45 results about "Inflammation" patented technology

The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.

The conjugate compositions and methods are useful to elicit/augment an immune response to a tumor or microbial infection or to reduce the severity of autoimmunity, chronic inflammation, allergy, asthma, periodontal disease, and transplant rejection.

The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition preferably comprising chain extended, coupled or crosslinked polyester/poly(oxyalkylene) ABA triblocks or AB diblocks having favorable EO/LA ratios to a site in the body which has been subjected to trauma, e.g. by surgery, excision or inflammatory disease. In the present invention, the polymeric material provides a barrier to prevent or reduce the extent of adhesions forming.

The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.

The invention provides novel curcuminoid formulations which have improved aqueous solubility and bioavailability when compared to known curcuminoid dosage forms. Formulations of the invention exhibit an enhanced intestinal absorption of curcuminoids, a slower curcuminoid metabolism and a reduced rate of systemic curcuminoid elimination. Additionally, upon administration in vivo, the formulations described and claimed herein produce a high, sustained level of the curcuminoid metabolite tetrahydrocurcumin. For example, at about eight to about ten hours after oral administration to a human, tetrahydrocurcumin plasma levels of between about 50 ng/mL to about 175 ng/mL are detectable, even when that metabolite is absent from the administered formulation. Novel processes for making curcuminoid formulations which have improved aqueous solubility and oral bioavailability, and methods of treating a wide variety of inflammatory, immune and neurogenerative disorders and cancers, are also provided.

The invention relates to a traditional Chinese medicine compound pharmaceutical composition and a preparation method and application thereof. The traditional Chinese medicine compound pharmaceutical composition contains clove, Salvia miltiorrhiza, dodder, epimedium, fructus cnidii, radix codonopsitis, radix astragali, angelica, rhizoma ligustici wallichii, phellodendron, radix scutellariae, rhizoma coptidis, Gardenia, ebony, hawthorn and kaki calyx. The traditional Chinese medicine compound pharmaceutical composition has the efficacies of replenishing Qi to invigorate the spleen, warming uterus and tonifying Yang, tonifying kidney and consolidating, nourishing blood and tonifying Qi, activating blood flow and removing blood stasis and clearing heat and detoxicating and has the functions of preventing and curing the inflammations of the fallopian tubes of the laying fowls. The traditional Chinese medicine compound pharmaceutical composition has definite curative effect, rapid action, safe use and no toxic and side effects or residuals, meets the demand of safety of animal-derived foods, is easy to realize industrial production and does not have pollution on the environment. The invention also provides a preparation method of the traditional Chinese medicine compound pharmaceutical composition and the application of preventing and curing the inflammations of the fallopian tubes of the laying fowls and improving the laying function. The traditional Chinese medicine compound pharmaceutical composition can be a powder. The invention also provides a feed containing the traditional Chinese medicine compound pharmaceutical composition.

The invention discloses acne-removing liquid containing a tea tree flower extract. The acne-removing liquid comprises the following components in percentage by weight: 20.0-50.0 percent of tea tree flower extract, 0.2-5.0 percent of plant essential oil, 0.5-5.0 percent of a natural plant source antibacterial agent, 0.2-2.0 percent of salicylic acid, 0.2-2.0 percent of vitamin E and the balance of water. The acne-removing liquid disclosed by the invention realizes the purposes of efficient and multi-effect treatment of acnes on the premise of taking natural plant ingredients without toxic and side effects as raw materials at the most extent: 1) inhibiting excessive secretion of sebum, regulating the oil balance of skin, converging oily and acne skin and improving skin immunity; 2) inhibiting the reproduction of propionibacterium acnes and controlling pathogens; 3) controlling inflammation, preventing the destruction of a hair follicle sebaceous gland structure and reducing the acnes; 4) desalting and removing the acnes, and improving the moisturizing effect of the skin; 5) adopting an antibacterial agent and a preservative serving as natural plants to reduce skin allergy symptoms.

The invention discloses figwort root body wash. The figwort root body wash is prepared from, by weight, 1-10 parts of wood figwort root extract, 1-3 parts of artemisia vulgaris extract, 1-3 parts of sweet wormwood herb extract, 1-3 parts of fructus liquidambaris extract, 1-5 parts of sodium lauroamphoacetate, 1-10 parts of AES, 1-10 parts of lauryl sodium sulfate, 0.05-0.5 part of EDTA-2Na, 1-5 parts of glycine betaine, 1-3 parts of cocamidopropyl dimethylamine oxide, 1-5 parts of glycerin, 0.5-5 parts of sodium chloride, 0.1-1 part of citric acid, 0.1-1 part of figwort root essence and 100 parts of deionized water. The figwort root body wash has the effects of preventing and improving oily skins which are prone to inflammation and acne and beautifying skins.

The invention discloses a preparation method of a regenerated cellulose facial mask containing citrus essential oil and belongs to the technical field of cosmetics. The preparation method disclosed by the invention comprises the following steps: preparing a regenerated cellulose facial mask base material; preparing the citrus essential oil; preparing aqueous phase liquid; preparing oil phase liquid; preparing essence; and preparing the facial mask. The facial mask prepared by the preparation method disclosed by the invention has the advantages of high content of natural ingredients and easiness in absorption. The citrus essential oil prepared by the preparation method disclosed by the invention has the advantages of no additive and high purity. In addition, the citrus essential oil contains active ingredients which have biological activities such as inflammation resistance and oxidation resistance; and besides, the citrus essential oil has the efficacy of beauty and health care. Silk protein has the effect of repairing skin tissue cells.

Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and/or TRPV4 inhibitor. Further provided are compositions including a TRPA1 and/or TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application.

The invention provides an isodon amethystoides herbal tea drink and a preparation method thereof. The herbal tea drink is characterized by being prepared from the following traditional Chinese medicine materials in parts by weight: 15 to 20 parts of isodon amethystoides, 5 to 15 parts of oldenlandia diffusa, 10 to 15 parts of sculellaria barbata, 3 to 10 parts of polygonum cuspidatum, 3 to 10 parts of honeysuckle, 7 to 11 parts of salvia miltiorrhiza, 10 to 15 parts of astragalus membranaceus, 3 to 10 parts of tea leaves, 7 to 11 parts of radix bupleuri and 2 to 5 parts of Chinese dates. Based on the innovation of medicine selection, a formula, proportions and the preparation method, the functions of the isodon amethystoides for clearing away heat and toxic materials, resisting bacteria and diminishing inflammation, cooling blood and scattering stasis, harmonizing stomach and protecting liver, relieving cough and asthma, regulating immunity and the like are fully exerted while the defect of gastrointestinal discomfort caused by taking the isodon amethystoides for a long time is overcome at the same time, so that the herbal tea drink has various functions for preventing and treating throat diseases, respiratory tract diseases, digestive tract diseases, gastrointestinal diseases and other diseases, low immunity and the like which are caused by haze and environmental pollution.

The invention relates to a composition for an oral cavity and application and a preparation method of the composition. The composition comprises the following components in parts by weight: 0.1-1 partof a lemon extract, 0.1-2 parts of a propolis extract, 0.05-0.8 part of a tea leaf extract, 0.5-5 parts of sea salt, 0.1-5 parts of an Aloe vera extract, 0.05-0.8 part of melaleuca alternifolia essential oil, 0.06-1 part of a white birch bark extract and 0.02-1 part of a mangnolia officinalis bark extract. By selecting components, on the basis of medicinal principles of different components, withthe combination of the components of a specific ratio, and by virtue of sufficient synergetic effects of the components, the composition provided by the invention has efficient effects of inhibitingbacteria, eliminating helicobacter pylori, relieving gum inflammation and treating ozostomia; meanwhile, the composition provided by the invention is reasonable in cost, simple and convenient to prepare, safe to use, relatively good in universality and relatively applicable to commercial popularization.

The invention relates to a preparation method of a composite hemostasis material, and belongs to the technical field of composite materials. The composite hemostasis material is prepared from silver-supported seaweed fibers, sodium carboxymethylcellulose, chitosan and starch. The material has a good hemostatic effect and an antibacterial property, and above adopted raw materials are degradable materials, do not cause inflammations of wounds during use, and promote the growth of new tissues, the chitosan is crosslinked with the surface of erythrocytes to make erythrocytes adhered in order to form thrombus to stop bleeding, carboxymethyl cellulose has a good film forming property, and also has an adhesion preventing effect, the seaweed fibers which are a wound covering material have an excellent affinity, and can help to clot wound blood, absorb excessive secretions of the wound and keep the wound at a certain humidity in order to enhance the healing effect, and the seaweed fiber covering material allows oxygen to go through and bacteria to be blocked after in contact with a wound body fluid in order to promote the growth of the new tissues.

The invention discloses an external traditional Chinese medicine bag formula, a medicine bag and an application method thereof, and belongs to the field of traditional Chinese medicines. The externaltraditional Chinese medicine bag formula comprises the following components in parts by weight: 10-30 parts of dried ginger, 5-15 parts of mint, 10-20 parts of turmeric, 10-20 parts of radix angelicae, 5-15 parts of cassia twig, 2-10 parts of angelica sinensis, 2-10 parts of ligusticum wallichii, 2-10 parts of asarum and 50-90 parts of folium artemisiae argyi; and the traditional Chinese medicinebag prepared by using the formula has relatively strong effects of promoting blood circulation and removing blood stasis, diminishing inflammation and relieving pain, warming channels and dredging collaterals, dispelling cold and the like through synergistic interaction of all the components, the traditional Chinese medicine bag is used for promoting metabolism by virtue of hot compress for bloodcirculation, is relatively high in comfort degree and can be widely applied to the health care industry and treating for osteoarticular diseases such as cervical spondylosis and lumbar spondylosis anddeficiency-cold diseases, the traditional Chinese medicine bag is low in cost, convenient to use, high in safety, free of side effects, large in operation area, fast in effect, remarkable in curativeeffect and the like; the method is simple to operate, raw materials are easy to obtain, cost is low, and the external traditional Chinese medicine bag is suitable for market requirements in the traditional Chinese medicine and health-care industries.

The invention discloses an acne treatment gel with an acne treatment composition. The acne treatment gel consists of the following raw materials in parts by weight: 35-45 parts of a grease expelling mixture, 15-25 parts of nicotinamide, 1-10 parts of ACSD (coupled salicylic acid), 10-20 parts of a traditional Chinese medicine active mixture, 10-20 parts of mint alcohol lactate and 1-6 parts of dipotassium glycyrrhizinate. Epidermis micro-ecological conditions and pH values can be regulated, and most acne-resulted harmful florae are not easy to multiply or grow; sebaceous gland activity can be rapidly regulated, and water-oil balance of skin can be recovered; inflammation can be prevented and eliminated, and discomfort symptoms can be relieved.

The invention discloses an antibacterial whitening mouthwash and a preparation method thereof. The antibacterial whitening mouthwash comprises an antibacterial component and a mouthwash matrix component, wherein the antibacterial component comprises 0.05 to 0.5 part of lysozyme, 0.01 to 0.5 part of lauryl arginine ethyl ester hydrochloride, 0.01 to 1 part of dextran anhydrase and 1 to 10 parts ofabelmoschus manihot extract. A substrate component of the mouthwash comprises one or more of an emulsifier, a moisturize, a flavoring, an acid-base conditioner and an essence, and the balance is deionized water. Lysozyme and lauryl arginine ethyl ester hydrochloride are dissolved in a citric acid solution and uniformly stirred; the prepared ingredients are mixed with the emulsifier, moisturizer, flavoring and essence evenly, pH is adjusted, and abelmoschus manihot extract and dextran enzyme are added. The invention makes the synergistic effect between the natural antibacterial agent and the chemical antibacterial agent exist, and the mouthwash produced by the invention has high safety and good antibacterial activity, and can effectively prevent and control the occurrence of dental plaque and oral inflammation.

The invention belongs to the field of daily chemical products, particularly relates to bacteriostatic foot powder and a preparation method thereof, and provides bacteriostatic foot powder. The bacteriostatic foot powder comprises the following components in percentages by weight: alkannin 1-3%, cinnaldehydrum 2-4%, berberine 1-5%, patchouli alcohol 2-4%, menthol 1-2%, alkyl glycoside 2-6%, tea saponin 0.5-1.5%, dipotassium glycyrrhizinate 1-3%, a deodorant 2-10%, ethanol 5-25% and corn flour 36.5-82.5%. The bacteriostatic foot powder not only can effectively improve foot hyperhidrosis and prevent and treat foot odour, but also can inhibit bacteria, diminish inflammation and resist allergy, and effectively treats tinea pedis. Meanwhile, the provided bacteriostatic foot powder is gentle in property, and is safe and non-irritant.

The invention discloses a lung caring pill, belonging to traditional Chinese medicine preparations. The lung caring pill comprises the following active pharmaceutical ingredients in certain parts by weight: bulbus fritilariae, almond, pseudo-ginseng, lumbricus amd ephedra. The lung caring pill is used for treating bronchitis and chronic bronchitis, and the effective rate for preventing pulmonary fibrosis is up to 91.2%; and the toxicity test and clinical practice prove that the medicine is safe and effective and has no toxic or side effect. The medicine can have the effects of moistening the lung, resolving the phlegm, promoting the dispersing function of the lung, regulating the flow of qi and relieving cough and asthma. The lung caring pill does not have a therapeutic action on the formed fibrosis pathological changes, but can reinforce the blood flow of the partial capillary network, improve the pulmonary alveolus function, promote the extinction of the bronchus chronic inflammation, decrease the inflammatory exudation and prevent pulmonary fibrosis from further development. The lung caring pill has the characteristics of definite curative effect, high safety and high economical performance.

The invention provides a composition for skin allergy and impaired skin barrier and a preparation method thereof. The composition comprises the following components by weight percent: 8-12% of purslane extract, 3-7% of gentina root extract, 3-7% of sophora root extract, 3-7% of snowparsley extract, 3-7% of asiaticoside, 1-5% of densefruit pittany root-bark extract, 0.5-1.5% of artesunate, 1-3% oflicorice extract, 0.5-1.5% of ceramide, 0.3-0.9% of cholesterol, 0.2-0.6% of fatty acid, 15-27% of butanediol and 35-47% of deionized water. The composition disclosed by the invention mainly adopts traditional Chinese medicine components, is safe and effective, and has the effects of calming and relieving itching, relieving heat and diminishing inflammation and reducing swelling and removing dampness for facial allergy, hormone dependent dermatitis, acne rosacea and the like; and meanwhile, due to long-term use, the composition can achieve the effects of gradually improving erythema and desquamation, promoting keratinized cell differentiation maturation and repairing skin barrier to stabilize.

The invention relates to a traditional Chinese medicine preparation for treating prostatitis, which is characterized in that its active ingredients are made of the following traditional Chinese medicine raw materials: talc, Kuolou, Shiwei, white peony, plantago seed, scutellaria baicalensis and buliuxing , mallow seed, Tongcao, Angelica, licorice, Cistanche, Alisma, Haijinsha, Gansui, this medicine is easy to take directly, the course of treatment is short, the price is cheap, and it also has the function of regulating liver and kidney, improving immunity, and can quickly eliminate The inflammation and carrion in the prostate can achieve the advantages and effects of complete healing.

The invention discloses application of hydroxysafflor yellow A in preparing medicines for treatment or assistant treatment of obesity diseases. The invention discloses novel application of the hydroxysafflor yellow A in preparing the medicines for treatment or assistant treatment of the obesity diseases for the first time. Experiments prove that the hydroxysafflor yellow A can remarkably reduce body weight, reduce fat accumulation, improve insulin resistance, restore the glucose steady state, reduce inflammation, increase short-chain fatty acid generation and enhance intestinal barrier integrity. It is found that the hydroxysafflor yellow A can remarkably relieve the obesity diseases, no obvious adverse reaction is found, and the safety is good. The hydroxysafflor yellow A has the value ofbeing popularized into the effective medicines for treating obesity, a new choice is provided for treatment of obesity, and the current situation that safe and effective medicines for prevention andtreatment of obesity are lacked is relieved.

The invention discloses a compound clobetasol propionate nano-medicament of which the particle size is 1-100 nanometers. The medicament consists of the following components in percentage by weight: 10.0-50 percent of surfactant, 0-8 percent of cosurfactant, 0.5-20 percent of oil, 0.001-4.0 percent of amitraz, 0.001-4.0 percent of clobetasol propionate, 0.001-10 percent of terbinafine and the balance of distilled water, wherein the total percentage by weight of the components is 100 percent. The medicament has the effects of resisting bacteria, diminishing inflammation, relieving itching and pain, killing mites and treating fungal diseases, eczema and various types of dermatitis caused by fungi such as dermatophyte, microsporosis capitis, acrothesium floccosum, microzyme of monilia and chaff ringworm fungus, and the like. The medicament is a yellow or colorless clear transparent liquid and has the advantages of high stability, high wetting property, good transdermal effect, nontoxicity, non-irritation, high safety, easiness for preparing, low cost and convenience for popularizing.

The invention discloses a traditional Chinese medicine composition for treating cervical erosion. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-15 parts of fallopia japonica, 10-15 parts of cyrtomium fortunei, 5-10 parts of groundsel, 15-20 parts of sophora flavescens, 12-18 parts of Chinese pulsatilla root, 5-10 parts of frankincense, 8-14 parts of cuttlebone, 10-15 parts of aloe leaf, 6-12 parts of shaddock peel, 16-22 parts of gallnut, 5-10 parts of acacia catechu, 10-15 parts of plantain herb, 20-25 parts of mother chrysanthemum, 4-9 parts of fig leaf, 18-24 parts of lithospermum, 5-10 parts of calendula, 9-16 parts of rheum officinale, 12-18 parts of subprostrate sophora, 5-10 parts of nauclea officinalis leaf and 10-15 parts of houttuynia cordata. The traditional Chinese medicine composition has the effects of clearing away heat and drying dampness, inhibiting bacteria and killing bacteria, diminishing inflammation and stopping pain, promoting blood circulation to remove blood stasis and removing slough and promoting growth of tissue regeneration, is obvious in curative effect, does not have a toxic or side effect, does not have an adverse reaction and symptoms, is high in cure rate, difficult to reoccur, safe and reliable and is worthy of promotion and popularization.

The invention discloses a qianxi capsule and a preparation method thereof. The capsule is composed of Andrographis paniculata Nees and senecio according to a certain proportion. The preparation method comprises taking a part of the Andrographis paniculata Nees, crushing into fine powder, and sieving; crushing the residual Andrographis paniculata Nees and the senecio into crude powder, percolating, processing the percolating liquid, collecting deposition, and spray drying; adding the above Andrographis paniculata Nees fine powder, starch and proper amount of gelatin, uniformly mixing, preparing into particles, drying and filling to obtain the finish product. The qianxi capsule is safe and effective, has efficacies of clearing away heat and detoxifying, diminishing inflammation and relieving pain and stopping diarrhea shown by pharmacological and clinical studies, and can be clinically used for treating enteritis, colitis, bacterial dysentery, nasosinusitis, etc.

The invention discloses a traditional Chinese medicine for treating reflux esophagitis. The traditional Chinese medicine is prepared from the following components in parts by weight: 10-16 parts of dangshen, 8-12 parts of cortex moutan, 8-12 parts of persimmon calyx, 6-10 parts of cassia twig, 4-6 parts of Pinellia ternate, 6-10 parts of costustoot, 5-8 parts of rhizoma atractylodis, 4-6 parts of spina gleditsiae, 6-10 parts of Mangnolia officinalis, 8-12 parts of immature tangerine and 4-8 parts of fresh ginger. The traditional Chinese medicine has effects of invigorating spleen-stomach and replenishing qi, dispersing blood stasis and promoting the circulation of qi, and diminishing inflammation, is obvious and stable in treatment effect for reflux esophagitis and is free from toxic and side effect.