Sarcopenia animal model establishing method
A technology of animal model and establishment method, which is applied in the medical field, can solve the problems that are not conducive to the early research objects of the diagnosis and treatment of sarcopenia syndrome, lack of indirect animal experimental models, etc., and achieve good reproducible results
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[0024] The present invention provides a method for establishing a sarcopenia animal model, and the experimental process and principle of the present invention are illustrated below in conjunction with specific examples:
[0025] a laboratory animal
[0026] 72 4-week-old C57BL / 6 male mice were purchased and raised in separate cages. They were given normal mouse feed, free access to food and water, light for 12 hours / day, temperature at 20-25°C, and humidity at 40-60%.
[0027] Two experimental treatments
[0028] From the age of 1 month, C57BL / 6 male mice were divided into pairs to measure body weight, body composition and muscle function (muscle mass, grip strength, endurance and muscle fiber cross-sectional area indicators) once a month. Then 3 mice were randomly selected, anesthetized by subperitoneal injection of 7% chloral hydrate solution (purchased from Beyuntian Biotechnology Research Institute), and the skeletal muscles of the lower limbs (anterior tibialis muscle
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