224results about "Digestive system" patented technology

The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.

The conjugate compositions and methods are useful to elicit/augment an immune response to a tumor or microbial infection or to reduce the severity of autoimmunity, chronic inflammation, allergy, asthma, periodontal disease, and transplant rejection.

A process is provided for preparing spiro-hydantoin compounds of the formula II

wherein Z is N or CR_4b; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A₂ is a linker, G′ is a linker; Q is a linker; and R₂, R_4a, R_4c, and R_h are defined in the specification. The process optionally includes the enantiomeric separation of intermediates to allow preparation of enantiomers of the spiro-hydantoin compounds of formula II. Substituted spiro-hydantoin compounds may be prepared from the spiro-hydantoin compounds of formula II. The spiro-hydantoin compound of formula II and the substituted spiro-hydantoin compounds are useful in the treatment of immune or inflammatory diseases. Also, provided are products made by the instant inventive process and crystalline forms (prepared by any process) of the substituted spiro-hydantoin compound, 5-[(5S, 9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-ylmethyl]-thiophene-3-carboxylic acid, including solvates and salts thereof, as well as methods of use thereof. Crystalline forms of certain intermediates are provided.

The present invention provides methods, compositions, and kits for the treatment of disorders associated with overactivation of FGFR3, such as achondroplasia; bone or cartilage disorders; or vascular smooth muscle disorders, or for the elongation of bone. In some embodiments, the present invention provides polypeptides having a natriuretic peptide fused to an Fc domain of an immunoglobulin. Such polypeptides can be administered to subjects, e.g., subcutaneously, to treat a disorder associated with overactivation of FGFR3, a bone or cartilage disorder, or a vascular smooth muscle disorder, or to elongate bone. The invention also features nucleic acid molecules encoding such polypeptides and the use of the nucleic acid molecules for treating disorders associated with overactivation of FGFR3, bone or cartilage disorders, or vascular smooth muscle disorders, or for elongating bone.

A health-care food in the form of soft-capsule, capsule, particle, tablet, or oral liquid for improving immunity and preventing and treating the injury of stomach mucosa is proportionally prepared from the oil of seabuckthorn fruit and the extract of propolis through mixing and shaping.

An osmotic laxative followed by a bowel movement, followed by a stimulant laxative produces safe and effective cleansing of the colon with a minimal volume of liquid remaining in the colon in preparation for visualizing the interior of the colon by virtual colonoscopy. Administering to a patient a reduced volume of a PEG in water solution followed by an oral stimulant laxative, such as bisacodyl, after a biologically determined interval, cleanses the colon in preparation for the virtual colonoscopy, without the profuse uncontrollable diarrhea that typically follows either ingestion of the large volume isotonic lavages, or smaller volume hypertonic lavages.

The present invention provides a compound of Formula (I) or pharmaceutical acceptable thereof, wherein ‘R’ is herein described. In addition, the invention relates to composition comprising effective therapeutic amount of compound of formula (I) and methods of using the compounds for treating or prevention disorder such as nonalcoholic fatty liver disease (NAFLD) including fatty liver (steatosis), nonalcoholic steatohepatitis (NASH), and cirrhosis (advanced scarring of the liver).

The invention discloses a production method of alcoholic drink, belonging to the technical field of a production process method of an alcoholic drink which has efficacies of disease treatment, disease prevention, health protection and the like. The method comprises the steps of taking purely natural traditional Chinese medicines, corn stigmas, sweet potato stems, wheat and corns, processing, mixing with a small amount of distiller's yeasts, fermenting at proper humidity and steaming to juice which not only is a drink containing alcohol and alcohol taste, but also is alcohol with very low alcoholic strength. The alcoholic drink can be drunk by anybody and has the efficacies of disease treatment, disease prevention and health protection.

The invention relates to a healthcare compound beverage having functions of dispelling the effects of alcohol, nourishing the stomach and protecting the liver. The compound beverage is prepared from aqueous extracts of seven traditional Chinese medicines and a small quantity of honey and vitamin C, and every 1000 parts of the beverage is prepared from the following materials in parts by weight: 10-25 parts of pachyrhizua angulatus, 5-35 parts of honey tree, 5-25 parts of flower of kudzuvine, 5-20 parts of smoked plum, 10-30 parts of fingered citron, 10-25 parts of rhizoma galangae, 5-30 parts of liquorice, 5-25 parts of honey, and 1-20 parts of vitamin C. The various components of the compound beverage are scientifically matched to achieve coordinate compatibility, the effects of dispelling the effects of alcohol, nourishing the stomach and protecting the liver of the Chinese herbal medicines of pachyrhizua angulatus, honey tree, flower of kudzuvine, smoked plum, fingered citron, rhizoma galangae and liquorice are fully exerted to prevent people from suffering from symptoms after drinking of headache, dizziness, local skin allergy and gastrointestinal discomfort and achieve the purposes of mixing liquor and dispelling the effects of alcohol.

The invention discloses a medicament for treating cattle/pig constipation, and a preparation method thereof. The medicament is prepared from rhubarb, immature bitter oranges, magnolia officinalis, fructus cannabis, bunge cherry seeds, mirabilite, figwort roots and radix rehmanniae according to a certain mixture ratio by weight. The medicament has the efficacy in clearing heat, releasing toxin, purging pathogenic fire, dispelling fire stasis in large intestines, promoting blood circulation, removing blood stasis, relieving constipation, invigorating gallbladder and eliminating abdominal distension/pain, has the advantages of short treatment course, remarkable therapeutic effects, low cost, high cure rate and no relapse, and is widely used for treating cattle/pig constipation.

The present invention is to provide an imidazolidinedione derivative and oxazolidinedione derivative represented by the following general Formula (I) having the chymase and/or tryptase inhibition activity [wherein R<1 >and R<2 >are the same or different, and denote a lower alkyl group or a phenyl group, or R<1 >and R<2 >are taken together to form a ring, R<3 >denotes an optionally substituted naphthyl group or heterocyclic group, A denotes oxygen or NR<4 >(R<4 >is hydrogen or optionally substituted lower alkyl group), or NB<2>R<5 >(R<5 >is aryl group, and B<2 >is carbonyl group or sulfonyl group), and B<1 >denotes a carbonyl group or a sulfonyl group], or a pharmaceutically acceptable salt thereof.

The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises both the polysaccharides levan and inulin.

The present invention is belladonna extract preparing process and belongs to the field of medicine technology. The belladonna extract preparing process includes the following steps: crushing belladonna herb; soaking in and percolating with 50-90 % concentration alcohol solution to obtain filtrate and decompression recovering alcohol to prepare extractum; water decocting the belladonna residue after alcohol extraction for 1-4 times, filtering, merging filtrate and concentrating to relative density of 1-1.4; merging the alcohol extracted extractum and the concentrated liquid; and further concentration to obtain the belladonna extract. Compared with available technology, the belladonna extract has 10-15 % raised atropine content and thus raised medicinal effect.

The present invention provides an oral care composition comprising: (a) a dipeptide of the formula Xaa1-Xaa2 or Xaa2-Xaa1; wherein Xaa1 is an amino acid with a polar uncharged side chain; and Xaa2 is selected from an amino acid with a hydrophobic side chain, an amino acid with a polar uncharged side chain, and proline; or (b) a dipeptide of the formula Xaa3-Xaa4 or Xaa4-Xaa3; wherein Xaa3 is an amino acid with a hydrophobic side chain; and Xaa4 is selected from an amino acid with a hydrophobic side chain and an amino acid with a charged side chain.

The invention discloses a nutrition wine for nourishing yin and invigorating the kidney. The nutrition wine is prepared by pretreating the raw materials of 10-30 parts of Chinese yam, 20-40 parts of chrysanthemum, 5-15 parts of cinnamon, 10-20 parts of rhizoma polygonati, 8-12 parts of oyster, 20-30 parts of mulberry, 5-15 parts of white granulated sugar, 5-10 parts of caulis spatholobi and 900-1,000 parts of 42-degree distillate spirit; mixing and dipping; adjusting sugar; settling; and filtering. The nutrition wine has the functions of nourishing yin and yang, activating and enriching blood and building and invigorating body, can recuperate the subhealth and common symptoms of a human body, balance bodily functions and improve immunity and can be taken for a long time and has no side effect on the human body.

A bifidobacteria colostrum-soluble soft capsule and a preparation method thereof. The invention relates to a bifidobacterium colon-soluble soft capsule and a preparation method thereof. The soft capsule includes two parts, a content and a rubber skin, and the shell of the soft capsule is processed to make it colon-soluble. The content of the soft capsule is a stable suspension prepared by mixing and stirring bifidobacterium freeze-dried powder, vegetable oil, suspending agent and wetting agent. In addition, the capsule shell has colonic solubility by impregnating the soft capsule with formaldehyde. The invention encapsulates the bifidobacterium freeze-dried powder soft capsule with vegetable oil as the carrier, has the effect of dissolving the colon, has good product stability, is convenient for transportation and storage, prolongs the shelf life, and jointly acts the bifidobacteria and vegetable oil on the colon , improve the disorder of intestinal flora, achieve the effect of laxative, and solve the pain caused by constipation. The invention is applied to the field of preparation of probiotics.

Compositions include vitamin C, water and a reducing sugar, result in increased stability of vitamin C. Further the addition of alcohol to aqueous vitamin C compositions increased the stability of vitamin C. Moreover, aqueous vitamin C compositions having surfactant included therein enhance the absorption of vitamin C into skin. Methods of using the stable vitamin C compositions are also described.

The invention provides a diarrhea-resisting enteral nutrition composition, and discloses a liquid enteral nutrition agent capable of reducing the occurrence rate of emesis. The enteral nutrition agentcontains one or more pectins with the esterification degree being 5-30 % and the viscosity-average molecular weight being 10000-150000, one or more probiotics, and one or more nutrition components, wherein the content of calcium ions in the enteral nutrition composition does not exceed 0.1PPM. With the enteral nutrition composition, the adverse reactions (such as diarrhea, abdominal distension and emesis), especially diarrhea of the gastrointestinal tract can be obviously reduced.

The invention relates to a Chinese medicinal composition for treating gastric ulcer. The Chinese medicinal composition is characterized by being prepared from the following raw materials in part by weight: 10 to 20 parts of virginia moonwort, 10 to 14 parts of seville orange flower, 4 to 6 parts of mottled ardisia stem bark, 4 to 6 parts of Tibet camtschaticum hoffm root, 3 to 5 parts of Chinese artichoke, 4 to 6 parts of yanhusuo, 10 to 14 parts of fineleaf schizonepeta herb, 20 to 30 parts of tangerine peel, 8 to 10 parts of Chinese angelica, 10 to 14 parts of Himalayan teasel root, 15 to 17 parts of India madder root, 10 to 50 parts of Chinese date, 50 to 60 parts of costusroot and 8 to 14 parts of liquoric root. The Chinese medicinal composition has the advantages of good curative effect, moderate taste, no bitter and astringent tastes, mild nature, easiness for administration, no toxic or side effect, short treatment course, high cure rate and relapse prevention after healing.

A method of preparation of a treated Spirulina compound includes the steps of rehydrating desiccated Spirulina, stressing the culture and freeze drying to a powder. The resultant compound has activity as an anti-viral compound and an anti-bacterial compound. It is capable of effecting repair of skin defects in mammals and acting as a preventative agent to skin defects.

The invention discloses a traditional Chinese medicine composition for treating gastrectasia. The traditional Chinese medicine composition is prepared from the following important raw materials in parts by weight: 20-35 parts of corydalis tuber, 18-25 parts of cyperus rotundus, 20-30 parts of bletilla striata, 15-25 parts of clove, 10-20 parts of fingered citron, 5-10 parts of semen raphani, 5-15 parts of dried tangerine or orange peel, 5-10 parts of amomun kravanh, 5-10 parts of guava and 5-10 parts of fried rice sprout. The traditional Chinese medicine composition disclosed by the invention can be used for effectively regulating the functions of the intestines and stomach and radically treating gastrectasia, and is good in drug effect, high in effect taking speed and free of side effects.