26 results about "Drug resistance" patented technology

The invention relates to a method of treatment of resistance to platelet inhibitors, i.e. a method to overcome resistance of treatment with platelet inhibitors, said method comprising administering a therapeutically effective amount of dipyridamole in combination with a platelet inhibitor and, optionally, in combination with a third antithrombotic component such as direct thrombin inhibitors, factor Xa inhibitors, combined thrombin/factor Xa inhibitors, heparin, low molecular weight heparin, argatroban, bivalrudin, hirulog or polyglycans to a patient in need thereof. The invention further relates to the use of dipyridamole for the manufacture of a pharmaceutical composition for treatment of resistance to platelet inhibitors. The invention also relates to a method to diagnose resistance to treatment with platelet inhibitors, said method comprising measurement of the density of binding of Annexin V on platelets.

The invention relates to a direct-sown rice field weed control method for delaying or preventing barnyard grass from developing resistance, which belongs to the technical field of plant protection. The method uses different weedicides in different years, different weedicides are used in the same year, and the different action sites of different weedicides are utilized to control weeds in rice fields. The design is reasonable and novel; the method can ensure that the effect of controlling weeds can reach more than 98 percent in a single year and that the effect of controlling weeds can reach more than 95 percent as well in one cycle or multiple cycles; and compared with the prior art, the method can enhance the effect of controlling barnyard grass by 30 percent to 50 percent and the effect of controlling other weeds by more than 10 percent and increase the rice yield by 15 percent to 30 percent.

The invention relates to a sterilizing composition containing effective and active components of Cyazofamid and Epoxiconazole. The sterilizing composition is characterized in that general addition agent and excipient are added to be made into wettable powders, water dispersible granules and suspending agent, wherein the weight percentage of the effective and active components of the Cyazofamid and the Epoxiconazole is 1-40:60-1. The invention has outstanding effect of preventing and curing downy mildew, late blight and leaf spot and has more obvious effect than single agents. The sterilizing composition can generate higher synergy, broadens anti-fungal spectrum and overcomes and retards the generation of disease drug resistance.

The invention provides application of terpene as an acantholyda posticalis attractant and the acantholyda posticalis attractant. One or more of R-(+)-alpha-pinene, S-(-)-alpha-pinene, S-(-)-beta-pinene, S-(+)-3-carene, S-(+)-limonene, S-(-)-limonene and myrcene is used as the acantholyda posticalis attractant. The mixed terpene attractant consists of the R-(+)-alpha-pinene, the S-(-)-alpha-pinene, the S-(-)-beta-pinene, the S-(+)-3-carene, the S-(+)-limonene, the S-(-)-limonene and the myrcene in a volume ratio of 10-60:5-45:3-30:10-60:2-15:0.3-3:2-15, and more preferably 30:15:10:30:5:1:5. The plant source attractant of a host volatile matter is used for attracting a large amount of acantholyda posticalis, so that the acantholyda posticalis are gathered and fixed by an adhesive paper board and then cleared and pests are controlled and killed; and the acantholyda posticalis attractant has the advantages of low cost, high efficiency, safety to people and livestock, capable of preventing medicament resistance of the pests and the like, and is an effective novel means of preventing and controlling the acantholyda posticalis and very suitable for the population monitoring and entrapment prevention and control of the acantholyda posticalis.

The invention provides a sterilization corrosion inhibitor for oil field water treatment system as well as a preparation method and application thereof. The sterilization corrosion inhibitor is prepared from 5wt%to 60wt% of dodecyl dimethyl benzyl ammonium halide, 0.5 wt% to 5wt% of sterilization synergist, 10wt% to 30wt% of surfactant, 3wt% to 10wt% of buffer and the balance of water. The sterilization corrosion inhibitor has high sterilization efficiency, has high bactericidal effects on sulfate reducing bacteria (SRB) and total general bacteria (TGB), has long drug effect duration, is hardto produce drug resistance, simple in production process and low in cost, and has a good corrosion inhibition effect on CO2 corrosion.

The invention relates to the use of polysaccharides of Grifola frondosa in preparing drugs for controlling viral diseases in pigs, particularly to the use for controlling porcine rotavirus enteritis, porcine epidemic diarrhea and porcine transmissible gastroenteritis. For use, polysaccharides of Grifola frondosa are injected intramuscularly at a dose of 1.0-50 mg/kg, twice daily or mixed uniformly with a premix feed at a weight percentage of 0.1-10%. The premix feed is commercially available and pigs are fed ad libitum. The invention has the advantages that: the invention provide a new natural medicine for controlling viral diseases in pigs and improving porcine immunity in clinic; the natural medicine has high safety, definite effectiveness and controllable quality; and the natural medicine has easily-accessible raw materials, no toxicity and side effect and no risk of inducing drug resistance.

The invention discloses lactobacillus plantarum capable of adjusting ampicillin induced intestinal flora disturbance and belongs to the technical field of food. The lactobacillus plantarum CGMCC12436disclosed by the invention is amplification cultured under assistance of skimmed milk, trehalose and saccharose; after being frozen and dried, the lactobacillus plantarum is prepared into a biologicalpreparation; a viable bacterial content of the lactobacillus plantarum CGMCC12436 in the preparation is larger than 109CFU/g. The lactobacillus plantarum CGMCC12436 disclosed by the invention has theadvantages of lower growth generation time, high survival rate in in-vitro simulated gastric fluid and intestinal juice, good adhesion on human HT-29 cells and relatively lower drug resistance in drug allergy testing. The biological preparation prepared from the lactobacillus plantarum has the advantages that ampicillin induced intestinal flora disturbance in a mouse body can be obviously recovered, intestinal functions can be improved and has good market application prospect.

The invention relates to sturgeon meat quality improving bait and a preparation method thereof. The bait is prepared from components including, by weight, 10-20 parts of field snail powder, 20-30 parts of fish powder, 10-20 parts of earthworm powder, 8-12 parts of selenium-enriched yeast autolyzed powder, 5-10 parts of rice bran peptide, 0.5-1 part of multi-vitamins, 8-12 parts o and an immunopotentiator; the immunopotentiator is prepared from traditional Chinese medicine raw materials including, by weight, 6-10 parts of common andrographis herb, 6-10 parts of fructus forsythiae, 6-10 parts of radix bupleuri, 6-10 parts of folium artemisiae argyi, 6-10 parts of codonopsis pilosula, 6-10 parts of astragalus membranaceus, 6-10 parts of honeysuckle, 6-10 parts of medlar, 6-10 parts of radix isatidis and 6-10 parts of houttuynia cordata. The sturgeon meat quality improving bait is reasonable in compatibility, balanced in nutrition, low in processing cost, good in tastiness and food calling, high in sturgeon utilization, few in metabolic waste, obviously high in immunity of sturgeons, free from drug residue and drug resistance, good in safety and capable of effectively improving the quality of the sturgeons.

The invention belongs to the technical field of livestock breeding, and particularly relates to an ecological pig breeding method which includes the steps: (1) breeding place selection; (2) breeding area building; (3) boar reproduction; (4) rotational grazing type stocking; (5) breeding management of pips; (6) disease control; (7) excrement circulating utilization. According to the method, breeding environments are improved, management efficiency of the pigs is improved, excrement circulating utilization is achieved, good breeding circulation is formed, and environmental pollution is reduced.The pigs are bred by auxiliary feed containing Chinese herbal medicine compositions and Chinese herbal medicine drinking water, addition of antibiotics is decreased in the breeding process of the pigs, and the incidence rate of common diseases and drug resistance for the antibiotics of the pigs is reduced, so that pork is safer and better in taste.

The invention discloses an insect-resistant fusion gene mCryAb-VIP3A for coding insecticidal protein and an expression vector and application thereof, and aims at solving the technical problem that the drug resistance trend of insects to an insecticidal preparation cannot be restrained. According to the invention, an insect-resistant gene and the insect-resistant fusion gene mCryAb-VIP3A are designed, the protein encoded by the insect-resistant fusion gene is also provided, and an expression vector constructed by the insect-resistant fusion gene and recombinant bacteria constructed by the expression vector are designed. The insect-resistant fusion gene is applied to preparation of insect-resistant plant cells. The protein encoded by the insect-resistant fusion gene is applied to preparation of an insect-resistant preparation. The insect-resistant fusion gene disclosed by the invention can be stably expressed in corn, so that the biotoxicity generated by singly transferring the originalVIP3A (a) gene into a plant is avoided, the gene silencing phenomenon existing in exogenous gene expression is overcome, more choices are provided for plant pest control, and a new method is providedfor restraining the drug resistance trend of insects to an insecticidal preparation.

The invention relates to the technical field of release films, in particular to a preparation method of a silicon-free PET release film. The silicon-free PET release film comprises a PET film, and ischaracterized in that release agents are coated on two sides of the PET film. The silicon-free PET release film prepared by the invention has very good toughness, drug resistance, heat resistance andhigh transparency, is very suitable for various processing and use, does not contain silicon, and has the characteristics of good anti-sticking effect, stable performance and good high-temperature resistance.

The invention belongs to the field of medicines, and particularly relates to a pharmaceutical composition for treating invasive infection of candida albicans echinocandin drug-resistant bacteria and an application of the pharmaceutical composition. The active components of the pharmaceutical composition are composed of caspofungin and a compound L-269289, and in a strain for inhibiting drug resistance of candida albicans echinocandin in vitro, the mass ratio of caspofungin to the compound L-269289 is 1: 3-1: 36; and for treating invasive infection of a candida albicans echinocandin drug-resistant strain on mice, and the mass ratio of caspofungin to the compound L-269289 is 1: 10. In-vitro experiments prove that the combined use of caspofungin and the compound L-269289 can effectively killthe candida albicans echinocandin drug-resistant bacteria, and is suitable for treating invasive infection of the candida albicans echinocandin drug-resistant bacteria on mice.

The invention provides a lactation-promoting additive for milk cows, relating to a feed additive for milk cows. The invention solves the problem that the current antibiotic feed additive has residual drugs, is easy to occur drug resistance and may result in teratogenesis, mutagenesis and carcinogenesis. The milk-promoting additive for milk cows is prepared from daidzein and dispersant. The milk cow milk-promoting additive is safe, non-toxic, and may effectively improve the milk secretion performance, thus increasing the economic benefit of culturists.

The invention discloses an avermectin.triazophos emulsifiable concentrate, which comprises the components of, by mass: 0.1% to 0.3% of avermectin, 18.7% to 20.9% of triazophos, 2% to 6% of calcium dodecylbenzene sulfonate, 4% to 8% of styryl phenol polyoxyethylene ether, and 65% to 75% of xylene. Effective components of the product provided by the invention are avermectin and triazophos. Avermectin, triazophos and filing materials are prepared into an avermectin.triazophos complex-formulated pesticide according to certain proportions. With the pesticide, drug resistance of the crops is delayed, pest controlling effect of the pesticide is improved, merits of various medicaments are represented, cost is reduced, labor is substantially saved, and economic benefits are improved.

The invention discloses a bioactive glass composite film as well as a preparation method and application thereof. The composite film is a thin flaky degradable composite material, and is prepared frombioactive glass powder by using hyaluronic acid and polymer lactic acid-polyglycolic acid as carriers through film forming. The preparation method concretely comprises the following steps of (1) polylactic acid-hydroxyacetic acid end position activation; (2) hyaluronic acid tail end amination synthesis; (3) hyaluronic acid-polylactic acid-hydroxyacetic acid copolymer carrier synthesis; (4) hyaluronic acid-polylactic acid-hydroxyacetic acid copolymer gel dispersion preparation; (5) hyaluronic acid-polylactic acid polymer-bioactive glass composite film preparation. The composite film slowly releases bioactive glass nanometer particles; good biocompatibility is achieved; the long-effect anti-inflammatory effects can be achieved; drug resistance cannot be generated; the periodontium growth ispromoted; the dentinal tubule is sealed; the goal of reducing dentine hypersensitivity after the periodontal surgery can be achieved.

The invention discloses a weeding composition containing clethodim and fluoroglycofen-ethyl, which comprises effective components clethodim and fluoroglycofen-ethyl and the balance of pesticide adjuvants. The mass ratio of the clethodim to the fluoroglycofen-ethyl is 1:5-5:1, and the clethodim and fluoroglycofen-ethyl account for 3-70 wt% of the weeding composition. The weeding composition can be prepared into dispersible oil suspending agent, suspending agent, wettable powder or water-dispersible granules according to application demands to prevent and eliminate annual weeds in soybean fields. The weeding composition has better preventing and eliminating effects on annual weed in soybean fields than the single clethodim or fluoroglycofen-ethyl, lowers the consumption of the pesticide, reduces the adverse effect of the pesticide on the ecological environment, and effectively solves the problem of drug resistance of weed.

The invention relates to a kit of a peripheral blood free-nucleotide miRNAs-based ultrasensitive detection device and a detection method of the kit. The kit comprises 1) a microarray detection pool; 2) an external magnetic field; 3) premixed reaction solutions A and 4) premixed reaction solutions B. During detection of multiple targets to be detected, the premixed reaction solutions A for respectively and correspondingly detecting the targets to be detected are configured in parallel and are respectively marked as a premixed reaction solution A1 and a premixed reaction solution A2. The kit iscombined with biomolecular diagnosis, nano-magnetic microsphere enrichment and biochip technologies to develop a novel technique capable of directly and accurately detecting peripheral blood miRNAs related to occurrence, development and drug resistance of a malignant tumor without amplification at high sensitivity and high flux. The kit has an important value in the aspects of noninvasive detection of medical tumors, personalized medicine application, survival after chemotherapy and the like.

The invention relates to the technical field of feeds, in particular to a cow feed for preventing and treating diarrhea. The cow feed consists of the following substances in parts by weight: 45-55 parts of corn flour, 45-55 parts of flour, 15-25 parts of glucose, 25-45 parts of soybean meal, 18-25 parts of germ meal, 1-3 parts of calcium carbonate, 5-8 parts of semen myristicae, 3-6 parts of lalang grass rhizomes, 7-12 parts of hairyvein agrimonia herbs, 15-25 parts of oat, 8-12 parts of bran, 8-12 parts of coconut oil cakes, 3-6 parts of amber, 8-12 parts of sugar residues, 5-12 parts of radix codonopsis, 3-5 parts of bighead atractylodes rhizomes, 8-12 parts of poria, 5-8 parts of cortex magnoliae officinalis, 8-12 parts of rhizoma corydalis, 3-8 parts of radix bupleuri, 8-12 parts of dried orange peel, 5-8 parts of radix puerariae, 5-12 parts of inula helenium, 8-12 parts of garlic, 9-15 parts of asiatic cornelian cherry fruits, 15-20 parts of Chinese yams, 5-8 parts of smoked plums, 5-10 parts of licorice roots, 5-8 parts of radix scrophulariae, 8-12 parts of geranium wilfordii, and 5-10 parts of halloysitum rubrum. According to the cow feed, provided by the invention, various traditional Chinese medicines and plants are added and mixed, so that the diarrhoea can be effectively prevented, and when being used for treating the diarrhoea, the feed has the advantages of taking effect quickly, and being true in treatment effects, few in side effects and low in drug residues of livestock products, drug resistance is not liable to cause, and safety of people and livestock is guaranteed.

The invention discloses cucumber exosome-like vesicles containing cucurbitacin B and capable of being used as anti-cancer drugs. Cucurbitacin B can be used for inhibiting proliferation of various cancer cells, but an extraction method of cucurbitacin B is complex and time-consuming. The method of separating the cucumber exosome-like vesicles to obtain cucurbitacin B has the advantages of easinessand quickness in operation and the like, and the lipid bilayer of the exosome-like vesicles is used as a natural protective film of cucurbitacin B, so that the stability of cucurbitacin B can be maintained for a long time. Moreover, through the principle of similarity and intermiscibility, the intake rate of cells to cucurbitacin B is also improved to a certain extent due to the existence of the lipid bilayer. When the cucumber exosome-like vesicles act on human alveolar basal epithelial cells (A549 cells) of adenocarcinoma, the maximum cell activity inhibition rate of the cucumber exosome-like vesicles is twice that of a cucurbitacin B standard substance, the dosage is lower, the toxicity to normal cells and the drug resistance to cancer cells can be reduced, and the cucumber exosome-likevesicles have good anti-cancer potential and industrialization prospect, and have an important significance in the clinical tumor treatment application.