48results about How to "Good biocompatibility" patented technology

The invention relates to the field of biological monitoring, and specifically relates to a secondary antibody probe for a sandwich immune reaction by using an amperometric immunosensor, wherein, the secondary antibody probe is composed of calf thymus DNA molecular chains and nanospheres adhering to the calf thymus DNA molecular chains, and the surfaces of the nanospheres are covered by enzyme labeled antibody proteins while magnetic nanometer particles, which are formed by depositing a layer of amorphous zirconia on the surfaces of nanometer ferriferrous oxide particles, are filled in the nanospheres. The secondary antibody probe provided in the invention is suitable for measurring concentration of antigens by a sandwich immune reaction employing an amperometric immunosensor, and has the advantages of wide linear range of detection and low detection limits.

The invention relates to a method for realizing intracellular telomerase activity detection based on a chiral self-assembled nano sensor and belongs to the technical field of material chemistry. The method is realized by the following steps: assembling and constructing a chiral big-small gold dimer sensor by a telomerase primer (TE primer) sequence, assembling and constructing a chiral big-small gold dimer sensor by a telomerase primer mismatch (TE mismatch) sequence, modifying cell-penetrating peptide on two big-small gold dimmers, changing chiral signals of the two big-small gold dimer sensors in cells along with time, realizing intracellular telomerase activity detection based on the chiral signals of the big-small gold dimmers, and establishing a standard curve. According to the invention, the method for detecting intracellular telomerase activity by virtue the chiral signals is provided, and a gold nanoparticle dimer with high chiral yield and good dispersibility in the cells is prepared.

The invention belongs to the technical field of cancer treatment materials, and particularly relates to a modified two-dimensional phosphorus for photothermal therapy and a preparation method thereof.After preparation of two-dimensional nano-phosphorus by an optimized liquid phase separation method, silicon dioxide is used to cover the surface of the two-dimensional nano-phosphorus. The silicon dioxide not only isolates the two-dimensional nano-phosphorus from oxygen and water, overcomes a defect that the two-dimensional phosphorus is easily oxidized and degraded when the two-dimensional phosphorus is exposed to air and water. At the same time, a material is embolized into a main blood supply vessel of a tumor tissue by an artery, 808 nm near-infrared light can be used to pass through thesilicon dioxide, a two-dimensional phosphorus nano-chip is excited, and heat is generated to kill cancer cells; compared with traditional materials, the modified two-dimensional phosphorus for photothermal therapy and the preparation method thereof not only greatly improve photothermal conversion efficiency, but also reduce near-infrared use, and reduce damage of photothermal treatment to normaltissues, the modified two-dimensional phosphorus as a photothermal material has good stability.

The invention provides a preparation method of a nano-enzyme antioxidant, and belongs to the technical field of biological chemistry and biological physics. The preparation method comprises the following steps: carrying out ultrasonic treatment on a lanthanide series metal nitrate water solution and a polyacrylic acid water solution respectively to obtain a lanthanide series metal nitrate ultrasonic solution and a polyacrylic acid ultrasonic solution, wherein the lanthanide series metal nitrate water solution is a cerous nitrate water solution and/or a gadolinium nitrate water solution; mixingthe polyacrylic acid ultrasonic solution with the lanthanide series metal nitrate ultrasonic solution to carry out a base reaction so as to obtain the nano-enzyme antioxidant. A lanthanide oxide anda hydroxide formed by a high molecular material of polyacrylic acid are coated, so that the biological compatibility is improved.

The invention discloses a self-supporting graphene wall electrode and a preparation method and application thereof. The self-supporting graphene wall electrode comprises a graphene wall microtube of a hollow structure and a tantalum wire, wherein one end of the tantalum wire is tightly inserted into the graphene wall microtube, and the other end of the tantalum wire penetrates out of the graphene wall microtube. The preparation method of the self-supporting graphene wall electrode comprises the following steps: taking methane as a carbon source, nitrogen as an auxiliary gas and a tantalum wire as a supporting body, applying alternating current to the supporting body, carrying out chemical vapor deposition, depositing outside the tantalum wire to form a graphene wall microtube, and withdrawing the tantalum wire in the graphene wall microtube so that one end of the tantalum wire is positioned in the graphene wall microtube and the other end is positioned outside the graphene wall microtube. A high-density electrode can be manufactured easily, and the function can be refined by collecting multi-channel electroencephalogram signals in a small scalp area.

The invention discloses a paramagnetic-upconversion luminous composite nanometer particle, preparation method and application thereof, wherein the preparation method comprises the following steps of: compounding the nanometer particle with paramagnetism or raw material for preparing the nanometer particle with paramagnetism and the nanometer particle with upconversion luminous performance or the raw material for preparing the nanometer particle with upconversion luminous performance via reaction so as to prepare the paramagnetic-upconversion luminous composite nanometer particle. The paramagnetic-upconversion luminous composite nanometer particle prepared by the method is a composite nanometer material with MRI (magnetic resonance imaging) radiography and upconversion luminous performance, wherein the paramagnetic nanometer particle component has T1 or T2 weighted MRI radiography, and can be used as a magnetic resonance imaging contrast agent and a light power treatment nanometer material.

The invention relates to a collagen-based cell scaffold with vascular regeneration promoting performance and a preparation method thereof. According to the method, firstly, oxidized starch containingcarboxyl is prepared by employing a wet oxidation method; subsequently, an amidation reaction between the carboxyl of the oxidized starch and amidogen of collagen is realized under the catalytic action of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide; and the collagen-based cell scaffold with a uniform and controllable microscopic porous structure, a good mechanical property and the vascular regeneration promoting property is prepared by regulating the carboxyl content of the oxidized starch. The microenvironment of the collagen-based cell scaffold prepared by the invention can promote adipose-derived stem cells gradually transformed from adherent growth to aggregate growth in the scaffold, thereby inducing the adipose-derived stem cells to regulate high expression of a vascular endothelial growth factor and a fibroblast growth factor, promoting vascular regeneration of a wound, and accelerating healing of a wound surface. The collagen-based cellscaffold provided by the invention has potential market application prospects in the field of biomedical materials.

The invention relates to a novel gel film capacitive sensor for measuring the full-mouth tooth occlusal force and a method thereof. Each of the upper and lower surfaces of the insulating medium is pasted with a layer of ionic gel serving as electrolyte, two kinds of materials are soft and transparent, ionic gel is pasted on several points to form several capacitors which can change along with the occlusal force, the capacitors are connected in parallel, a layer of insulating medium is pasted on the upper surfaces of the capacitors, and a layer of insulating medium is pasted on the lower surfaces of the capacitors, influence of external parasitic capacitors is avoided, buses are connected to an acquisition card , and the total capacitance value under the action of full-mouth tooth occlusal force can be obtained, and therefore the full-mouth tooth occlusal force can be measured; the capacitive sensor resultant force measuring device can obtain the full-mouth tooth occlusal force by means of a simple parallel circuit, but a piezoresistive resultant force measuring device only can measure a single circuit, and cannot measure the cumulative sum, by employing the novel gel material, the tooth occlusion case can be simulated as real as possible to obtain the full-mouth tooth occlusal force, and the novel gel material has good repeated measurement precision, and is low in cost and easy to process, and is disposable, clean and sanitary.

The invention discloses a synthesis method of spherical nano copper sulfide and application thereof in preparation of photo-thermal anti-cancer drugs. The method comprises the following steps: dissolving 0.0350 g of soluble copper salt into 100 mL of water; then adding 25 mL of an ethyl acetate solution of sulfide with a concentration being 1mmol/L; reacting the mixture for 12h at the constant temperature of 30-40 DEG C; and then sequentially performing centrifugation, washing, drying and grinding to obtain the spherical nano copper sulfide. The spherical nano copper sulfide prepared by the method can be used as an anti-cancer drug carrier for preparing photo-thermal anti-cancer drugs. The spherical nano copper sulfide prepared by the method has the advantages of good biocompatibility, lowtoxicity, few side reactions and the like, and the synthetic process of the spherical nano copper sulfide is green and environment-friendly, mild in reaction condition, relatively low in cost and suitable for large-scale industrial production.

The invention discloses a medical suture material and a preparation method. The medical suture material comprises components in parts by weight as follows: 110-140 parts of magnesium, 1-2 parts of zinc, 0.1-0.4 parts of aluminum, 3-5 parts of molybdenum, 2-2.5 parts of calcium, 0.1 parts of carbon, 4-6 parts of niobium, 0.5-1 part of iron, 1-2 parts of manganese, 0.5-1 part of germanium, 1-2 parts of zirconium and 0.05-0.1 parts of titanium. The medical suture material has very high strength and elongation at break, is easily degradable and has good corrosion resistance and biocompatibility.

The invention provides a biodegradable film and a preparation method thereof. The preparation method comprises the steps: adding a polylactic acid-glycolic acid copolymer solution into a polyoxazolinesolution according to the preset mass ratio, stirring evenly, so that a blended solution is obtained, defoaming the blended solution for 3-7 hours under the vacuum condition that the vacuum degree is0.05-0.1 MPa, so that gas in the blended solution overflows to obtain a defoamed solution, pouring the defoaming solution into a mold, drying at room temperature, evaporating an organic solvent in the defoaming solution to form a film, and then taking out the film from the mold,the film is immersed in distilled water, so that the organic solvent remaining in the film is replaced with the distilled water, and then drying the film, so that the biodegradable film is obtained, wherein the predetermined mass ratio of the polylactic acid-glycolic acid copolymer solution to the polyoxazoline solution is 19: 1-1: 3. The preparation method provided by the invention is simple in process, and the prepared biodegradable film has good hydrophilicity, toughness and degradability and is suitable for being applied to vascular materials.

The invention discloses a self-healing hydrogel based on multiple dynamic chemical bonds and a preparation method thereof. A self-healing hydrogel material based on multiple dynamic chemical bonds. The sugar, aldehydated nanocellulose, and hydrazidated poly-L-glutamic acid are prepared into solutions respectively, then mixed and stirred, and left to stand to obtain a hydrogel product with the structure shown in formula (I). The hydrogel of the invention has the advantages of self-healing property, antibacterial property and good biocompatibility, and has wide application value.

The invention belongs to the field of preparation of hydrogels, in particular to a preparation method of a silver nanowire/PBAT (poly(butyleneadipate-co-terephthalate)) nanometer fiber/polyvinyl alcohol composite conductive hydrogel, which solves the problems of long preparation cycle and low mechanical strength in the existing conductive polyvinyl alcohol composite hydrogel. The preparation method comprises the following steps of using glycerol-water binary mixed solvent to replace a single water solvent in the traditional hydrogel, and using silver nanowires and PBAT micro-nanometer fibers as reinforcing materials to prepare the polyvinyl alcohol composite hydrogel. The preparation method has the advantages that the preparation cycle of the polyvinyl alcohol conductive hydrogel is greatly shortened; the prepared polyvinyl alcohol composite conductive hydrogel has good mechanical property, good biocompatibility, biodegradability and the like.

The invention belongs to the field of polyurethane foaming, and particularly relates to a polylactic acid polyurethane material and a preparation method thereof. The polylactic acid polyurethane material is prepared from a component A and a component B. The component A comprises the following raw materials in parts by weight: 50-200 parts of polyether polyol 1, 50-200 parts of polyether polyol 2 and 10-100 parts of TDI, wherein the functionality of the polyether polyol 1 is 2, and the molecular weight of the polyether polyol 1 is 1000-12000; and the functionality of the polyether polyol 2 is 3, and the molecular weight of the polyether polyol 2 is 1000-12000. The component B comprises the following raw materials in parts by weight: 20-200 parts of polylactic acid, 20-200 parts of a chain extender and 10-50 parts of a silane coupling agent. The prepared polylactic acid polyurethane material is good in biocompatibility, friendly to environment, resistant to bacteria and biodegradable, and the preparation method is simple in process.

The invention discloses a preparation method of water phase CdTe/CdSe core-shell quantum dots for rapid fingerprint appearance, and belongs to the field of biomarkers. The method comprises the following steps: mixing a certain solubility of cadmium salt and a mercapto compound, adjusting pH to be 8-11 with NaOH to obtain a stable cadmium salt complex; dissolving Te powder and NaBH4 in deionized water, blowing with N2 to remove O2, heating in water bath at about 90 DEG C until no color to obtain a Te precursor; heating Se powder and a Na2SO3 water solution for reflux reaction until Se is completely reacted to obtain a Se precursor; adding the Te precursor into the cadmium salt complex under the N2 protection, heating for reflux to obtain CdTe quantum dots; adding a certain amount of the Se precursor to the CdTe quantum dots, heating for reflux to obtain the CdTe/CdSe core-shell quantum dots. The invention provides a simple and rapid preparation method of water soluble phase fluorescent core-shell quantum dots, and the preparation method has good biocompatibility, and can be used for appearance.

The invention discloses a three-dimensional carbon-based pressure sensor making method, and relates to the technical field of pressure sensors.The method comprises the steps that foam metal nickel is put into a chemical vapor deposition furnace, methane and hydrogen are introduced for a reaction, and graphene is obtained; foam metal nickel which obtains graphene in the first step is soaked in a mixed aqueous solution of ferric nitrate and hydrochloric acid, foam metal nickel is removed, and foamed graphene is obtained; foamed graphene is washed with water, and drying is conducted; carbon-based fibers are arranged on the top and bottom of foamed graphene respectively to serve as a flexible electrode material; polydimethylsiloxane is poured on foamed graphene and carbon-based fiber flexible electrodes, curing is conducted, and a pressure sensor device is obtained.The pressure sensor has good biocompatibility with a human body and can be closely attached to the skin of the human body to collect physiological signals quantificationally in real time.

The invention discloses a collagen/silk fibroin composite support and a manufacturing method and application thereof. The collagen/silk fibroin composite support comprises a collagen-based porous support body and fibroin non-woven fabric. The fibroin non-woven fabric is closely integrated in the collagen-based porous support body. The collagen-based porous support body is provided with an aperture structure of 30-500 [u]m. The fibroin non-woven fabric is provided with a good three-dimensional porous structure and has good permeability. The aperture ranges from 20 [u]m to 3,000 [u]m. The diameter of single bright silk is about 10 [u]m, and generally ranges from 8 [u]m to 12 [u]m. The collagen/silk fibroin composite support obtained through the manufacturing method is excellent in biocompatibility and mechanical performance and is provided with a non-woven fabric structure with certain biodegradability. Tissue engineering skin construction can be met well. Then, skin wound healing is accelerated, and healing quality is improved.