Nano-enzyme antioxidant and preparation method thereof
A technology of antioxidants and nano-enzymes, which is applied in the directions of antitoxins, pharmaceutical formulations, and medical preparations with inactive ingredients, etc., can solve problems such as poor biocompatibility, achieve good biocompatibility, and increase the effect of biocompatibility.
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[0036] The present invention provides a preparation method of nano-enzyme antioxidant, including the following steps:
[0037] Ultrasound the lanthanide metal nitrate aqueous solution and the polyacrylic acid aqueous solution respectively to obtain the lanthanide metal nitrate ultrasonic solution and the polyacrylic acid ultrasonic solution; the lanthanide metal nitrate aqueous solution is an aqueous solution of cerium nitrate and / or an aqueous solution of gadolinium nitrate;
[0038] The polyacrylic acid ultrasonic solution and the lanthanide metal nitrate ultrasonic solution are mixed, adjusted to be alkaline, and the base reaction is performed to obtain the nano-enzyme antioxidant.
[0039] In the present invention, the lanthanide metal nitrate aqueous solution and the polyacrylic acid aqueous solution are respectively ultrasonicated to obtain the lanthanide metal nitrate ultrasonic solution and the polyacrylic acid ultrasonic solution; the lanthanide metal nitrate aqueous solution
Example Embodiment
[0065] Example 1
[0066] Take 2.17g Ce(NO 3 ) 3 ·6H 2 O, add 5mL of water, prepare a 1mol / L cerium nitrate solution, ultrasonic for 1h to obtain an ultrasonic solution of cerium nitrate; take 5g of polyacrylic acid (PAA) with a molecular weight of 2000, add 10mL of water to prepare a 0.25mol / L poly Acrylic acid solution was sonicated at a frequency of 45 kHz for 30 minutes to obtain a polyacrylic acid ultrasonic solution. The ultrasonic solution of cerium nitrate and the ultrasonic solution of polyacrylic acid were mixed uniformly, adjusted to pH=9 with ammonia water (25wt.%), and reacted at a constant temperature of 40° for 24 hours. After the reaction, the centrifuge was centrifuged at 5000r / min for 5min, and repeated once to remove the solid matter in the solution. Take the supernatant and use a 30KDa ultrafiltration centrifuge tube to separate and wash until the pH value=6; the liquid in the ultrafiltration centrifuge tube is the prepared sample, the cerium oxide nanoenz
Example Embodiment
[0067] Example 2
[0068] Take 2.2563g Gd(NO 3 ) 3 ·6H 2 O, add 5mL water, prepare 1mol / L gadolinium nitrate solution, ultrasonic for 1h, get gadolinium nitrate ultrasonic solution; take 5g polyacrylic acid (PAA) with an average molecular weight of 2000, add 10mL water, prepare 0.25mol / L polyacrylic acid (PAA) Acrylic acid solution was sonicated at a frequency of 45 kHz for 30 minutes to obtain a polyacrylic acid ultrasonic solution. The ultrasonic solution of gadolinium nitrate and the ultrasonic solution of polyacrylic acid were mixed uniformly by ultrasonic, adjusted to pH=11 with ammonia water (25wt.%), and reacted at a constant temperature of 40°C for 24 hours. After the reaction, the centrifuge was centrifuged at 5000r / min for 5min, and repeated once to remove the solid matter in the solution. Take the supernatant and use a 30KDa ultrafiltration centrifuge tube to separate and wash until pH=7; the liquid in the inner tube is the prepared sample gadolinium hydroxide nano
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