497results about How to "Improve stability" patented technology

The present invention provides a nano-micellar preparation containing vinca alkaloids antitumor agent for intravenous injection, which cincludes a therapeutically effective amount of vinca alkaloids antitumor agent (vinblastine, vincristine, vindesine and vinorelbine), a phosphatide derivatized with polyethylene glycol, together with pharmaceutically acceptable adjuvants. The preparation is prepared by encapsulating the medicament with a nano-micelle to obtain the nano-micellar preparation containing vinca alkaloids antitumor agent for injection. The vinca alkaloids antitumor agent and the phosphatide derivatized with polyethylene glycol form a nano-micelle with a highly uniform particle size. In the micelle, the hydrophobic core of encapsulated medicament is surrounded by polyethylene glycol molecules to form a hydrophilic protective layer, so that the medicament is prevented from contacting with the enzymes and other protein molecules in blood and being recognized and phagocytozed by reticuloendothelial system in body, and the circulation time in vivo of the micelle is prolonged.

The present invention discloses compositions as well as methods of making and using said compositions, having improved stability which, when applied to a variety of substrates and cured, form transparent coatings which have abrasion resistant properties, a matched refractive index to that of the substrate, and which can be tailored to control the extent of tint absorption (vide infra). The compositions comprise an aqueous-organic solvent mixture containing a mixture of hydrolysis products and partial condensates of an epoxy-functional silane, a carboxylic acid functional compound selected from the group consisting of carboxylic acids, multifunctional carboxylic acids, anhydrides, and combinations thereof, a metal oxide composite colloid, and a disilane. The coating compositions may further include a mixture of hydrolysis products and partial condensates of one or more silane additives, a colloidal silica material, and a tetrafunctional silane.

The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor agonist to stimulate the removal of pathological extraneous fluid from the subretinal and retinal spaces and thereby reduce the accumulation of said fluid associated with retinal detachment and retinal edema. The P2Y receptor agonist can be administered with therapeutic and adjuvant agents commonly used to treat edematous retinal disorders. The pharmaceutical formulation useful in this invention comprises a P2Y receptor agonist with enhanced resistance to extracellular hydrolysis, such as dinucleoside polyphosphate compounds, or hydrolysis-resistant mononucleoside triphosphate salts. The present invention also provides P¹-(2′-deoxycytidine 5′-)P⁴-(uridine 5′-)tetraphosphate, tetra-(alkali metal) salts such as tetrasodium, tetralithium, tetrapotassium, and mixed (tetra-alkali metal) salts. The present further provides a pharmaceutical formulation comprising a P¹-(2′-deoxycytidine 5′-)P⁴-(uridine 5′-)tetraphosphate, tetra-(alkali metal) salt, in a pharmaceutically acceptable carrier.

The invention provides a movable canopy device for preventing a landfill area of a rigid landfill from being exposed to rain. The device comprises a water collecting tank, a sliding rail is fixedly connected to the outer surface of the upper end of the water collecting tank, a drainage pipe is arranged on the outer surface of one side of the water collecting tank, a sliding block is slidably connected to the interior of the sliding rail, the sliding rail and the sliding block are of a T-shaped structure and matched with each other, the outer surface of the upper end of the sliding block is fixedly connected with a supporting rod, and the outer surface of the upper end of the supporting rod is fixedly connected with a rain baffle. According to the device, rainwater can be shielded, hazardous waste materials in the landfill area can be prevented from being exposed to the rainwater, after one landfill grid is filled and sealed, the canopy can be moved to the position above the next to-be-buried hazardous waste grid, the manufacturing cost of the canopy is reduced, the benefit of an enterprise is improved, and when the canopy is used in snowy days or a large number of sundries are accumulated on the surface of the canopy used for a long time, accumulated snow and sundries on the surface of the canopy can be cleaned, and the service lifetime of the device is prolonged.

It has been found that pharmaceutical compositions comprising water insoluble drugs can be manufactured and formulated in a manner ensuring fast dissolution in gastric fluid. Advantageously, the manufacturing process provides a significantly improved stability, thus resulting in compositions that may have a longer shelf life than conventionally formulated and processed drugs.

A coolant control valve unit includes a valve housing. The valve housing includes a first coolant supply passage and a second coolant supply passage, a coolant chamber in which coolant supplied through the first and second supply passages gathers, a first distribution passage and a second distribution passage being distributed from the coolant chamber to coolant components, and a bypass passage bypassing the first distribution passage. The coolant control valve unit also includes first and second valves disposed to open and close the first distribution passage and the second supply passage, a thermostat of a temperature sensitive type installed at the bypass and operating by a coolant temperature, a valve operator controlling movement of the first and second valves, respectively, and a wall formed at one side of the thermostat and in which a cooling passage is formed such that the coolant flows from the coolant supply passage to the second distribution passage.

The Spread Spectrum integration coherent receiver of the invention employs a time division multiplexing correlator bank and thus obtained coherent channel evaluator as a core. The receiver can execute initial PN synchronization, RAKE diversity coherent combination, AFC and adjacent cell search and combination receipt, and soft handoff. Further, “part capture in parallel based on slide energy window” and “tracking loop based on energy window barycenter” are introduced into the receiver of the invention, thereby simplifying the structure of the RAKE receiver. The receiver is capable of overcoming multipath fading, ensuring the RAKE receipt performance.