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8 results about "Crude drug" patented technology

Crude drugs are vegetable or animal drugs that contain natural substances that have undergone only the processes of collection and drying. The term natural substances refers to those substances found in nature that have not had man-made changes made in their molecular structure. They are used as medicine for human being and animal, internally and externally for curing disease, e.g., Senna and Cinchona.

Method for preparing LCZ696

ActiveCN105330609AReduce generationPrecipitation state is goodOrganic compound preparationOrganic chemistry methodsSodium acetateReaction temperature
The invention discloses a method for preparing LCZ696. Please see the synthesis route in the specification. When sodium acetate is used as alkali in the compound III preparation process, the conversion rate is high, hydrolysis impurities are few, system stability is good, and the reaction time is greatly shortened; in the compound I preparation process, acetone and normal heptanes with the mass ratio between 5 to 1and 10 to 1 serve as cocrystallization solvent, the reaction temperature of 35-45 DEG C is adopted, a sodium hydroxide solution is dropwise added into a reaction system at a certain speed at the temperature of 35-45 DEG C, generation of hydrolysis products can be greatly reduced, the solid precipitation state is good, purity is high, aminolysis impurities and hydrolysis impurities can be effectively controlled, and the LCZ696 can directly serve as crude drug to be used for preparations.
Owner:NANJING CHIA TAI TIANQING PHARMA +1

Method for extracting fucoidan polysaccharide sulfate

ActiveCN103980373ASolve difficult problems that are not suitable for separationSimple extraction processOrganic active ingredientsMedicineMicrobiology
The invention relates to a novel extraction method of a plant crude drug, namely a method for extracting fucoidan polysaccharide sulfate. The name of the preparation commodity is a haikun shenxi capsule. The method comprises the following main extracting steps: (1) adding 10-fold water to a dried kelp to soak for 8 hours, controlling room temperature at 8-32 DEG C, taking a soak solution to be concentrated into 1/5 of original volume for later use, and separating out alginate on the surface of a marine organism by adopting the step; (2) taking out and cutting up the soaked kelp, and homogenating by using an AH high-pressure homogenizer; (3) adding sodium hydroxide to homogenated liquid to adjust the pH value to 12, stirring for 30 minutes, standing for 12 hours, adjusting the pH value to 1.5-2 by using a hydrochloric acid, stirring for 8 hours, and standing for 12 hours; (4) filtering; (5) merging filtrate with a concentrated solution in the step (1) and desalting by adopting specific 500 electroosmosis; (6) concentrating and decoloring soup; (7) centrifuging, and washing a filter cake by using 95% ethanol; (8) drying and crushing a dry substance. The yield is improved, and the cost is reduced. Compared with the prior art, the yield of the method is improved by over 40% by detection.
Owner:吉林省辉南长龙生化药业股份有限公司

Preparation method of sodium ibandronate

InactiveCN102898466AEasy to operateMeet the quality requirements of raw materialsGroup 5/15 element organic compoundsSkeletal disorderPhosphorous acidChlorobenzene
The invention relates to the technical field of pharmaceutical chemistry, particularly relates to a method of pharmaceutical synthesis, and specifically relates to a preparation method of sodium ibandronate. To overcome the disadvantages of high content of chlorides and phosphites in sodium ibandronate prepared by a conventional preparation method of sodium ibandronate, the preparation method of sodium ibandronate with extremely low content of chlorides and phosphites is provided. In the preparation method, 3-(N-methylpentylamino) propionic acid hydrochloride, phosphorus trichloride and phosphorous acid are employed as raw materials and reacted in a chlorobenzene solvent, so as to obtain sodium ibandronate with extremely low content of the chlorides and the phosphites. The obtained sodium ibandronate can not only meet impurity control standards of the chlorides and the phosphites in a sodium ibandronate crude drug, but also prevent low yield, long period and huge harm to human body and environment which are brought by a lot of refining steps.
Owner:JIANGSU AOSAIKANG PHARMA CO LTD

Medicine composition for treating psoriasis

InactiveCN106902258AAnthropod material medical ingredientsPill deliveryRealgarPsoriasis universalis
The invention discloses a pharmaceutical composition for treating psoriasis, which is composed of 23 raw materials such as vitex, nepeta, pangolin, snail, alum, realgar, catechu, gypsum, angelica, and frankincense. The pharmaceutical composition of the present invention is prepared into any clinically acceptable dosage form by adding conventional auxiliary materials according to conventional techniques. The pharmaceutical composition of the invention has remarkable effect on treating psoriasis, treats both symptoms and root causes, has low recurrence rate, moderate cost and can be accepted by common patients.
Owner:邵杰
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