9 results about "Biocompatibility" patented technology

Provided herein is a biocompatible implant for meniscus tissue engineering. Particularly, the biocompatible implant comprises a multi-layered crescent-shaped silk fibroin scaffold, in which each layer comprises distinct pore size and/or pore orientation, e.g., to mimic native meniscus complex architecture. Accordingly, the biocompatible implant can be used for repairing any meniscal defect or promoting meniscal regeneration in a subject.

The invention discloses a preparation method of a mesoporous silica in situ doped acrylic resin bone cement composite for enhancing durable release capacity of medicines. The preparation method comprises the steps of firstly, mixing an amino silicon dioxide nanometer material with bone cement liquid to obtain a mixture, mixing the mixture with a bone cement solidifying agent, and in the process ofa polyreaction, performing in-situ introduction of the mesoporous silica nanometer material containing medicines; and uniformly mixing a mesoporous silica material with the liquid agent, and besides,enabling amino and carboxyl in bone cement acrylic resin to form electrostatic interaction to realize uniform and stable distribution in the bone cement, and achieve the purpose of durable and uniform release of the medicines. The prepared composite is high in operability, self spaces can be used for efficiently loading the medicines, and unique 2-8-nm mesoporous bore diameter is designed to enable the medicines distributed in the deep layer of the bone cement to be slowly released to the outside of the cement, so that durable and efficient release of the medicines is realized, besides, the characteristic and the function of the bone cement can be individually improved, and the biocompatibility and the anti-infection characteristic of the bone cement can be improved.

The invention provides a 3D-printed xanthan glue gel scaffold. The scaffold is prepared by the following steps: S1, dissolving xanthan gum in ultrapure water at normal temperature to prepare a xanthangum aqueous solution, adding methacrylic anhydride, performing full stirring, adjusting the pH value of a system to 8-10, continuing reaction for 3-5 hours, and dialyzing and freeze-drying the solution to obtain xanthan gum methacrylate; and S2, dissolving the xanthan gum methacrylate in sterile PBS solution containing a photoinitiator to prepare sol in a sterile environment, uniformly mixing thesol and cartilage cells, performing extrusion printing by using a 3D biological printer to form the scaffold, and irradiating the scaffold with ultraviolet light for cross-linking so as to obtain the3D-printed xanthan glue gel scaffold. The invention also provides a preparation method of the 3D-printed xanthan glue gel scaffold. According to the 3D-printed xanthan glue gel scaffold provided by the invention, the mechanical property is adjustable, the shape and the microstructure are controllable, the biocompatibility is good, and the scaffold can be compounded with cartilage cells.

The invention relates to a preparation method of a glowing nanometer fibre with the biocompatibility. The preparation method comprises the following steps of dissolving carbon nanometer particles in a solvent, adding a high molecular material under a stirring condition in the mass ratio of the high molecular material to the carbon nanometer particles being (0.5:1)-(1:2), and stirring for 1-3 hours so as to obtain a uniform spinning fluid ultimately; injecting a spinning liquid into a needle cylinder, regulating an electrostatic spinning technology, collecting a layer of uniform white fibres which are collected from a receiving aluminum foil; and putting the white fibres into a high-temperature pipe-shaped atmosphere furnace, inputting nitrogen, heating to 600-1000 DEG C, carrying out heat preservation for 1-5 hours, and finally cooling to the room temperature so as to obtain the glowing nanometer fibre containing the carbon nanometer particles. The obtained fibre has the good biocompatibility, meanwhile, the fibres have a glowing property, the glowing nanometer fibre is suitable for being used in a biomedical field, and the glowing nanometer fibre is particularly utilized as a bracket material and is convenient to anaphase observation. The preparation method provided by the invention is simple, the production cost is low, and the preparation method can further meet the production and application requirements.

The invention relates to the technical field of medical materials, and particularly discloses a photoresponse silicon dioxide material and a preparation method and application thereof.The photoresponse silicon dioxide material contains dendritic mesoporous silicon dioxide, and the surface of the dendritic mesoporous silicon dioxide is modified with a fluorinated silane coupling agent and grafted with carboxylated spiropyrane. The photoresponse silicon dioxide material has the characteristics of high biocompatibility, good stability, high drug loading capacity, high encapsulation efficiency, low toxic and side effects and the like, and can be used for delivering macromolecular drugs. The photoresponsive silicon dioxide material is converted between hydrophilicity and hydrophobicity under light control, so that the photoresponsive silicon dioxide material has a photoresponsive drug controlled release effect and is suitable for skin drug delivery.

The invention relates to a fresh-keeping method for small and medium-sized traditional Chinese medicinal materials. The method comprises the steps: preparing a fibroin solution with the concentration of 0.1%-10%; pretreating the traditional Chinese medicinal materials to be preserved; soaking the traditional Chinese medicinal materials in the fibroin solution, and enabling the surfaces of the traditional Chinese medicinal materials to be in full contact with the fibroin solution; taking out the traditional Chinese medicinal materials from the fibroin solution, and drying; and carrying out crosslinking treatment on the dried traditional Chinese medicinal materials coated with the uniform protein films on the surfaces. Therefore, the long-term fresh-keeping effect can be achieved, and meanwhile, the finally formed protein film for fresh keeping of the traditional Chinese medicinal materials has biocompatibility, biodegradability, antibacterial property and safety.

The invention relates to a functional slurry. The functional slurry comprises a carbon nano material, metal nanoparticles, carbonate particles and a matrix material, wherein the surface of the carbonnano material and the surface of the metal nanoparticles are connected with organic groups. The invention further relates to application based on the functional slurry, which comprises a functional layer prepared based on the functional slurry, a functional film and a preparation method thereof, a flexible pressure sensor based on the functional film and a preparation method thereof. The functional slurry provided by the invention has excellent dielectric properties, and the flexible pressure sensor has excellent flexibility, sensitivity, biocompatibility and relatively high electrical outputperformance.

The invention relates to the technical field of biomedical materials, in particular to a block copolymer, organic nano-particles and a preparation method and application of the block copolymer and the organic nano-particles. Preparation monomers of the block copolymer comprise a dopamine methacrylamide monomer and a sulfobetaine methacrylate monomer in a molar ratio of 1: (0.25-4). The organic nanoparticles formed by the block copolymer have low cytotoxicity, excellent biocompatibility, lubricating ability, anti-inflammatory efficacy and anti-aging effect.