Peptide for inhibiting dipeptidyl-peptidase iv

a technology of dipeptidyl-peptidase and inhibitory activity, which is applied in the direction of peptide/protein ingredients, extracellular fluid disorder, metabolic disorder, etc., can solve the problems of side effects and loss of insulinotropic activity

Inactive Publication Date: 2014-07-10
CHINA MEDICAL UNIVERSITY(TW)
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  • Summary
  • Abstract
  • Description
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Benefits of technology

The patent describes methods that can stop blood sugar from being absorbed by certain enzyme proteins called beta cells. These techniques involve giving these enzymes a specific chemical substance called alpha-pyroglutaminolysin (a compound containing 4 amino acids) before they are given them to animals. This treatment helps prevent damage caused by excessive insulin levels.

Problems solved by technology

This patent describes different ways to prevent excessive blood sugar caused by high levels of glucosamme-related substances called glucokines. These include both glucocorticoids and GLP-1 receptor agonists. One method involves giving these substances alone, but this can cause unwanted side effects like hypotension and weight gain. Another way involves combining them together with other agents like calcium channel blockers and beta-blockers to achieve better control over blood sugar levels.

Method used

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  • Peptide for inhibiting dipeptidyl-peptidase iv
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[0033]The following examples are described for those skilled in the art to further understand the present disclosure and should not be limited to the present disclosure.

Materials and Reagents

[0034]Atlantic salmon (Salmo salar) fish skins, processing byproducts recovered from fresh skin-off fillets, were supplied by Albion Fisheries Ltd. (Vancouver, BC, Canada). The fish skins were transferred on ice, vacuum packed, and stored at −25° C. until use. Three food-grade proteolytic enzymes were donated by Neova Technologies Inc. (Abbotsford, BC, Canada). Alcalase 2.4 L FG (from Bacillus licheniformis, 2.4 AU / g) and Flavourzyme 1000 L (from Aspergillus oryzae, 1000 LAPU / g) were products from Novo-zymes North America Inc. (Salem, N.C., Canada), whereas bromelain (from pineapple stem, 2000 GDU / g) was manufactured by Ultra Bio-Logics Inc. (Montreal, QC, Canada), Dipeptidyl-peptidase IV (D7052, from porcine kidney), Gly-Prop-nitroanilide hydrochloride, trichloroacetic acid (TCA), L-leucine,

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Abstract

A method for inhibiting dipeptidyl-peptidase IV is provided and includes administering a peptide to the dipeptidyl-peptidase IV, in which the peptide is isolated from a gelatin hydrolysate produced by enzymatic digestion with alcalase (ALA), bromelain (BRO), and flavourzyme (FLA).

Description

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Claims

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Application Information

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Owner CHINA MEDICAL UNIVERSITY(TW)
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