38results about "Granular delivery" patented technology

The present invention relates to a resin composition comprising a resin and apatite, wherein referring to the particulate form of said apatite present in the resin composition thus obtained, the apatite is present in a particulate form having an average diameter or average thickness (d) of not greater than 100 nm and an average aspect ratio (L/D) of not smaller than 5 as defined by the ratio of the average length (L) to said average diameter or average thickness (d).

The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include non-temperature dependent phase change compositions that may be formulated as solutions, solids, semisolids, microparticles, or crystals.

A particulate co-processed composition comprising microcrystalline cellulose and at least one sugar alcohol is disclosed. A preferred sugar alcohol is mannitol. The composition has an improved compactability profile, lubricant sensitivity, and ejection profile compared to microcrystalline cellulose and the at least one sugar alcohol, either alone or in combination as a simple dry blend, in the preparation of solid dosage formulations, such as tablets. Tablets comprising the particulate co-processed composition, an active, and, optionally, one or more other excipients, and method for their preparation, are also disclosed.

The invention discloses an O type foot and mouth disease virus-like particle vaccine as well as a preparation method and an application thereof, and belongs to the fields of genetic engineering and immunology, aiming at solving the problems of an existing inactivated foot and mouth disease vaccine which is poor in safety and unsatisfying in use effect. The amino acid sequence of the vaccine is shown as SEQ ID NO: 1 in a sequence list, and a nucleotide sequence for encoding the amino acid sequence is shown as SEQ ID NO: 2 in the sequence list. After being immunized, the vaccine can induce an animal to simultaneously generate an O type foot and mouth disease resistant antibody; the vaccine exists in the form of virus-like particles, and foot and mouth disease virus VP1 epitope locates on the surface of the virus-like particles. According to the invention, the amino acid sequence constituting the virus-like particle vaccine and the nucleotide sequence for encoding the amino acid sequence are provided, and the nucleotide sequence contains all genes of coat protein which can be self-assembled as the virus-like particles in expression. The preparation of the O type foot and mouth disease virus-like particle vaccine disclosed by the invention is good in safety and free from the probability of reversion or toxin dispersion; and the vaccine is long in immunizing validity period and convenient in transportation and storage.

The invention discloses a cactus freshly-squeezed spray dried granule decoction piece and a preparation process thereof. The process includes the steps of firstly, harvesting, selecting and drip washing cactus medicine materials, squeezing the materials freshly, and filtering medicine juice; secondly, adding water to decoction dregs to be stirred, and conducting filtering and squeezing; thirdly, combining obtained medicine juice, conducting decompression concentration and spray drying, collecting spray-dried products, conducting smashing, medicine juice primary squeezing and mixing to prepare granules, and conducting vacuum packaging after granulation. The cactus granule decoction piece prepared through the method keeps the polar and non-polar effective ingredients in the medicine materials to the maximum extent. The granule decoction piece is high in mobility, beneficial to storage and transportation, convenient to adjust, controllable in quality and reliable in curative effect and has important significance in ensuring the traditional Chinese medicine clinical curative effect; the method is implemented and popularized and has remarkable social significance and economic benefits.

The invention relates to a zinc oxide-based nano-drug composition, and a preparation method and an application thereof. The preparation method of the composition comprises the following steps: 1, mixing a sodium hydroxide and/or potassium hydroxide-alcohol solution and a zinc acetate-alcohol solution to obtain a zinc oxide colloid reaction solution; 2, taking the zinc acetate-alcohol solution, simultaneously or successively adding the zinc acetate-alcohol solution and the drug molecule-containing sodium hydroxide and/or potassium hydroxide-alcohol solution to the zinc oxide colloid reaction solution obtained in step 1; and 3, centrifuging a mixed solution obtained in step 2, removing the obtained supernatant, washing the obtained material, purifying the washed material, and drying the purified material to prepare the composition. Zinc oxide is compounded with the drug through directly using the self properties of zinc oxide and the drug, and no polymer is introduced, so the synthesis method is simple and effective. The prepared composition has good dispersibility, the hydrodynamic size is 40-90nm, and the composition has the characteristics of high bioavailability, low toxicity and degradability.

The invention provides a preparation method of capsules capable of activating blood and stopping pains. The preparation method comprises the following steps: taking six types of medicinal materials including 22g of Chinese angelica, 44g of radix notoginseng, 44g of vinegar processed frankincense, 11g of borneol, 111g of ground beetles and 67g of calcined pyrite; adding water with the weight which is 10 times as much as that of the medicinal materials; immersing for 0.5h and decocting for 1 hour; filtering and adding water with the weight which is 8 times as much as that of the medicinal materials into medicine residues; decocting for 1 hour and filtering medicine liquid; combining decocted liquid of the two times and concentrating until the relative density is 1.05 at 60 DEG C; adding ethanol until the volume percent of alcohol content reaches 75 percent; stirring, standing and filtering; concentrating filtrate until the relative density is 1.25 at 65 DEG C; recycling the ethanol to obtain a concentrated solution; carrying out super-critical extraction to obtain super-critical extract; continually concentrating and drying the concentrated solution; granulating and filling the capsules to obtain the capsules capable of activating blood and stopping pains. By adopting specific concentration and drying equipment, the prepared capsules capable of activating blood and stopping pains have high content of ferulic acid and can be applied to preparation of medicines for inhibiting Vero-E6 cell proliferation of African green monkey kidneys.

The present disclosure relates to capsules having a core and one or more capsular walls surrounding the core, wherein at least one of the capsular walls comprises a polymer comprising epsilon-poly-lysine or a derivative thereof.

The present invention provides a micro pill of grape seed extract, prepared from grape seed extract and auxiliary medical materials. The present invention is characterized in that the auxiliary medical materials are excipient and adhesive; the weight percentage of grape seed extract in the micro pill is 2 to 80 percent; the weight percentage of excipient is 25 to 95 percent and that of adhesive is 1 to 5 percent. The micro pill provided by the present invention has the advantages of high leaching rate, high bio-utilization, simple preparation method, and convenient and easy operation.

The present invention relates to nanoparticles for encapsulating compounds, the preparation and uses thereof, comprising a casein matrix, a basic amino acid and a metal selected from a divalent metal, a trivalent metal and combinations thereof. Said nanoparticles can encapsulate a water soluble or fat soluble biologically active compound. The invention is applicable in the food, pharmaceutical and cosmetic sectors and in the nanotechnology sector.

The invention discloses traditional Chinese medicine bath antibacterial liquid/granules for regulating the Yang-deficiency constitution and a preparation and using method. The traditional Chinese medicine bath antibacterial liquid/granules are prepared from, by weight, 5-35 parts of rhizoma cibotii, 5-35 parts of fructus litseae, 5-35 parts of fructus cnidii, 5-35 parts of cassia twig, 5-35 partsof perilla leaves and 5-50 parts of tremella fuciformis. The preparation method comprises the steps that the tremella fuciformis is smashed into superfine tremella fuciformis powder; the other medicine materials are mixed and decocted by adding water, and then filter liquor is collected; the superfine tremella fuciformis powder is added into the filter liquor to obtain a mixture, the mixture is decocted and then concentrated into thick liquid with the relative density of 1.05-1.25, and the thick liquid is filtered to obtain the traditional Chinese medicine bath antibacterial liquid; the traditional Chinese medicine bath antibacterial liquid is further prepared to obtain the antibacterial granules. The traditional Chinese medicine bath antibacterial liquid/granules can effectively regulatethe Yang-deficiency constitution, and therefore, the aims of building the body and preventing diseases are achieved.

The invention discloses a preparation method for a Ganhaiweikang preparation. The preparation method comprises the following steps: picking, cleaning and extracting six components such as liquorice root and sea-buckthorns, drying extracted thick paste in vacuum, grinding the thick paste into fine powder, adding fine powder of cuttlebones and gypenosides and an appropriate amount of starch to prepare granules, drying the granules at a temperature lower than 60 DEG C, uniformly mixing the granules, filling capsules with the granules to obtain 1000 capsules, packaging the capsules with aluminum plastic to obtain the Ganhaiweikang preparation. According to the main active ingredient content measurement and the efficacy evaluation, the Ganhaiweikang capsule prepared by the invention can be improved in active ingredient content, lowered in product dose and improved in product curative effect.

By mixing ibuprofen and a disaggregating agent, the invention involves using these components in a proportion ranging between 96% and 97% by weight for ibuprofen, and between 3% and 4% for the disaggregating agent, which may be Sodium croscarmellose, Crospovidone or Sodium carboxymethyl starch, as well as a mixture thereof. Following the mixing of the raw materials, the mixture is subjected to compaction, granulation and subsequent compression, in order to finally give the tablet a coating; this leads to a significant cost reduction and a significant reduction in the active principle release time, such that the pharmacological action is very fast in time.

The invention provides a traditional Chinese medicinal composition capable of relieving cough and asthma and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition is prepared from the following components in percentage by weight: 5-7 % of fructus momordicae, 5-7 % of exocarpium citri tangerinae, 5-7 % of semen torreya, 5-7 % of flos sophorae immaturus, 5-7 % of perilla seeds, 5-7 % of radix platycodi, 7-9 % of semen ginkgo, 8-10 % of rhizoma dioscoreae, 8-10 % of lily bulbs, 5-7 % of fructus phyllanthi, 5-7 % of semen sterculiae lychnophorae, 7-9 % of apricot kernels, 4-6 % of pericarpium citri reticulatae, 5-7 % of herba houttuyniae, 3-5 % of honeysuckle flowers, and 4-6 % of fructus citri sarcodactylis. The preparation method comprises the following steps: mixing the components, adding water into the mixed components, decocting the components till paste is obtained, carrying out mixed granulation on the paste, maltodextrin and potassium sorbate, carrying out drying, and carrying out sterilizing, thus obtaining the traditional Chinese medicinal composition. The traditional Chinese medicinal composition has the functions of relieving cough and reducing sputum, as well as relieving asthma and relieving exterior syndrome, is mild in property, is free of toxic and side effects, has the outstanding features of treating both symptoms and root causes, being good in long-term effect, and being low in recurrence rate, and has the good treatment effects for the long-term repeated upper respiratory infection, cough and asthma.

The invention discloses a feed additive enteric-coated sustained-release pellet with a function of preventing and treating poultry respiratory syndromes and a preparation method for the feed additive enteric-coated sustained-release pellet. The enteric-coated sustained-release pellet is prepared from the following raw materials: water-soluble vitamin A, water-soluble vitamin D, water-soluble vitamin E, thymol, cinnamyl aldehyde, menthol, eucalyptus oil, maltodextrin, sodium carboxymethylcellulose, lactose and a coating solution which is a Eudragit enteric-coated coating solution with a model of Eudragit L30D-55, wherein the coating solution is water suspension with mass concentration of 5%-8%. The feed additive enteric-coated sustained-release pellet with the function of preventing and treating poultry respiratory syndromes disclosed by the invention has a treatment effect on sick chicken with respiratory syndromes due to artificial infection of chicken infectious bronchitis virus (M41 strain), can effectively improve the respiratory tract function, is small in dosage, quick in effect-taking, and has the effects of promoting growth and increasing a feed conversion rate.

The invention provides an HIV-1 integrase inhibitor phospholipid complex, a preparation method and applications thereof, wherein a mass ratio of the HIV-1 integrase inhibitor to the phospholipid is 1:1-20. According to the present invention, the complex formed by HIV-A5 and phospholipid can effectively improve the hydrophilicity and the lipophilicity of drugs, the phospholipid has good biologicalaffinity, the in vivo absorption capacity is improved, and the bioavailability is improved.

The invention discloses a reagent for treating common cold and fever with the capabilities of dispelling wind and cold. The reagent is prepared from the following main medicinal raw materials in parts by weight: 5-9 parts of leaf of black henbane, 9-15 parts of willowleaf swallowwort rhizome, 15-20 parts of radix puerariae, 9-15 parts of garden burnet root, 8-16 parts of cordate houttuynia, 6-10 parts of root of threeleaf cayratia, 10-15 parts of Indian stringbush root, 5-10 parts of root of West szechwan hogfennel, 8-12 parts of liquorice, 8-16 parts of herb of tropic ageratum, 9-15 parts of common andrographis herb and 7-12 parts of all-grass of delavay pararuellia. As the raw herbal medicines are in compatibility by syndrome differentiation and are supplemented with each other in the actions, the reagent has the efficacies of relieving exterior syndrome, dispelling wind, clearing heat, removing toxicity, regulating qi and discharging fire, is remarkable in curative effect of treating the common cold and the fever and reliable in action and does not have side effect.

The invention provides a method for preparing an adhesive solution in a wet granulation process. The formula of the adhesive solution comprises 1.0-10.0 parts of sodium hydroxide, 24.8-50.0 parts of meglumine, 36.0-73.0 parts of poloxamer P407 and water, and the mass of the water is 19-60 times that of the poloxamer P407. The method comprises the following steps: firstly, respectively dissolving poloxamer P407 and sodium hydroxide with water to obtain a poloxamer P407 aqueous solution and a sodium hydroxide aqueous solution; and mixing the poloxamer P407 aqueous solution and the sodium hydroxide aqueous solution, adding meglumine into the mixture, and stirring the mixture to obtain an adhesive solution. The adhesive solution containing the poloxamer P407, the meglumine and the sodium hydroxide is obtained by the method, the solution is clear and transparent, and the dissolution end point of the solution is easier to judge when raw auxiliary materials or active drugs of other prescription components are subsequently dissolved, so that great convenience is brought to judgment of the dissolution end point.

The present invention relates to a tea particle for strengthening the stomach and eliminating intestinal parasites. The present invention is characterized by extracting a concentrated solution from dark plum, dried orange peel, barley sprout, betelnut and emblic leafflower; adding glucose powder, crystal maltitol and fruity spice into the concentrated solution for fully and evenly stirring; then granulating, drying and sterilizing the mixture, thus obtaining the particle.

The invention discloses a radix paeoniae alba fresh extraction spray drying granule decoction piece which is mainly characterized in that radix paeoniae alba is washed while fresh, cut into prices, juiced and extracted after being harvested, an extraction solution is subjected to spray drying after concentration, and granulation, granule neatening and vacuum packaging are performed. The water content of the granule decoction piece is less than 10%. The decoction piece is stable in quality, can be added to decoction for boiling, can be directly added into capsules and tablets, and is convenientto carry and use clinically.

Dry powder formulations for inhalation and their use in the treatment diseases and conditions. The formulation contains a uniform blend of a first spray-dried powder and a second spray-dried powder. The first spray-dried powder contains spray-dried particles of a therapeutically active ingredient dispersed in a pharmaceutically acceptable hydrophobic excipient. The second spray-dried powder contains spray-dried particles formed from a pharmaceutically acceptable hydrophobic excipient but are substantially free of any therapeutically active ingredient. The active ingredient in the first spray-dried powder is loaded sufficiently high to compensate for the second spray-dried powder being substantially free of any active ingredient. A process for preparing such formulations is also described.