17 results about "Bioavailability" patented technology

The invention discloses a preparation method of traditional Chinese medicinal submicron powder for animals. The method comprises the following steps: 1, cleaning ; 2, slicing: cutting crisp and frangible traditional Chinese medicines into thick slices or long segments, and cutting solid or high-toughness traditional Chinese medicines into slices or short segments; 3, medicinal material division: dividing the above sliced medicinal materials into high temperature resistant traditional Chinese medicinal materials and traditional Chinese medicinal materials not resistant to high temperatures; 4, drying; 5, preliminary crushing: crushing the dried high temperature resistant traditional Chinese medicinal materials by adopting a hammer type crusher, and crushing the traditional Chinese medicinal materials not resistant to high temperatures by adopting an air-cooled universal crusher; and 6, micronization: adding the preliminarily-crushed traditional Chinese medicinal material particles into an ultrasonic airflow crusher, and further crushing to prepare the traditional Chinese medicinal submicron powder for animals. The method is in favor of reserving the bioactive components of the traditional Chinese medicines, and the prepared submicron powder for animals has the characteristics of high mixing uniformity, use convenience, high bioavailability and good palatability; and the method has the advantages of simple operation, low energy consumption, low emission, and low production cost, and is more suitable for the large scale production.

The invention relates to a zinc oxide-based nano-drug composition, and a preparation method and an application thereof. The preparation method of the composition comprises the following steps: 1, mixing a sodium hydroxide and/or potassium hydroxide-alcohol solution and a zinc acetate-alcohol solution to obtain a zinc oxide colloid reaction solution; 2, taking the zinc acetate-alcohol solution, simultaneously or successively adding the zinc acetate-alcohol solution and the drug molecule-containing sodium hydroxide and/or potassium hydroxide-alcohol solution to the zinc oxide colloid reaction solution obtained in step 1; and 3, centrifuging a mixed solution obtained in step 2, removing the obtained supernatant, washing the obtained material, purifying the washed material, and drying the purified material to prepare the composition. Zinc oxide is compounded with the drug through directly using the self properties of zinc oxide and the drug, and no polymer is introduced, so the synthesis method is simple and effective. The prepared composition has good dispersibility, the hydrodynamic size is 40-90nm, and the composition has the characteristics of high bioavailability, low toxicity and degradability.

Dispersing Qingkailing tablet as one pure Chinese medicine preparation has obvious curative effect on viral cold, acute tonsillitis, acute pharyngitis, acute bronchitis, high fever, etc. It has the functions of clearing away heat and toxic material and tranqilizing, and may be also used in treating high intracranial pressure disease, hydrocephalus, cerebral vascular dementia and other diseases. The medicine has high bioavailability, fast absorption and taking convenience. The present invention features that the dispersing Qingkailing tablet is prepared with eight kinds of Chinese medicinal materials, including cholic acid, baicalin, cape jasmine, isatis root, hyodeoxycholic acid, etc. as well as ten kinds of supplementary material, and through soaking, decoction, filtering, concentrating, deposition, crushing, drying, palletizing, finishing and other steps.

A composition and method of increasing the bioavailability of curcumin is provided. A synergistic combination of excipient polymers provides increased bioavailability thereby increasing the plasma concentration of curcumin and its metabolite curcumin O-glucuronide. The curcumin pharmaceutical compositions are suitable for modifying DNA methylation and treating diseases such as cancer.

The invention provides a dihydroergotoxine methanesulfonate sustained release tablet. The dihydroergotoxine methanesulfonate sustained release tablet comprises the following components in parts by weight: 1%-1.5% of dihydroergotoxine methanesulfonate, 70%-90% of sustained release agent, 8%-28% of expanding agent and 0.5%-1% of lubricating agent, wherein in the product obtained according to the formula, the sustained release agent can form a gel in water, the expanding agent can expand rapidly in water to ensure that the tablet is finally expanded to 10-20 times of the size of an original tablet; the volume of the tablet produces buoyancy to enable the tablet to float on a gastric fluid; with slow dissolution of the gel, a main drug releases slowly in vivo to achieve the sustained release effect. Besides, the main drug can be dissolved and absorbed in medicine liquid to achieve good bioavailability. The invention also provides a preparation method of the dihydroergotoxine methanesulfonate sustained release tablet. The preparation method is simple in process and suitable for popularization.

The invention provides a composition for eyes and having improved drying protection and retention, and belongs to the field of pharmaceutical preparations. The composition includes cyclosporin, nano micelle in-situ gel, and hyaluronic acid or a pharmaceutically acceptable salt thereof; and the composition is in a liquid form at normal temperature or low temperature, is a hydrosol form when the temperature is more than 35 DEG C, and can still maintain complete under the shear stress caused by the eyelid blinking of patients. A preparation method includes providing first solute and second solute; and mixing the solute under a condition of taking water as a substrate so that the composition including gel dispersoid can be formed. The provided composition is high in bioavailability and small in effect on eye pain and irritation, cannot cause the blurring of vision, can improve the compliance of the patients and/or reduce side-effects, can enhance ocular surface health, and has antibacterial and antiseptic effects; and the preparation method can increase adhesiveness, enhance gelation temperature, prolong retention and effective acting time, rising encapsulation yield, avoid self-agglomeration phenomenon, and enhance antioxidant protection effects and stability performance.

The invention discloses a multi-element lycopene phosphatide compound and a preparation method thereof. The multi-element lycopene phosphatide compound is mainly prepared by natural multi-element lycopene and phosphatide, wherein the mass ratio of multi-element lycopene to phosphatide is 1:0.05-5. The multi-element lycopene phosphatide compound is safe and reliable, and can obviously increase the bioavailability of the multi-element lycopene.

The invention provides a clopidol controlled-release microparticle preparation and a preparation method thereof. The clopidol controlled-release microparticle preparation has a core-shell structure, a mineral carrier which adsorbs clopidol forms a system inner core, and calcium alginate gel forms a system outer shell. The clopidol controlled-release microparticle preparation can effectively avoid burst release of drug in stomach, so that irritation to the stomach by the drug is reduced, and adverse reaction of a gastrointestinal tract is reduced. Granularity of the preparation is 50-900 micrometers, so that the preparation is convenient for being uniformly mixed with feed and conducive to livestock and poultry absorption, and bioavailability of the drug is improved. The preparation method is simple, and the preparation is free of dust pollution and suitable for industrialized production.

The invention relates to novel calcium chelating peptide as well as a preparation method and an application thereof. According to the invention, an amino acid sequence of the calcium chelating peptideis YQEPVIAPKL. The calcium chelating peptide provided by the invention is safe and non-toxic, and has better physicochemical activity compared with a traditional calcium supplement, and the calcium chelating capability of the calcium chelating peptide reaches 28.4 mg/g; the collagen peptide can be supplemented while absorption and bioavailability of calcium in a human body are improved, absorption and transport of calcium in Caco-2 small intestinal epithelial cells can be promoted, and the collagen peptide can be used as a raw material for drug development and biological calcium supplement. According to the preparation method provided by the invention, the calcium chelating peptide is successfully obtained, fish product resources can be fully utilized, the operation is simple, and a new way is provided for high-valued utilization of tilapia bones.

The invention relates to an effervescent traditional Chinese medicine composition having intense heat-purging and detoxicating function and a preparation method thereof. The effervescent traditional Chinese medicine composition contains the following ingredients by weight percents: 10-30% of coptis root; 10-30% of rhubarb; 10-30% of radix scutellariae; 10-30% of gardenia; 5-40% of effervescing agent and 5-20% of lubricating agent. The effervescent traditional Chinese medicine composition has the advantages of scientific and reasonable formulation, convenient usage, low cost, no toxic and side effect as well as residual medicine, fast effectiveness and high bioavailability.

The invention relates to a traditional Chinese medicine composition for treating porcine encephalitis and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following ingredients in parts by weight: 10-20 parts of radix curcumae, 5-10 parts of semen platycladi, 10-20 parts of Herba Lophatheri, 5-10 parts of fructus forsythiae, 10-20 parts of Flos Chrysanthemi, 10-15 parts of cortex moutan, 10-15 parts of rhizoma acori graminei and 10-15 parts of rhizoma anemarrhenae. The traditional Chinese medicine composition for treating the porcine encephalitis has effects of antibiosis, anti-inflammation and intracranial pressure reduction, and small toxic and side effects, is free from medicine residue, has low possibility of medicine resistance, is easy to absorb, high in bioavailability and convenient to use, meets requirements of safe veterinary medicine and animal-origin food safety guarantee and is relatively ideal.

Methods and compositions for treating a condition involving gastrointestinal symptoms comprising administering to a patient in need of such treatment an effective amount of a P-glycoprotein substrate, wherein the P-glycoprotein substrate is a compound exhibiting an efflux inhibition ratio (EIR) of greater than or equal to 0.4, wherein the P-glycoprotein substrate is administered in a manner to minimize bioavailability.