Methods and compositions for treating gastrointestinal conditions

a technology for gastrointestinal conditions and compositions, applied in the field of gastrointestinal conditions, can solve the problems of poor intestinal permeability characteristics, incomplete bioavailability, poor candidate substrates for p-glycoprotein oral administration, etc., and achieve the effect of minimizing the systemic effect of the drug

Inactive Publication Date: 2009-03-05
AGI THERAPEUTICS RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes ways to make things easier by reducing the amount of medicine needed without affecting their ability to fight diseases effectively. It also helps with treatment locally within the body rather than just on its surface.

Problems solved by technology

This patent describes various technical problem addressed in the patent text relating to improving the delivery of drugs via the gastrointestinal tract. These challenges include poor solubility and low permeability of some compounds, which makes it difficult to deliver them effectively. Additionally, there is a desire to develop effective ways to modify their release properties without affecting their overall absorption and systemic distribution.

Method used

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  • Methods and compositions for treating gastrointestinal conditions
  • Methods and compositions for treating gastrointestinal conditions

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Embodiment Construction

[0018]Unless otherwise stated, a reference to a compound or component includes the compound or component by itself, as well as in combination with other compounds or components, such as mixtures of compounds.

[0019]As used herein, the singular forms “a,”“an,” and “the” include the plural reference unless the context clearly dictates otherwise.

[0020]Except where otherwise indicated, all numbers expressing quantities of ingredients, reaction conditions, and so forth used in the specification and claims are to be understood as being modified in all instances by the term “about.” Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations that may vary depending upon the desired properties sought to be obtained by the present invention. At the very least, and not to be considered as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter

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Abstract

Methods and compositions for treating a condition involving gastrointestinal symptoms comprising administering to a patient in need of such treatment an effective amount of a P-glycoprotein substrate, wherein the P-glycoprotein substrate is a compound exhibiting an efflux inhibition ratio (EIR) of greater than or equal to 0.4, wherein the P-glycoprotein substrate is administered in a manner to minimize bioavailability.

Description

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Claims

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Application Information

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Owner AGI THERAPEUTICS RES
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