 0.01 to 1 part of dextran anhydrase and 1 to 10 parts ofabelmoschus manihot extract. A substrate component of the mouthwash comprises one or more of an emulsifier, a moisturize, a flavoring, an acid-base conditioner and an essence, and the balance is deionized water. Lysozyme and lauryl arginine ethyl ester hydrochloride are dissolved in a citric acid solution and uniformly stirred; the prepared ingredients are mixed with the emulsifier, moisturizer, flavoring and essence evenly, pH is adjusted, and abelmoschus manihot extract and dextran enzyme are added. The invention makes the synergistic effect between the natural antibacterial agent and the chemical antibacterial agent exist, and the mouthwash produced by the invention has high safety and good antibacterial activity, and can effectively prevent and control the occurrence of dental plaque and oral inflammation.

The invention provides a cotton-fiber anionic modifier, a preparation method thereof and a dyeing process, and belongs to the field of cotton cloth modification dyeing, solving existing problems suchas large pollution caused by using cotton-fiber cationic modifiers to modify cotton cloth. The preparation method of the cotton-fiber anionic modifier is characterized by including the following steps: adding water, crushed ice and melamine into a first beaker, and stirring for 1-2 hours; adding water and p-aminobenzene sulfonic acid into a second beaker, and regulating the pH value by hydrochloric acid to 5-6 to make a solution transparent; adding the p-aminobenzene sulfonic acid hydrochloride in the second beaker into the first beaker, completing dropwise adding within 1-2 hours, keeping thetemperature below 5 DEG C, and carrying out a condensation reaction until the reaction ends; regulating the system pH value by sodium bicarbonate to 7-8; adding 25-40% of neutral salt according to volume to salt out; stirring for 1-2 hours, performing filter pressing, and drying a filter cake. The cotton-fiber anionic modifier has the advantages of small pollution and the like.

The invention discloses a preparation method of a dapoxetine hydrochloride racemate, which comprises the following steps: by using 1-(3-phenylpropoxy) naphthalene as a raw material, carrying out halogenation, amination, hydrogenation dehalogenation and the like to obtain a dapoxetine hydrochloride racemate (V); the method disclosed by the invention is high in yield, convenient in post-treatment and more suitable for industrial production.

The present invention relates to a method for preparing p-menthane-3,8-diol, characterised in that it comprises the following steps:

a. preparation of an aqueous solution comprising between 0.05% and 5% by mass, preferably between 0.05% and 2% by mass, preferentially between 0.05% and 1% by mass, even more preferentially between 0.05% and 0.5% by mass of an ammonium salt, the said ammonium salt being characterised in that it is selected from the group formed by an amino acid ammonium salt, and in particular an amino acid hydrochloride, a vitamin B ammonium salt, and in particular a vitamin B hydrochloride, an ammonium salt of an amino acid ester, and an ammonium salt of a vitamin B ester, or is defined by the following formula (I):

wherein R₁ represents a benzyl, optionally substituted, or R₁ represents an alkyl, either linear or branched, optionally cyclical, saturated or unsaturated, optionally substituted, comprising from 1 to 10 carbon atoms, preferably from 1 to 6 carbon atoms, preferentially from 2 to 4 carbon atoms, and R₂, R₃ and R₄ represent a hydrogen or a methyl group, and X represents a chlorine atom, bromine atom or an OR′ group, R′ being an alkyl group comprising from 1 to 10 carbon atoms,

b. adding of citronellal to the aqueous solution obtained in the step a), and obtaining a mixture;

c. stirring and heating of the mixture obtained in the step b);

d. decanting of the reaction medium obtained at the end of step c) and obtaining at least two phases; and

e. separation of the said at least two phases obtained in the step d), and obtaining at least one aqueous phase and at least one organic phase, the said organic phase comprising at least p-menthane-3,8-diol.

The invention discloses a method for preparing an iguratimod intermediate IV, which belongs to the technical field of medicine and chemical industry. The present invention replaces nitrobenzene with nitromethane as the preparation of Alamod intermediate IV (α-amino-2-methoxy-4-methanesulfonamido-5-phenoxyacetophenone hydrochloride ) solvent, the weight yield of the prepared Alamod intermediate IV can reach 102~105%, and the purity can reach more than 99%; in addition, the present invention adopts nitromethane as the solvent of reaction and also has the following advantages: weak smell , less pollution, less harm to the human body, easy post-processing of the product, improved purity, and no genotoxic impurity nitrobenzene residue in the final product.