The invention provides a wound repair composition. A formula of the wound repair composition comprises the following components in percentage by weight: 10-50 percent of
chitosan mucilage, 10-50 percent of an extracting solution of a
staphylococcus aureus metabolic product and 0-80 percent of medicament auxiliary materials, wherein the
chitosan mucilage is a solution consisting of
chitosan and an
aqueous solution of an acid; the
volume concentration of the acid in the
aqueous solution of the acid is 0.8-1.2 percent; and the
mass concentration of the chitosan in the chitosan
mucilage is 1-3 percent. The invention further provides a preparation method of the wound repair composition and an application thereof as a medicament for treating
skin or mucosal injure. The wound repair composition provided by the invention has the advantages of capabilities of promoting
tissue repair, promoting
wound healing and promoting the growth of epidermal cells, good infection inhibiting effect, high
biocompatibility, realization of flat
healed wounds, freeness from adverse side reactions, relieving
in patient pain, convenience for
nursing and using, easiness for storing, and the like.