9 results about "Acylation" patented technology

The invention discloses a preparation method for dihydrosafrole. Piperidine and propionyl chloride are used as initial raw materials, and the preparation method comprises the following steps of: 1) acylation reaction of Friedel-crafts of the piperidine: reacting the piperidine and the propionyl chloride in a solvent I under the catalytic action of a lewis acid catalyst, adding iced water after finishing the reaction, standing, separating phases, washing an organic phase in the lower layer and distilling the solvent I to obtain piperonyl ethyl ketone; and 2) reduction reaction of Wolff-Kishner-Huang-min-lon of the piperonyl ethyl ketone: refluxing the piperonyl ethyl ketone and hydrazine hydrate solution at the mass concentration of 80 to 90 percent in a solvent II for hydrazone reaction, and adding polyethyleneglycol-400 and potassium hydroxide and performing hydrazone decomposing reaction to obtain the dihydrosafrole. The method for preparing the dihydrosafrole has the characteristics of high product yield rate, mild process condition, simple operation and the like.

The invention discloses formamide and isonitrile compounds serving as influenza A virus inhibitors and preparation and application thereof. The structural formulae of the formamide-isonitrile compounds serving as the influenza A virus inhibitors are shown as a formula I and a formula II described in the specification, wherein R is selected from alkyl, naphthenic group, aromatic group, heteroaromatics group, amino acid group and substitutive derivatives of all the groups; the substituent groups of the substitutive derivatives are alkyl, naphthenic group, aromatic group, heteroaromatics group and amino acid group. The formamide and isonitrile compounds are prepared from amine serving as a raw material by means of acylation, dehydration and the like. These formamide and isonitrile compounds and pharmaceutically-acceptable salts thereof can be used for preparing anti-influenza medicaments of which the activities are much higher than that of an existing anti-influenza medicament, namely, amantadine, and the drug tolerance generated by existing compounds can be overcome.

The invention discloses a method for high-efficiency extraction of pumpkin pigments. The method is characterized by comprising the following steps: (1) extraction of pumpkin solution; (2) flocculation clarification; (3) enzymolysis reaction; (4) filtering treatment; (5) acylation reaction; and (6) preparation of pigment of 40 color value. According to the method, chitosan is used as a flocculation clarification agent, the yield of the product can be relatively improved, and the production cost is reduced; polyethylene glycol is used as the auxiliary solvent, the problem of poor solubility of the red pigments of natural pumpkin is well solved; due to reasonable addition of tartaric acid and ferulic acid, the problem of the stability of the finished product of the red pigment of pumpkin is solved; the adoption of the ultrafiltration technology can meet the needs of large-scale actual production; based on the method, the utilization rate of the raw material is high, the red pigment of pumpkin prepared according to the method not only has high color ratio but also has better properties, purity, stability and solubility and high comprehensive performance price ratio.

The invention discloses a preparation method of indole-3-carboxylic acid. The preparation method is implemented by the following steps: (1) adding a catalyst into an organic solvent prepared from indole; (2) adding solid phosgene into an indole solution containing the catalyst, so as to generate acylation reaction; (3) carrying out basic hydrolysis on a product generated in the step (2) by virtueof an alkaline solution; (4) carrying out acidization on a product generated in the step (3) by virtue of inorganic acid; and (5) carrying out recrystallization on a product generated in the step (4),so as to obtain indole-3-carboxylic acid. The preparation method is simple and convenient in operation and high in product purity and yield and can meet chemical and medicine production requirements.

The invention provides a high-selectivity protection method of hydroxyl. The method comprises the following steps of: dissolving an organic compound containing two or more hydroxys into proper aprotic solvents; adding an acylation reagent which has the molar weight equal to that of the hydroxy requiring protection; adding anionic salt which is of catalytic amount and is low in price and easy to gain; and reacting for sufficient time at proper temperature, thus protecting one or two hydroxys in a two-hydroxy or multi-hydroxy compound along with high selectivity. The high-selectivity protection method of the hydroxyl has the characteristics of being environment-friendly, mid in reaction condition, simple and convenient in operation and high in yield, and the adopted agents are green, environment-friendly, low in price, easy to gain, high in efficiency, etc.

The invention relates to a sucralose continuous acylation reaction device and a sucralose continuous acylation reaction method, the method is characterized by comprising the following steps: (1) esterification liquid sequentially passes through a first-stage condenser and a second-stage condenser in an amount of 3-4m<3>/L, is condensed and then is fed into a first-stage mixing reactor, the temperature of the first-stage condenser is controlled to be -2-0 DEG C, and the temperature of the second-stage condenser is -4--2 DEG C; (2) acetic anhydride is pumped into the primary mixing reactor according to the amount of 0.2-0.4 m<3>/L, the temperature of the primary mixing reactor is controlled to be -4--2 DEG C and the pressure to be 0.15-0.2 Mpa, the materials are fed into a secondary mixing reactor according to the amount of 3-4m<3>/L after the mixing reaction, and the temperature of the secondary mixing reactor is controlled to be -2--1 DEG C and the pressure is 0.15-0.2 Mpa; and (3) thematerial discharged from the secondary mixing reactor is pumped into an esterification liquid tank according to an amount of 3-4m<3>/L, wherein the gas phase in the esterification liquid storage tankenters a gas phase header pipe through a pipeline. The method has the beneficial effects that the reaction process can be controlled in real time, the reaction process is stable, and the production period is short; and the content of sucralose 6-ethyl ester is increased from the original 160g/L to 170-175g/L.

The invention provides a method for preparing N-acetyl-L-tyrosine. The method comprises the following steps: carrying out acylation reaction on acetic anhydride and L-tyrosine under an alkaline condition to obtain acylation liquid; adjusting the pH value of the acylation solution to increase by using alkali liquor, carrying out heat preservation reaction, and then adjusting the pH value of the obtained reaction solution by using acid liquor to obtain a reaction solution containing N-acetyl-L-tyrosine; and carrying out purification treatment on the reaction liquid containing the N-acetyl-L-tyrosine. The N-acetyl-L-tyrosine prepared by the method has the advantages of high yield, low content of related substances, high optical purity and the like, and the method is low in energy consumption, low in production cost and suitable for large-scale production and application.

The invention relates to a synthesis method of 2-chloro-1-(2, 2-dimethyl-4H-benzo [1, 3] dioxin-6-yl) ethanone, the method comprises the following steps: (1) carrying out hydroxymethylation on methyl 4-hydroxybenzoate to obtain methyl 4-hydroxy-3-(hydroxymethyl) benzoate; (2) carrying out acetonylidene protection on ortho-dihydroxyl of the 4-hydroxy-3-(hydroxymethyl) methyl benzoate, so as to obtain 2, 2-dimethyl-4H-benzo [d] [1, 3] dioxin-6-carboxylic acid methyl ester; and (3) carrying out chloromethylation on the 2, 2-dimethyl-4H-benzo [d] [1, 3] dioxin-6-carboxylic acid methyl ester, so as to obtain the 2-chloro-1-(2, 2-dimethyl-4H-benzo [d] [1, 3] dioxin-6-yl) ethanone. The synthesis route does not involve a Friedel-Crafts acylation reaction, liquid bromine does not need to be used, the initial raw materials belong to bulk chemicals, the synthesis route is short, the synthesis route is safer and more environmentally friendly, and mass production of the 2-chloro-1-(2, 2-dimethyl-4H-benzo [1, 3] dioxin-6-yl) ethanone is easy to achieve.

The invention provides a synthesis method of a hydroxyl-substituted styrene compound and a synthesis method of a photoresist resin monomer. The synthesis method of the hydroxyl-substituted styrene compound comprises the following steps: a) reacting a compound in a formula I-1 with a Witting reagent to obtain a compound in a formula I-2. The synthesis method of the photoresist resin monomer comprises the following steps: a) acquiring a compound as shown in the formula I-2 by adopting the synthesis method of the hydroxyl-substituted styrene compound; and b) reacting the compound as shown in the formula I-2 with an acylation reagent to obtain the photoresist resin monomer with the structural formula as shown in a formula I-3. The synthesis method of the hydroxyl-substituted styrene compound and the synthesis method of the photoresist resin monomer are high in yield and high in purity.