Method for preparing adhesive solution in wet granulation process

A binder solution, wet granulation technology, applied in the field of pharmacy, can solve the problems of complex binder components, difficult realization of clear solution, poor water solubility, etc.

Pending Publication Date: 2021-11-05
上海合全医药有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Generally speaking, the water solubility of most APIs is relatively poor. In order to promote the dissolution of the API, the general adhesive system will contain a variety of excipients, such as the surfactant poloxamer P407, the pH regulator

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing adhesive solution in wet granulation process
  • Method for preparing adhesive solution in wet granulation process
  • Method for preparing adhesive solution in wet granulation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] It is weighted 450 g of purified water, and the purified water is stirred to form a vortex, weigh 25.4 g of the poloxham P407, and the stirred water is slowly added, stirred to form a uniform transparent solution. The purified water of 25 g was added, 0.7 g NaOH was added, stirred until dissolved. The aqueous sodium hydroxide solution was slowly added to a container containing a water solution of a water, and a beaker of the NaOH solution was dissolved with 25 g of water, and 17.4 g of glucamine was added, then 17.4 g of glucamine, continued to stir up and finally obtained a clear clear clarification. Solution (see figure 1 3 cups).

Embodiment 2

[0039] Example 2 Comparison of clarity

[0040] The solution obtained from the Solution 1, 2, 3 and Example 1 was placed in the absorbent tank of the spectrophotometer, and the absorbance was determined at 550 nm, and the results were shown in Table 1 and image 3 .

[0041] Table 1, 4 samples of ultraviolet visible light absorbance and relative turbidity at 550 nm

[0042]

[0043] The test results indicate that the solution obtained in Example 1 was crystal clear, and the difference was significant.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a method for preparing an adhesive solution in a wet granulation process. The formula of the adhesive solution comprises 1.0-10.0 parts of sodium hydroxide, 24.8-50.0 parts of meglumine, 36.0-73.0 parts of poloxamer P407 and water, and the mass of the water is 19-60 times that of the poloxamer P407. The method comprises the following steps: firstly, respectively dissolving poloxamer P407 and sodium hydroxide with water to obtain a poloxamer P407 aqueous solution and a sodium hydroxide aqueous solution; and mixing the poloxamer P407 aqueous solution and the sodium hydroxide aqueous solution, adding meglumine into the mixture, and stirring the mixture to obtain an adhesive solution. The adhesive solution containing the poloxamer P407, the meglumine and the sodium hydroxide is obtained by the method, the solution is clear and transparent, and the dissolution end point of the solution is easier to judge when raw auxiliary materials or active drugs of other prescription components are subsequently dissolved, so that great convenience is brought to judgment of the dissolution end point.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Owner 上海合全医药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products