141results about "Analgesics" patented technology

Low viscosity biodegradable polymer solutions of a liquid biodegradable polymer and biocompatible solvent and methods of using the compositions to form a liquid polymer implant are provided.

The conjugate compositions and methods are useful to elicit/augment an immune response to a tumor or microbial infection or to reduce the severity of autoimmunity, chronic inflammation, allergy, asthma, periodontal disease, and transplant rejection.

A process is provided for preparing spiro-hydantoin compounds of the formula II

wherein Z is N or CR_4b; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A₂ is a linker, G′ is a linker; Q is a linker; and R₂, R_4a, R_4c, and R_h are defined in the specification. The process optionally includes the enantiomeric separation of intermediates to allow preparation of enantiomers of the spiro-hydantoin compounds of formula II. Substituted spiro-hydantoin compounds may be prepared from the spiro-hydantoin compounds of formula II. The spiro-hydantoin compound of formula II and the substituted spiro-hydantoin compounds are useful in the treatment of immune or inflammatory diseases. Also, provided are products made by the instant inventive process and crystalline forms (prepared by any process) of the substituted spiro-hydantoin compound, 5-[(5S, 9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-ylmethyl]-thiophene-3-carboxylic acid, including solvates and salts thereof, as well as methods of use thereof. Crystalline forms of certain intermediates are provided.

The present invention refers to the use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, which have important activities in increasing the gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-α levels and an exogenous source of nitric oxide. More particularly, the present invention describes the use of such phthalimide and/or sulphonamide derivatives for the treatment of sickle-cell disease. The invention also has as a novel characteristic the disclosure of new functionalized phthalimide derivatives designed from the prototypes thalidomide and hydroxyurea, and designed rationally through the strategy of molecular hybridization for the treatment of said diseases. The invention still discloses a new method for obtaining a specific sulphonamide derivative which can be used in the preparation of a drug for the treatment of diseases which require reducing the levels of the TNF-α factor and an exogenous source of nitric oxide.

The water solution of bee glue includes the following steps: mixing bee glue and 95 % concentration alcohol solution via stirring, adding to water at 50-100 deg.c to obtain mixed water solution of bee glue and alcohol with alcohol content of 20-60 %, cooling to room temperature, letting stand and filtering; recovering alcohol and filtering to obtain filtrate; repeated alcohol dissolving and filtering of the filter residue and deposited matter to obtain filtrate; merging filtrate, concentration at 80 deg.c or adding water to density of 1.01-1.04, cooling, filtering to obtain the water solution of bee glue. The alcohol dissolving and water extracting process is simple, and the water solution of bee glue has high flavone content, no organic solvent and additive, low preparation cost and good biological effect. The water solution of bee glue may be used in preparing products for lowering blood sugar, lowering blood fat, resisting inflammation and regulating immunity.

Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging., etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof.

Described herein are substituted 2-(azetidin-2-on-1-yl)alkanoic acids, alkanedioic acids and 2-hydroxyalkyl alkanoic acids, and 2-acyl alkanoic acids, and derivatives thereof, that are capable of modulating activity at the cannabinoid-1 (CB1) and/or cannabinoid-2 (CB2) receptor. Also described herein are methods for treating mammals in need of relief from disease states associated with and responsive to modulation of the CB1 and/or CB2 receptor activity.

The present invention is to provide an imidazolidinedione derivative and oxazolidinedione derivative represented by the following general Formula (I) having the chymase and/or tryptase inhibition activity [wherein R<1 >and R<2 >are the same or different, and denote a lower alkyl group or a phenyl group, or R<1 >and R<2 >are taken together to form a ring, R<3 >denotes an optionally substituted naphthyl group or heterocyclic group, A denotes oxygen or NR<4 >(R<4 >is hydrogen or optionally substituted lower alkyl group), or NB<2>R<5 >(R<5 >is aryl group, and B<2 >is carbonyl group or sulfonyl group), and B<1 >denotes a carbonyl group or a sulfonyl group], or a pharmaceutically acceptable salt thereof.

The invention discloses a traditional Chinese medicine combination used for treating rheumatic heart disease and pertains to the Chinese medicine field. The Chinese medicine preparation takes the following ingredients as the active ingredients: root of rehmannia, radix codonopsis pilosulae, red sage root, fourstamen stephania root, medical glue, radices polygonati officinalis, lilyturf root, cassia twig, fructus schizandrae, liquorice and wu chia pee. The traditional Chinese medicine combination used for treating rheumatic heart disease have the effects of benefiting vital energy, enriching the blood, enheartening the heart-yang, nourishing the heart, benefiting the pulse, promoting blood circulation by removing blood stasis and repairing an impaired heart valve.

The invention pertains to an aqueous composition containing lactoferrin, 35-70 wt % carbohydrate and/or polyol stabilizers, based on the total weight of the aqueous composition, said composition exhibiting a pH higher than 2, lower than 5. At these 5 conditions, the aqueous composition and lactoferrin contained therein may be subjected to a heat treatment without significantly affecting the physiological activity of the lactoferrin. The invention thus particularly pertains to the above aqueous composition, being heat-treated, thus containing heat-stabilized lactoferrin.

The invention belongs to the field of medicine and personal care, and particularly relates to propolis-aloe bacteriostatic gel and a preparation method thereof. The propolis-aloe bacteriostatic gel isprepared from the following raw materials in percentage by mass: 8-12% of golden cypress, 8-10% of fructus cnidii, 6-11% of stemona, 9-12% of fructus kochiae, 7-9% of divaricate saposhnikovia roots,4-8% of seaweeds, 3-6% of aloes, 0.5-0.8% of propolis, 1-1.4% of chlorhexidine acetate, 0.8-1.2% of carbomer 940, 0.08-0.11% of methylparaben, 0.09-0.12% of triethanolamine, 0.9-2.1% of ethanol and 36-40% of purified water. The propolis-aloe bacteriostatic gel is propolis-aloe gel prepared through the compound compatibility of the propolis and the aloes, through the synergistic effect of the propolis and the aloes, the effects of inhibiting the growth of bacteria, promoting wound healing, diminishing inflammation, realizing sterilization, realizing moistening and nourishing, replenishing water, removing acne, removing eczema and realizing spot-fading can be effectively achieved, and especially, the bacteriostatic effect on escherichia coli, staphylococcus aureus, hemolytic streptococcus and the like is achieved.

The invention relates to a traditional Chinese medicine medicament for internally and externally treating chronic prostatitis and discloses a traditional Chinese medicine medicament for internally and externally treating chronic prostatitis with composite syndrome types of dampness-heat diffusing downward and qi stagnation and blood stasis. The traditional Chinese medicine medicament is characterized by comprising the following medicinal material components in parts by weight: 15 to 25 parts of dahurian patrinia herb, 10 to 25 parts of dandelion, 10 to 20 parts of glabrous greenbrier rhizome, 10 to 20 parts of dianthus superbus, 6 to 10 parts of phellodendron amurense, 6 to 10 parts of angelica dahurica, 10 to 15 parts of red paeony roots, 6 to 10 parts of hiraute shiny bugleweed herbs, 10 to 15 parts of salvia miltiorrhiza, 6 to 10 parts of peach seeds, 6 to 10 parts of safflower, 6 to 10 parts of Szechwan chinaberry fruits, 6 to 12 parts of rhizoma corydalis, 6 to 10 parts of cowherb seeds, 10 to 15 parts of plantain seed (wrap-boiling) and 6 to 9 parts of licorice roots northwest origin.

The invention discloses a preparation method of high-purity gynostemma pentaphylla total saponin for veterinary drugs. The preparation method is characterized in that a medicinal gynostemma pentaphylla total saponin medicinal material is used as a raw material, and the high-purity target product, namely the gynostemma pentaphylla total saponin for the veterinary drug, is obtained by high-efficiency extraction and separation on the basis of combination of technologies such as continuous countercurrent supersonic wave extraction, ceramic membrane microfiltration and macroporous resin adsorption separation with a conventional solvent reflux extraction principle. The preparation method has the advantages that the product purity and the product yield are improved, the product quality and the high quality are stabilized, the production cost is reduced, the requirements on the development of the high-purity gynostemma pentaphylla total saponin for the veterinary drugs and highly-processed products of gynostemma pentaphylla total saponin are satisfied, the production process is in line with environmental protection requirements, and the difficulty in the coordination of working procedures such as extraction, solvent recovery, enrichment and purification occurring in the volume production process of the gynostemma pentaphylla total saponin for the veterinary drugs is solved through the continuous improvement of the technology and the adjustment of technological processes and technical parameters.

The present invention provides a rheumatism plaster, a thread-gluing breathable bag for packing rheumatism plaster and a production method thereof. The rheumatism plaster includes the following raw materials such as dried pinellia tuber, dried bile arisaema, dried szechuan aconite, dried kusezoff monkshood root, dried nux vomica, sesame oil and yellow lead. The rheumatism plaster is obtained through the following method: a required amount of sesame oil is boiled; then a required amount of dried pinellia tuber, dried bile arisaema, dried szechuan aconite, dried kusezoff monkshood root and dried nux vomica are mixed, poured into boiling sesame oil and fried with mild fire until the drug turns black and carbonized; herb residues are removed after fire is extinguished and a required amount of yellow lead is poured and evenly mixed after the sesame oil cools without boiling. The present invention adopts high-temperature sesame oil to make decoction of the five drugs, so that the toxicity disappears without decreasing the pharmacodynamical effect. The pharmacodynamical ingredients can be fully fried out; in addition, the quality of sesame oil is sticky, the sesame oil gradually dilutes in normal temperature of human body, the pharmacodynamical effect gradually releases and the plaster does not infiltrates the gauze and attach on the skin, so that the present invention achieves the aim of curing rheumatism without allergy. Besides, the present invention also has simple structure and convenient use.

Dispersing Qingkailing tablet as one pure Chinese medicine preparation has obvious curative effect on viral cold, acute tonsillitis, acute pharyngitis, acute bronchitis, high fever, etc. It has the functions of clearing away heat and toxic material and tranqilizing, and may be also used in treating high intracranial pressure disease, hydrocephalus, cerebral vascular dementia and other diseases. The medicine has high bioavailability, fast absorption and taking convenience. The present invention features that the dispersing Qingkailing tablet is prepared with eight kinds of Chinese medicinal materials, including cholic acid, baicalin, cape jasmine, isatis root, hyodeoxycholic acid, etc. as well as ten kinds of supplementary material, and through soaking, decoction, filtering, concentrating, deposition, crushing, drying, palletizing, finishing and other steps.

The invention provides a preparation method of capsules capable of activating blood and stopping pains. The preparation method comprises the following steps: taking six types of medicinal materials including 22g of Chinese angelica, 44g of radix notoginseng, 44g of vinegar processed frankincense, 11g of borneol, 111g of ground beetles and 67g of calcined pyrite; adding water with the weight which is 10 times as much as that of the medicinal materials; immersing for 0.5h and decocting for 1 hour; filtering and adding water with the weight which is 8 times as much as that of the medicinal materials into medicine residues; decocting for 1 hour and filtering medicine liquid; combining decocted liquid of the two times and concentrating until the relative density is 1.05 at 60 DEG C; adding ethanol until the volume percent of alcohol content reaches 75 percent; stirring, standing and filtering; concentrating filtrate until the relative density is 1.25 at 65 DEG C; recycling the ethanol to obtain a concentrated solution; carrying out super-critical extraction to obtain super-critical extract; continually concentrating and drying the concentrated solution; granulating and filling the capsules to obtain the capsules capable of activating blood and stopping pains. By adopting specific concentration and drying equipment, the prepared capsules capable of activating blood and stopping pains have high content of ferulic acid and can be applied to preparation of medicines for inhibiting Vero-E6 cell proliferation of African green monkey kidneys.