58results about "Pill delivery" patented technology

The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt, solvate, ester, and/or prodrug thereof, an ionic non-gelling matrix polymer, and a pH modifier. The ionic non-gelling matrix polymer is practically insoluble and unswellable at a first aqueous fluid pH and is soluble at a second aqueous fluid pH. The pH modifier is present in an amount to control the release of the active agent from the composition. The controlled-release composition is substantially free of a gelling or swellable excipient. The present invention also provides methods of making and using the controlled-release compositions.

A health-care food in the form of soft-capsule, capsule, particle, tablet, or oral liquid for improving immunity and preventing and treating the injury of stomach mucosa is proportionally prepared from the oil of seabuckthorn fruit and the extract of propolis through mixing and shaping.

A particulate co-processed composition comprising microcrystalline cellulose and at least one sugar alcohol is disclosed. A preferred sugar alcohol is mannitol. The composition has an improved compactability profile, lubricant sensitivity, and ejection profile compared to microcrystalline cellulose and the at least one sugar alcohol, either alone or in combination as a simple dry blend, in the preparation of solid dosage formulations, such as tablets. Tablets comprising the particulate co-processed composition, an active, and, optionally, one or more other excipients, and method for their preparation, are also disclosed.

A chewing spirulina tablet is prepared from spirulina and two or more of dextrin, microcrystalline cellulose, mannitol, xylitol, aspartame, glycyrrhizin, essence powder, superfine silica gel powder, and magnesium stearate through mixing, granulating by use of alcohol solution containing polyvitone K30, drying and die pressing.

The invention provides a preparation method of an LCZ696 sustained release matrix tablet. The specific prescription of the LCZ696 sustained release tablet comprises (g/g): 40% of a main drug, 10%-20% of a matrix material, 30%-40% of a diluent, and 5%-10% of a lubricant. The preparation method consists of: sieving the raw and auxiliary materials by a 80-mesh sieve respectively for standby use, firstly mixing the main drug with the matrix material evenly, then adding the diluent and the lubricant and mixing the materials evenly, and performing all powder direct compression, thus obtaining the LCZ696 sustained release matrix tablet. The sustained release tablet is used for medication once every 24h, and the number of medication times is reduced. After oral taking, drugs are released slowly, the blood concentration is stable, and peak valley phenomenon is not generated. Also, the toxic and side effects of drugs are reduced.

The present invention relates to compressed tablets for peroral delivery of the cannabinoid cannabidiol (CBD). More particularly, the invention provides a compressed tablet having a tablet weight of 60-1200 mg, said tablet being composed of: 50-95 wt. % of a granulate; 5-50 wt. % of lactose; and 0-30 wt. % of other tablet excipients; wherein the granulate contains: a.2-15 wt. % of cannabidiol; b.2-30 wt. % of sucrose fatty acid mono-ester; c.30-96 wt. % of lactose; and d.0-25 wt. % of other granulate excipients. The compressed tablets according to the invention can conveniently be used in the treatment of psychosis disorders or anxiety disorders. The invention further provides a method for the manufacture of the compressed tablets.

The invention discloses a medicinal pills containing stomach dissolving and intestine dissolving portions, wherein the stomach dissolving portion comprises astragalus root 4-12 parts, pilose asiabell root 4-15 parts, amomum fruit 1-7 parts, white peony root 7-17 parts, Chinese angelica root 1-14 parts, white atractylodes rhizome 5-12 parts and cinnamon 1-7 parts, intestine dissolving portion comprises rhizoma corydalis 5-13 parts, lychee seed 5-10 parts, dried ginger 1-4 parts, licorice root 5-12 parts, ledebouriella root 2-7 parts, banksia rose 2-6 parts, psoralea fruit 1-6 parts and red halloysite 7-17 parts.

The invention relates to an azithromycin dispersible tablet and a preparation method thereof. The azithromycin dispersible tablet is prepared by the following steps: by adopting a fluid bed bottom spraying technology, coating azithromycin by using a suspension of calcium carbonate and a water-insoluble macromolecular polymer to prepare an azithromycin microcapsule; and then uniformly mixing the azithromycin microcapsule with other pharmaceutically acceptable auxiliary materials of the azithromycin and tabletting, wherein the water-insoluble macromolecular polymer is selected from one or more of acrylic resin, ethyecellulose and hydroxypropyl methylcellulose phthalate. Compared with the prior art, the azithromycin dispersible tablet disclosed by the invention has the advantages of good taste, fast dissolution and simple preparation process.

Dispersing Qingkailing tablet as one pure Chinese medicine preparation has obvious curative effect on viral cold, acute tonsillitis, acute pharyngitis, acute bronchitis, high fever, etc. It has the functions of clearing away heat and toxic material and tranqilizing, and may be also used in treating high intracranial pressure disease, hydrocephalus, cerebral vascular dementia and other diseases. The medicine has high bioavailability, fast absorption and taking convenience. The present invention features that the dispersing Qingkailing tablet is prepared with eight kinds of Chinese medicinal materials, including cholic acid, baicalin, cape jasmine, isatis root, hyodeoxycholic acid, etc. as well as ten kinds of supplementary material, and through soaking, decoction, filtering, concentrating, deposition, crushing, drying, palletizing, finishing and other steps.

A dispersing tablet of Xindakang with high solubility and disintegrating speed for treating ischemic heart disease, arrhythmia, hypertension, hyperlipemia, hyperviscosity blood, etc is prepared from flavone acetylsalicylate and proper additive. Its preparing process is also disclosed.

The invention relates to a Chinese medicinal preparation for treating spermophlebectasia, wherein the reactive constituents are prepared from the following raw materials (by weight portion): ledebouriella root 6-12, dahurian angelica root 6-9, dried orange peel 8-10, red peony root 6-9, Chinese angelica root 9-12, pangolin scales 9-12, Chinese honey locust 9-12, myrrh 3-5, licorice root 4-6, honeysuckle flower 10-15, root of Chinese trichosannthes 10-15, bupleurum root 4-6, Sichuan fritillary bulb 9-12, frank incense 3-6, phellodendron bark 8-10, plantain seeds 8-10. The medicament can be prepared into dose forms of oral liquids, capsules, tablets, pills or powders.

The invention discloses a traditional Chinese medicine composition, a preparation thereof and a preparation method of the preparation. The traditional Chinese composition is prepared from turtle shell, Morinda officinalis, dogwood, the bark of eucommia, fructus psoraleae, herba cistanche, cynomorium songaricum, glossy privet fruits, teasel roots, ginseng, radix angelica sinensis, Caulis Spatholobi, the root of red-rooted salvia, peach seeds, safflower carthamus, pseudo-ginseng, rhizoma sparganii, curcuma zedoary, leeches, the rhizome of chuanxiong, the root of bidentate achyranthes, rhizoma curcumae longae, woodlouses, processed monkshood, radix aconiti preparata, prepared kusnezoff monkshood root, herba ephedra, Asarum delavayi, cassia twigs, clove, radix angelicae dahurioae, centipedes, scorpions, rhizoma corydalis, prepared nux vomica, gastrodia elata, long-noded pit viper, lumbricus, rhizoma anemarrhenae, cortex acanthopanacis, homalomena occulta, radix rehmanniae, pawpaw, akebiaquinata, fructus amomi, amur cork-tree, radix angelicae pubescentis, drynaria rhizome, common threewingnut root, the dried root and stem of Dioscorea septemloba Thunbt and Dioscorea hypoglauca Palibin and rhizoma atractylodis. The traditional Chinese medicine composition can effectively cure bone diseases such as knee joint effusion and rheumatic arthritis.

The invention discloses cassia twig and poria cocos pills and a preparation method thereof. The cassia twig and poria cocos pills are prepared from, by weight, 190-210 parts of cassia twigs, 190-210 parts of poria cocos, 190-210 parts of cortex moutan, 190-210 parts of radix paeoniae rubra and 190-210 parts of peach kernels. The cassia twig and poria cocos pills have the effects of promoting blood circulation to remove blood stasis and relieving and eliminating lumps and can be used for treating symptoms of blood stasis retention in uterus, gestation threatened abortion, endless metrostaxis, uterine fibroid, endometriosis, ovarian cyst, annexitis and chronic pelvic inflammation; meanwhile, the cassia twig and poria cocos pills have the advantages of being reasonable in cost, small in toxic and side effects, convenient to take and short in curative effect; the cassia twig and poria cocos pills can be produced in a batched mode, are wide in appropriate people and have extremely high popularization value.

The invention discloses an amoxicillin orally disintegrating tablet and a preparation method thereof. The orally disintegrating tablet comprises the following raw materials in parts by weight: granulation raw materials: 10 to 15 parts of amoxicillin, 1 to 3 parts of colloidal silicon dioxide, and 0.5 to 1 part of povidone K30; granulation auxiliary materials: 4 to 8 parts of microcrystalline cellulose, 0.2 to 0.6 part of aspartame, and 0.4 to 0.8 part of croscarmellose sodium; external auxiliary materials: 0.4 to 0.8 part of croscarmellose sodium, 0.1 to 0.2 part of magnesium stearate, and 0.4 to 0.8 part of orange flavor. The disintegrating tablet has the effects that an object product has stable characters through a reasonable formula, and specific dosage ratio and constituents among all the components, the disintegration time meets expectation, and contents of relevant matter and amoxicillin meet the requirements of standards.

The present invention discloses a composition of a hydrogel type polymer with improved disintegration performance, wherein the composition contains one (or a variety of) hydrophilic polymer I and a hydrophilic polymer II with 1.5 times or more the AAP value of the hydrophilic polymer I. The invention further discloses a preparation (with improved drug release property (stability), especially a hydrophilic slow-release (/controlled-release) preparation), which contains one (or a variety of) drug, the composition of the hydrogel type polymer, and an optionally pharmaceutically acceptable formulaagent. According to the present invention, the damage on the drug release (especially slow-release (/controlled release)) from the preparation by the ion intensity (salinity) of the release medium isneutralized, such that the complete-dose preparation release under the eating condition or the substantially no release under the fasting condition along the whole gastrointestinal tract can be prevented in the release medium with the changed ion intensity or the high-salinity.

The invention discloses traditional Chinese medicine pills for treating puerperal uterine subinvolution and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The active ingredients of the traditional Chinese medicine pills consist of the following raw materials: Chinese date, root of sandhill tylophora, Chinese yam, dried longan pulp, rehmannia root, heterophylly faalsestarwort root, root of silverweed cinquefoil, herb of bifurcate cinquefoil, stem of noble dendrobium, mulberry fruit, manyflower solomonseal rhizome, chinese granesbill, cowpea, lalang grass rhizome, rhizoma corydalis, medicinal cyathula root, giant knotweed rhizome, motherwort herb, red rice, diverse wormwood herb, India madder root, curcuma longa, licorice root and crocus sativus. The drug properties of the medicinal materials for preparing the traditional Chinese medicine pills disclosed by the invention supplement with one another, and the traditional Chinese medicine pills are applied according to indications, has the effects of reinforcing the spleen to replenish qi, reinforcing the kidney to control bleeding, nourishing yin to tonify blood, cooling blood to stop bleeding, promoting blood circulation to remove blood stasis, breaking blood to promote the circulation of qi and inducing menstruation to stop pain, is good in absorption effect and significant in curative effect, does not have toxic or side effects and clinical adverse reactions, and is clinically verified to have a relatively high curative rate for treating the puerperal uterine subinvolution.

The invention discloses a tablet for treating influenza and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparation. The tablet comprises starch, gypsum, crystal sugar, honey, magnesium stearate and a traditional Chinese medicine preparation. The tablet is prepared through the steps of crude product preparing, drying, sterilizing and the like. The tablet for treating the influenza integrates the effects of multiple traditional Chinese medicines, can achieve the effects of clearing heat, removing toxicity, inhibiting acute inflammation, eliminating phlegm, inhibiting bacteria, resisting virus and the like, and is rapid to take the effects, significant in treatment effect, safe and stable in medicine effect, high in cure rate and free of any side effects; the tablet is sterilized at high temperature under high pressure and is short in time, good in effect and long in preservation time.

Gastric retentive dosage forms for controlled release of polypeptides are described. Methods of treatment using the dosage forms and methods of making the dosage forms are also described.

The present invention discloses a new application of a composition of phillyrin and phillygeninin in the preparation of drugs for alleviating or/and treating viral diseases. Experiments prove that the composition of phillyrin and phillygeninin has significant treatment effects on viral influenza and pneumonia, as well as on respiratory syncytial viruses, enteroviruses, herpes zoster simplex viruses, Coxsackie viruses, and the like. This composition is characterized by quick action and less toxic and side effects, and thus is an antiviral drug and health product with safety, high efficiency, stability and simple preparation process, and is suitable for industrial production and easy to promote. The present invention provides a new drug, health product and raw material for preventing and treating various viral diseases.

The invention provides a traditional Chinese medicine for treating yin-deficiency fire-hyperactivity type neurasthenia and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicinal materials: citron fruit, herb of involucrate balanophora, herb of triquetrous tadehagi, root of beechey fig, dark brown part in licorice root, cholla stem, ziziphora bungeana, lethariella cladonioides, plum flower, officinal asparagus root, herb of common ammannia, bark of mongolian oak, entada sten, hairypistil acanthpanax, seed of chingma abutilon, creeping pothos and bulb of longroot onion. The traditional Chinese medicine provided by the invention has the advantages of strong pertinence, obvious curative effect and small side effects for treating the yin-deficiency fire-hyperactivity type neurasthenia.