64results about "Sexual disorder" patented technology

The present invention provides methods, compositions, and kits for the treatment of disorders associated with overactivation of FGFR3, such as achondroplasia; bone or cartilage disorders; or vascular smooth muscle disorders, or for the elongation of bone. In some embodiments, the present invention provides polypeptides having a natriuretic peptide fused to an Fc domain of an immunoglobulin. Such polypeptides can be administered to subjects, e.g., subcutaneously, to treat a disorder associated with overactivation of FGFR3, a bone or cartilage disorder, or a vascular smooth muscle disorder, or to elongate bone. The invention also features nucleic acid molecules encoding such polypeptides and the use of the nucleic acid molecules for treating disorders associated with overactivation of FGFR3, bone or cartilage disorders, or vascular smooth muscle disorders, or for elongating bone.

It is an object of the present invention to provide a solution for creating an effective method for retarding unhealthy manifestations brought by ageing of human beings (in particular, but not limited to the reduction of sexual activity and fertility, climax, changes in glucose tolerance, reduction of cognitive and mnestic functions, reduction of stress resistance, development of organ and tissue sclerosis) without directly affecting the genetic apparatus of the ageing cells.

According to the invention this task is solved by administration into the blood circulation of the agent which inactivates extracellular blood plasma DNA; the extracellular blood DNA inactivating agent can be embodied in the form of an extracellular blood plasma DNA destroying agent; said extracellular blood plasma DNA destroying agent can be embodied in the form of an DNase enzyme; the extracellular blood plasma DNA inactivating agent can also be embodied in the form of an extracellular blood plasma DNA binding agent; the extracellular blood plasma DNA binding agent can be embodied in the form of anti-DNA antibodies; the extracellular blood plasma DNA inactivating agent can be administered in the form of an enzyme modifying the chemical composition of extracellular blood plasma DNA; the extracellular blood plasma DNA inactivating agent can be embodied in the form of an agent that stimulates synthesis or activity of endogenous deoxyribonuclease, or an agent that stimulates the synthesis of antibodies which capable to bind extracellular blood plasma DNA.

The invention relates to a traditional Chinese medicine compound pharmaceutical composition and a preparation method and application thereof. The traditional Chinese medicine compound pharmaceutical composition contains clove, Salvia miltiorrhiza, dodder, epimedium, fructus cnidii, radix codonopsitis, radix astragali, angelica, rhizoma ligustici wallichii, phellodendron, radix scutellariae, rhizoma coptidis, Gardenia, ebony, hawthorn and kaki calyx. The traditional Chinese medicine compound pharmaceutical composition has the efficacies of replenishing Qi to invigorate the spleen, warming uterus and tonifying Yang, tonifying kidney and consolidating, nourishing blood and tonifying Qi, activating blood flow and removing blood stasis and clearing heat and detoxicating and has the functions of preventing and curing the inflammations of the fallopian tubes of the laying fowls. The traditional Chinese medicine compound pharmaceutical composition has definite curative effect, rapid action, safe use and no toxic and side effects or residuals, meets the demand of safety of animal-derived foods, is easy to realize industrial production and does not have pollution on the environment. The invention also provides a preparation method of the traditional Chinese medicine compound pharmaceutical composition and the application of preventing and curing the inflammations of the fallopian tubes of the laying fowls and improving the laying function. The traditional Chinese medicine compound pharmaceutical composition can be a powder. The invention also provides a feed containing the traditional Chinese medicine compound pharmaceutical composition.

The invention discloses compound ozone oil and a preparation method. The compound ozone oil is prepared from raw materials, namely 80-90 parts of camellia-seed oil, 10-30 parts of cnidium monnieri volatile oil and 5-15 parts of rhizoma atractylodis volatile oil, wherein the camellia-seed oil is subjected to ozone immobilization reaction, and the ozone oil of which the ozone content is 35-65g/L can be prepared. As the camellia-seed oil is adopted as base oil to prepare the ozone oil, and with the combination of the cnidium monnieri volatile oil and the rhizoma atractylodis volatile oil, the compound ozone oil is relatively wide in treatment field and relatively ideal in treatment effect. In addition, the compound ozone oil disclosed by the invention is scientific and reasonable in preparation process, and ozone can be stably immobilized without being volatilized and can be very well compounded with other traditional Chinese medicinal volatile oil, therefore, a synergic treatment function can be achieved.

The invention discloses a Chinese medicament for treating extrauterine pregnancy, which consists of the following raw material medicaments in part by weight: 4 to 6 parts of Chinese angelica, 2 to 4 parts of liquoric root, 2 to 4 parts of red paeony root, 2 to 4 parts of peach seed, 2 to 4 parts of cassia twig, 2 to 4 parts of tree peony bark, 2 to 4 parts of rhizoma corydalis, 2 to 4 parts of medicinal cyathula root, 2 to 4 parts of common burreed rhizome, 2 to 4 parts of zedoary, 2 to 4 parts of nutgrass galingale rhizome, 1 to 3 parts of cassia bark, 1 to 3 parts of cowherb seed, 3 to 5 parts of sappan wood, 1 to 3 parts of danshen root, 2 to 4 parts of dahurian patrinia herb, 2 to 4 parts of spreading hedyotis herb, 2 to 4 parts of Japanese milkwort herb and 1 to 3 parts of motherwort herb. The Chinese medicament for treating the extrauterine pregnancy has strong effects of killing embryos, and has obvious effects of decomposing and absorbing pelvic hematoma masses and blood. The Chinese medicament conservatively treats the extrauterine pregnancy, can maintain integrity of uterine tubes, does not damage tube walls, and can furthest improve fertility of patients.

The invention relates to a medicament for treating female climacteric metancholia. The component proportion of the preparation is as follows: aerial parts of epimedium 10g, Curculigo orchioides 10g, morinda officinalis 10g, phellodendron 10g, anemarrhena 10g, Chinese angelica 10g and ganoderma 10g. The accuracy of the ratio of the fixed dosages is plus or minus 10% of the above components. The medicament has the advantages of invigorating kidney qi and coordinating yin and yang. The above medicament has a safe and obvious effect on treating female climacteric metancholia and is free of any toxic or side effect.

The invention discloses a lung cancer and breast cancer treatment compound preparation containing active ingredients of traditional Chinese medicine and a preparation method of the lung cancer and breast cancer compound preparation. The lung cancer and breast cancer treatment compound preparation is made from erianin, taxol, bufalin and bruceine D according to a certain weight ratio. According to the preparation method, liposomes are prepared according to an ethyl alcohol injection method or dropping pills are prepared by taking polyethylene glycol as a base material to obtain the lung cancer and breast cancer treatment compound preparation containing the active ingredients of the traditional Chinese medicine. The form of the compound preparation is compound liposomes and compound dripping pills. According to animal in-vivo anticancer pharmacological experiments, the lung cancer and breast cancer treatment compound preparation containing the active ingredients of the traditional Chinese medicine has obvious inhibiting effect on growth of lung cancer and breast cancer and has higher anticancer activity than chemotherapeutic drug 5-fluorouracil.

The invention relates to a traditional Chinese medicine composition for treating infertility. The traditional Chinese medicine composition is characterized in that the traditional Chinese medicine composition is prepared from the following pharmaceutical raw materials in parts by weight: 10-20 parts of rhizoma curculiginis, 15-25 parts of fluorite, 6-12 parts of moor besom, 10-15 parts of rhizoma acori graminei and 6-12 parts of fructus cnidii. The invention also provides application of the traditional Chinese medicine composition to preparation of medicine for treating infertility. The traditional Chinese medicine composition disclosed by the invention is few in number of herbal medicine and rich in raw materials, the preparation technology is simple and environmentally friendly, and the traditional Chinese medicine composition has good application prospect in the treatment of sterility of ovulation disturbance. The composition and proportioning are screened and obtained through a plurality of experiments, different raw materials and proportioning thereof have obvious synergistic effect, and the composition has the advantage of good curative effect.

The present invention provides transgenic mice deficient in corticotropin releasing factor receptor 2 (CRFR2). Mice deficient for CRFR1 exhibit decreased anxiety-like behavior and a decreased stress response. In contrast, CRFR2 null mutant mice are hypersensitive to stress and display increased anxiety-like behavior. These mice are useful for the study of anxiety, depression, and the physiology of the HPA axis. CRFR2 null mutant mice also exhibit increased angiogenesis in all tissues examined. Thus, CRFR2 antagonists may be used to stimulate angiogenesis for the treatment of various conditions. In contrast, CRFR2 agonists may be used to inhibit angiogenesis. A combination of urocortin and bFGF was observed to stimulate rapid hair growth.

The invention relates to liquid oxygen in-situ forming gel and a preparation method and application thereof. The liquid oxygen in-situ forming gel comprises the following materials in percentage by weight: 10 to 40 percent of poloxamer, 0.001 to 1 percent of nano silver and 59 to 89.4 percent of solvent. The preparation method comprises the following steps of: adding water into the poloxamer, stirring uniformly, swelling and defoaming to obtain a medicinal base material, adding the nano silver into the base material and stirring uniformly. The liquid oxygen in-situ forming gel can be used for treating vaginitis, rhinitis, otitis and skin tinea diseases. The poloxamer is taken as a temperature sensitive material, and the in-situ forming gel can reside in a human body for more than 20h, so that a medicine taking frequency can be reduced, the compliance of a patient can be improved, a pharmacological treatment effect can be enhanced, and toxic and side effects can be lowered.

The invention relates to a processing method of rhizoma corydalis. The processing method comprises the following steps: weighting rhizoma corydalis, adding rice vinegar the weight of which is 40% of that of rhizoma corydalis, putting the mixture in a sealed container to soak for 1 hour, draining and reserving excessive rice vinegar for later use, then putting soaked rhizoma corydalis in a pressure cooker for cooking at a temperature of 120 DEG C and a pressure of 0.2MPa for 2 hours, taking out rhizoma corydalis, drying in a heated air circulation oven at a temperature of 60 DEG C for 5 hours, taking out dried rhizoma corydalis, adding the excessive rice vinegar reserved in the soaking step, putting the mixture the sealed container for covered moistening until the rice vinegar are absorbed completely, taking out rhizoma corydalis subjected to covered moistening until the rice vinegar are absorbed completely, and drying in the heated air circulation oven at a temperature of 60 DEG C for 5 hours, thus obtaining the processed product of rhizoma corydalis, wherein the product has good pain alleviating effect.

The invention discloses cassia twig and poria cocos pills and a preparation method thereof. The cassia twig and poria cocos pills are prepared from, by weight, 190-210 parts of cassia twigs, 190-210 parts of poria cocos, 190-210 parts of cortex moutan, 190-210 parts of radix paeoniae rubra and 190-210 parts of peach kernels. The cassia twig and poria cocos pills have the effects of promoting blood circulation to remove blood stasis and relieving and eliminating lumps and can be used for treating symptoms of blood stasis retention in uterus, gestation threatened abortion, endless metrostaxis, uterine fibroid, endometriosis, ovarian cyst, annexitis and chronic pelvic inflammation; meanwhile, the cassia twig and poria cocos pills have the advantages of being reasonable in cost, small in toxic and side effects, convenient to take and short in curative effect; the cassia twig and poria cocos pills can be produced in a batched mode, are wide in appropriate people and have extremely high popularization value.

Compounds having a structure of Structure I:

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R¹, R², R³, R⁴, R⁶, Y¹ and Y² are as defined herein, and wherein at least one of R³ or R⁴ is a straight-chain C₁-C₆ haloalkyl, are provided. Uses of such compounds for treatment of various indications, including prostate cancer, as well as methods of treatment involving such compounds are also provided.

The invention discloses a multi-element lycopene phosphatide compound and a preparation method thereof. The multi-element lycopene phosphatide compound is mainly prepared by natural multi-element lycopene and phosphatide, wherein the mass ratio of multi-element lycopene to phosphatide is 1:0.05-5. The multi-element lycopene phosphatide compound is safe and reliable, and can obviously increase the bioavailability of the multi-element lycopene.

The invention belongs to the technical field of a traditional Chinese medicine physical therapy product, and specifically relates to ointment of Chinese ink made from pine soot. The ointment of Chinese ink made from pine soot is prepared from the following raw materials in parts by weight: 40-80 parts of Chinese ink made from pine soot, 20-40 parts of propolis, 40-60 parts of beewax, 5-15 parts of borneolum syntheticum, 0.5-1.5 parts of moschus, 10-35 parts of olibanum, 10-20 parts of myrrha and 3-10 parts of nanometer ceramic heating powder. In addition, the invention also provides a preparation method for the ointment of Chinese ink made from pine soot. The ointment of Chinese ink made from pine soot is simple in preparation process, convenient to use and operate, capable of integrating functions of bee therapy, ink therapy and hot compress, and has a remarkable effect on dispelling body dampness and cold.

The invention discloses a composition for preventing pregnancy hypertension, hyperlipidemia and hyperglycemia, and further provides a functional drink comprising the composition and 15-25 parts by weight of a sweetening agent and a preparation method of the functional drink. The composition is prepared from the components in parts by weight: 0.0002-0.0005 part of a folic acid compound, 0.0003-0.0025 part of vitamin B6, 2-3 parts of fructus jujubae, 5-7.5 parts of rhizoma dioscoreae, 1-1.5 parts of rhizoma zingiberis recens and 1.6-2.5 parts of caulis bambusae in taeniam. Compared with the prior art, according to the composition and functional drink for preventing pregnancy hypertension, hyperlipidemia and hyperglycemia, the pregnancy adverse reactions can be effectively reduced, immunity of pregnant women is enhanced, the physical power of the pregnant women is improved, pregnancy hypertension, hyperlipidemia and hyperglycemia are effectively prevented, the pregnancy adverse reactionsare relieved, and habitus of the pregnant women is enhanced.

The invention discloses traditional Chinese medicine bath antibacterial liquid/granules for regulating the Yang-deficiency constitution and a preparation and using method. The traditional Chinese medicine bath antibacterial liquid/granules are prepared from, by weight, 5-35 parts of rhizoma cibotii, 5-35 parts of fructus litseae, 5-35 parts of fructus cnidii, 5-35 parts of cassia twig, 5-35 partsof perilla leaves and 5-50 parts of tremella fuciformis. The preparation method comprises the steps that the tremella fuciformis is smashed into superfine tremella fuciformis powder; the other medicine materials are mixed and decocted by adding water, and then filter liquor is collected; the superfine tremella fuciformis powder is added into the filter liquor to obtain a mixture, the mixture is decocted and then concentrated into thick liquid with the relative density of 1.05-1.25, and the thick liquid is filtered to obtain the traditional Chinese medicine bath antibacterial liquid; the traditional Chinese medicine bath antibacterial liquid is further prepared to obtain the antibacterial granules. The traditional Chinese medicine bath antibacterial liquid/granules can effectively regulatethe Yang-deficiency constitution, and therefore, the aims of building the body and preventing diseases are achieved.

The invention discloses a traditional Chinese medicine composition for treating cervical erosion. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-15 parts of fallopia japonica, 10-15 parts of cyrtomium fortunei, 5-10 parts of groundsel, 15-20 parts of sophora flavescens, 12-18 parts of Chinese pulsatilla root, 5-10 parts of frankincense, 8-14 parts of cuttlebone, 10-15 parts of aloe leaf, 6-12 parts of shaddock peel, 16-22 parts of gallnut, 5-10 parts of acacia catechu, 10-15 parts of plantain herb, 20-25 parts of mother chrysanthemum, 4-9 parts of fig leaf, 18-24 parts of lithospermum, 5-10 parts of calendula, 9-16 parts of rheum officinale, 12-18 parts of subprostrate sophora, 5-10 parts of nauclea officinalis leaf and 10-15 parts of houttuynia cordata. The traditional Chinese medicine composition has the effects of clearing away heat and drying dampness, inhibiting bacteria and killing bacteria, diminishing inflammation and stopping pain, promoting blood circulation to remove blood stasis and removing slough and promoting growth of tissue regeneration, is obvious in curative effect, does not have a toxic or side effect, does not have an adverse reaction and symptoms, is high in cure rate, difficult to reoccur, safe and reliable and is worthy of promotion and popularization.

The invention belongs to the technical field of traditional Chinese medicine and relates to a pharmaceutic preparation for treating recurrent spontaneous abortion caused by blocking antibody deficiency and a preparing method thereof.The pharmaceutic preparation is elaborately prepared by embelia parviflora, Ficus erecta Thumb.var.beecheyana, loranthus parasiticus, radix acanthopanacis senticosi, radix codonopsis, Calystegia hederacea Wall., semen cuscutae, fructus lycii, rhizoma cimicifugae and herba lycopi.The pharmaceutic preparation has the advantages that the medicinal materials are combined to achieve effects of tonifying the kidney and the spleen, benefiting qi and nourishing blood and preventing miscarriage, elimination exists in tonifying, tonifying exists in promotion, and the kidney is tonified allow yin and yang to be tonified, kidney qi to be strong and essential qi to be strong; the spleen is tonified to achieve powerful qi and blood metaplasia and allow the chong and ren channels to be full, the fetus qi to be strong and robust, and the fetus to be supported and nourished.

The invention discloses a traditional Chinese medicinal composition for improving irregular menstruation and a preparation method thereof. The traditional Chinese medicinal composition comprises the following components by the weight percentage: 1.2%-25% of salvia miltiorrhiza, 1.1%-20% of poria cocos, 1.2%-22% of angelica sinensis, 1%-30% of peach kernel, 1%-25% of folium sennae, 1%-25% of coix seeds, 1%-15% of galagal rhizome, 10%-30% of black-bone chicken, 5%-25% of donkey-hide gelatin, 1.1%-8% of vitamin C, 1.1%-8% of vitamin E, and 0.2-25% of auxiliary materials. With adopting of the traditional Chinese medicinal materials of pearls, black-bone chicken, donkey-hide gelatin, salvia miltiorrhiza, poria cocos, angelica sinensis, peach kernel, galagal rhizome, eucommia ulmoides, coix seeds and the like as main raw materials, and with compatibility and resultant action of various medicines, the human body internal functions can be conditioned and improved, obsessions of body weakness lassitude, deficiency cold syndrome and other symptoms are effectively improved, and especially, female irregular menstruation, dysmenorrhea and other symptoms are improved obviously.

The invention is in particular concerned with a food product comprising one or more fats or oils and a carotenoid compound. The products of the invention may be used in reducing elevated total cholesterol, triglycerides and inflammatory damage, as well as improving tissue microcirculation and tissue oxygenation.

The invention discloses traditional Chinese medicine pills for treating puerperal uterine subinvolution and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The active ingredients of the traditional Chinese medicine pills consist of the following raw materials: Chinese date, root of sandhill tylophora, Chinese yam, dried longan pulp, rehmannia root, heterophylly faalsestarwort root, root of silverweed cinquefoil, herb of bifurcate cinquefoil, stem of noble dendrobium, mulberry fruit, manyflower solomonseal rhizome, chinese granesbill, cowpea, lalang grass rhizome, rhizoma corydalis, medicinal cyathula root, giant knotweed rhizome, motherwort herb, red rice, diverse wormwood herb, India madder root, curcuma longa, licorice root and crocus sativus. The drug properties of the medicinal materials for preparing the traditional Chinese medicine pills disclosed by the invention supplement with one another, and the traditional Chinese medicine pills are applied according to indications, has the effects of reinforcing the spleen to replenish qi, reinforcing the kidney to control bleeding, nourishing yin to tonify blood, cooling blood to stop bleeding, promoting blood circulation to remove blood stasis, breaking blood to promote the circulation of qi and inducing menstruation to stop pain, is good in absorption effect and significant in curative effect, does not have toxic or side effects and clinical adverse reactions, and is clinically verified to have a relatively high curative rate for treating the puerperal uterine subinvolution.