136results about "Metabolism disorder" patented technology

Dietary supplements and methods for management and control of body weight comprising at least one liver protecting agent and at least one mushroom in the form of powder, extract, or combinations thereof.

The conjugate compositions and methods are useful to elicit/augment an immune response to a tumor or microbial infection or to reduce the severity of autoimmunity, chronic inflammation, allergy, asthma, periodontal disease, and transplant rejection.

The invention relates to a method of treatment of resistance to platelet inhibitors, i.e. a method to overcome resistance of treatment with platelet inhibitors, said method comprising administering a therapeutically effective amount of dipyridamole in combination with a platelet inhibitor and, optionally, in combination with a third antithrombotic component such as direct thrombin inhibitors, factor Xa inhibitors, combined thrombin/factor Xa inhibitors, heparin, low molecular weight heparin, argatroban, bivalrudin, hirulog or polyglycans to a patient in need thereof. The invention further relates to the use of dipyridamole for the manufacture of a pharmaceutical composition for treatment of resistance to platelet inhibitors. The invention also relates to a method to diagnose resistance to treatment with platelet inhibitors, said method comprising measurement of the density of binding of Annexin V on platelets.

A process is provided for preparing spiro-hydantoin compounds of the formula II

wherein Z is N or CR_4b; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A₂ is a linker, G′ is a linker; Q is a linker; and R₂, R_4a, R_4c, and R_h are defined in the specification. The process optionally includes the enantiomeric separation of intermediates to allow preparation of enantiomers of the spiro-hydantoin compounds of formula II. Substituted spiro-hydantoin compounds may be prepared from the spiro-hydantoin compounds of formula II. The spiro-hydantoin compound of formula II and the substituted spiro-hydantoin compounds are useful in the treatment of immune or inflammatory diseases. Also, provided are products made by the instant inventive process and crystalline forms (prepared by any process) of the substituted spiro-hydantoin compound, 5-[(5S, 9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-ylmethyl]-thiophene-3-carboxylic acid, including solvates and salts thereof, as well as methods of use thereof. Crystalline forms of certain intermediates are provided.

The present invention provides methods, compositions, and kits for the treatment of disorders associated with overactivation of FGFR3, such as achondroplasia; bone or cartilage disorders; or vascular smooth muscle disorders, or for the elongation of bone. In some embodiments, the present invention provides polypeptides having a natriuretic peptide fused to an Fc domain of an immunoglobulin. Such polypeptides can be administered to subjects, e.g., subcutaneously, to treat a disorder associated with overactivation of FGFR3, a bone or cartilage disorder, or a vascular smooth muscle disorder, or to elongate bone. The invention also features nucleic acid molecules encoding such polypeptides and the use of the nucleic acid molecules for treating disorders associated with overactivation of FGFR3, bone or cartilage disorders, or vascular smooth muscle disorders, or for elongating bone.

A semi-recombinant method for the production of GLP-1 analogues and derivatives with non-proteogenic amino acids in the N-terminal part combining the use of recombinant expression techniques and chemical peptide synthesis.

The present invention relates to a method for processing human placental cell sample, a human placental cell sample obtained according to said method for processing human placental cell sample, a human placental cell bank, a method for banking human placental cells, a method for searching human placental cell sample in said human placental cell bank according to the present invention, a method for preparing human cord blood serum, use of human placental cells obtained by said method for processing human placental cell sample or human placental cell bank established by said method for banking human placental cells in treating human dysfunction and diseases due to cell injury or cell malfunction, as well as a method for treating human dysfunction and diseases due to cell injury or cell malfunction.

The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.

The present invention concerns an improved balance of the essential branched chain amino acids leucine, isoleucine and valine in infant formula.

A chewing spirulina tablet is prepared from spirulina and two or more of dextrin, microcrystalline cellulose, mannitol, xylitol, aspartame, glycyrrhizin, essence powder, superfine silica gel powder, and magnesium stearate through mixing, granulating by use of alcohol solution containing polyvitone K30, drying and die pressing.

The water solution of bee glue includes the following steps: mixing bee glue and 95 % concentration alcohol solution via stirring, adding to water at 50-100 deg.c to obtain mixed water solution of bee glue and alcohol with alcohol content of 20-60 %, cooling to room temperature, letting stand and filtering; recovering alcohol and filtering to obtain filtrate; repeated alcohol dissolving and filtering of the filter residue and deposited matter to obtain filtrate; merging filtrate, concentration at 80 deg.c or adding water to density of 1.01-1.04, cooling, filtering to obtain the water solution of bee glue. The alcohol dissolving and water extracting process is simple, and the water solution of bee glue has high flavone content, no organic solvent and additive, low preparation cost and good biological effect. The water solution of bee glue may be used in preparing products for lowering blood sugar, lowering blood fat, resisting inflammation and regulating immunity.

Described herein are substituted 2-(azetidin-2-on-1-yl)alkanoic acids, alkanedioic acids and 2-hydroxyalkyl alkanoic acids, and 2-acyl alkanoic acids, and derivatives thereof, that are capable of modulating activity at the cannabinoid-1 (CB1) and/or cannabinoid-2 (CB2) receptor. Also described herein are methods for treating mammals in need of relief from disease states associated with and responsive to modulation of the CB1 and/or CB2 receptor activity.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a chtiosnaoligosaccharide (COS) capsule and a preparation method thereof. The COS capsule comprises a content and a capsule shell. The content is mainly prepared from COS, microcrystalline cellulose, adhesive, calcium stearate, ethyl alcohol and superfine silica powder. The capsule shell is mainly prepared from hydroxypropyl starch, xanthan gum, a thickening agent, a plasticizer and water. The COS capsule is free from extraneous odor, and clean, tidy and smooth in appearance; both the weight deviation and the solubility of the COS capsule meet the related stipulations of Chinese pharmacopoeia. In addition, the capsule has good leakproofness and oxidation resistance, the problem that oxidation and moisture absorption can happen to COS easily is effectively solved, and long-term storage of the COS is facilitated.

The invention discloses a production method of alcoholic drink, belonging to the technical field of a production process method of an alcoholic drink which has efficacies of disease treatment, disease prevention, health protection and the like. The method comprises the steps of taking purely natural traditional Chinese medicines, corn stigmas, sweet potato stems, wheat and corns, processing, mixing with a small amount of distiller's yeasts, fermenting at proper humidity and steaming to juice which not only is a drink containing alcohol and alcohol taste, but also is alcohol with very low alcoholic strength. The alcoholic drink can be drunk by anybody and has the efficacies of disease treatment, disease prevention and health protection.

The present invention is to provide an imidazolidinedione derivative and oxazolidinedione derivative represented by the following general Formula (I) having the chymase and/or tryptase inhibition activity [wherein R<1 >and R<2 >are the same or different, and denote a lower alkyl group or a phenyl group, or R<1 >and R<2 >are taken together to form a ring, R<3 >denotes an optionally substituted naphthyl group or heterocyclic group, A denotes oxygen or NR<4 >(R<4 >is hydrogen or optionally substituted lower alkyl group), or NB<2>R<5 >(R<5 >is aryl group, and B<2 >is carbonyl group or sulfonyl group), and B<1 >denotes a carbonyl group or a sulfonyl group], or a pharmaceutically acceptable salt thereof.

A method for inhibiting dipeptidyl-peptidase IV is provided and includes administering a peptide to the dipeptidyl-peptidase IV, in which the peptide is isolated from a gelatin hydrolysate produced by enzymatic digestion with alcalase (ALA), bromelain (BRO), and flavourzyme (FLA).

The presently disclosed subject matter relates generally to the fields of molecular biology and medicine. More particularly, it concerns methods involving the use of GSK3 inhibitors in combination with radiation therapies. In some embodiments, administration of a GSK3 inhibitor to a subject results in an amelioration of cognitive decline, toxicity to vascular endothelial cells, and/or neuron death associated with radiation therapy alone.

Novel MCP-1 splice variant polypeptides and polynucleotides encoding same are provided. Also provided are pharmaceutical compositions comprising the splice variant polypeptides and polynucleotides, vectors and host cells comprising same. The compositions of the present invention are useful to treat various MCP-1 related disorders as well as for diagnosing, determining predisposition and/or prognosis of various disorders.

The invention relates to a novel sulphone acid derivative show in a formula (I), a preparation method thereof and application of a medicine composition containing the derivative in preparing medicines for treating diabetes and metabolic syndrome. The sulphone acid derivative has excellent in-vivo blood glucose decreasing activity, and can be used for preventing or treating diabetes. (The formula is shown in the description).

Compositions include vitamin C, water and a reducing sugar, result in increased stability of vitamin C. Further the addition of alcohol to aqueous vitamin C compositions increased the stability of vitamin C. Moreover, aqueous vitamin C compositions having surfactant included therein enhance the absorption of vitamin C into skin. Methods of using the stable vitamin C compositions are also described.

The invention provides medlar weight-reducing tea with function of soothing the liver to regulate qi, which is characterized by comprising 2-4 parts of hawthorn, 0.5-1.5 parts of green tangerine peel, 1-3 parts of cassia seeds, 0.5-1.5 parts of capillary wormwood herb, 1-3 parts of medlar and 0.5-1.5 parts of stellaria alsine by weight. The preparation method is characterized by comprising the following specific steps: 1. mixing the raw materials in proportion; 2. adding water to the mixture obtained in the step 1 and boiling the mixture for 30-50min, filtering the mixture and taking the filtrate; and 3. repeating the step 2 2-3 times, collecting the filtrate obtained every time to be concentrated and then carrying out spray drying to obtain tea powder. The tea has good weight-reducing effect and does not give rise to any adverse side effect.