Grape seed extract micropills and preparation thereof

[0033] Take the following ingredients for the recipe

[0034] grape seed extract

5g (based on pure product)

microcrystalline cellulose

97g

Hydroxypropylmethylcellulose

6g

[0035] Prepare pellet formulations as follows:

[0036] (1) Add the grape seed extract of the above-mentioned formula amount to microcrystalline cellulose, pulverize it to a micronized level with a ball mill, and mix well;

[0037] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0038] (3) The extrusion-spheronization method is used to make pellets.

[0040] Take the following ingredients for the recipe

[0041] grape seed extract

40g (based on pure product)

sucrose

55g

Polyvinylpyrrolidone

5g

[0042] Prepare pellet formulations as follows:

[0043](1) Take the grape seed extract of the above-mentioned formula amount and add sucrose, pulverize it to a micronized level with a ball mill, and mix well;

[0044] (2) polyvinylpyrrolidone is dissolved in water;

[0045] (3) Micro-pills were made by pan-pill method.

[0047] Take the following ingredients for the recipe

[0048] grape seed extract

60g (based on pure product)

[0049] sucrose

25g

starch

11g

Polyvinylpyrrolidone

4g

[0050] Prepare pellet formulations as follows:

[0051] (1) Take the grape seed extract of the above formula amount, add sucrose and starch, pulverize to micronized level with a ball mill, and mix well;

[0052] (2) polyvinylpyrrolidone is dissolved in water;

[0053] (3) The pellets are made by the centrifugal-fluidized pelletizing method.