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3 results about "Chemotherapeutic drugs" patented technology

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Chemotherapy drugs kill cancer cells or prevent them from growing and dividing. Chemotherapy drugs are also called anti-cancer drugs. Chemotherapy drugs can shrink or limit the size of cancerous tumors. They may also prevent cancer from spreading to other parts of the body. There are more than 80 anti-cancer drugs.

Heparin-modified adriamycin liposome preparation and preparation method thereof

InactiveCN103720658AEasy to prepareHeparin has good hydrophilicityPowder deliveryOrganic active ingredientsSide effectCholesterol

The invention relates to the field of medicinal preparations, and in particular relates to a heparin-modified adriamycin liposome (Hep-DOX-Lip) preparation. The preparation is characterized by consisting of 1 part of adriamycin, 1-4 parts of heparin, 5-30 parts of soybean lecithin, 0.5-4 parts of cholesterol and 0.5 part of a cationic material. The invention further discloses a preparation method of the heparin-modified adriamycin liposome preparation. The heparin-modified adriamycin liposome preparation has an effect similar to pegylation, and can remarkably enhance the stability of an adriamycin liposome, prolong the in-vivo half-life period of a medicament, and enhance the bioavailability of the medicament. Meanwhile, the heparin-modified adriamycin liposome preparation can remarkably lower the toxic and side effects of chemotherapeutic drugs and enhance the compliance of patients.

Owner:CHINA PHARM UNIV

Long-chain non-coding RNA PRALR, and expression plasmid and use thereof

ActiveCN110129318AUseful for researchSuppress drug resistanceOrganic active ingredientsGenetically modified cellsChemotherapeutic drugsNon-coding RNA

The invention relates to a long-chain non-coding RNA PRALR, and an expression plasmid and a use thereof. Starting from TCONS-00013523 sequence, a complete gene sequence is discovered by 5'-RACE and 3'-RACE technologies and is named as PRALR (paclitaxel resistance-associated lncRNA, paclitaxel resistance-associated long-chain non-coding RNA). Then, the PRALR expression plasmid and siRNA are constructed, and the PRALR is further confirmed to be a novel ovarian cancer drug resistance-associated lncRNA; the constructed PRALR expression plasmid can significantly increase the expression quantity ofthe PRALR, and the designed siRNA can significantly reverse drug resistance of paclitaxel-resistant ovarian carcinoma cells. A powerful tool is provided for study of the mechanism of paclitaxel resistance and other chemotherapeutic drug resistance, and a reference is provided for clinical development of drugs to reverse the drug resistance of tumor to paclitaxel.

Owner:JINSHAN HOSPITAL FUDAN UNIV

Lung cancer and breast cancer treatment compound preparation containing active ingredients of traditional Chinese medicine and preparation method of lung cancer and breast cancer compound preparation

InactiveCN105079005AGood inhibitory effectHigh anticancer activityEther/acetal active ingredientsRespiratory disorderPolyethylene glycolIn vivo

The invention discloses a lung cancer and breast cancer treatment compound preparation containing active ingredients of traditional Chinese medicine and a preparation method of the lung cancer and breast cancer compound preparation. The lung cancer and breast cancer treatment compound preparation is made from erianin, taxol, bufalin and bruceine D according to a certain weight ratio. According to the preparation method, liposomes are prepared according to an ethyl alcohol injection method or dropping pills are prepared by taking polyethylene glycol as a base material to obtain the lung cancer and breast cancer treatment compound preparation containing the active ingredients of the traditional Chinese medicine. The form of the compound preparation is compound liposomes and compound dripping pills. According to animal in-vivo anticancer pharmacological experiments, the lung cancer and breast cancer treatment compound preparation containing the active ingredients of the traditional Chinese medicine has obvious inhibiting effect on growth of lung cancer and breast cancer and has higher anticancer activity than chemotherapeutic drug 5-fluorouracil.

Lung cancer and breast cancer treatment compound preparation containing active ingredients of traditional Chinese medicine and preparation method of lung cancer and breast cancer compound preparation

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Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

3 results about "Chemotherapeutic drugs" patented technology

Heparin-modified adriamycin liposome preparation and preparation method thereof

Long-chain non-coding RNA PRALR, and expression plasmid and use thereof

Lung cancer and breast cancer treatment compound preparation containing active ingredients of traditional Chinese medicine and preparation method of lung cancer and breast cancer compound preparation

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