A novel composition for nonalcoholic fatty liver disease (NAFLD)

a technology for fatty liver disease and composition, applied in the field of novel composition for nonalcoholic fatty liver disease, can solve the problems of increased prevalence of steatohepatitis in non-insulin-dependent diabetes mellitus, weight loss, obesity patients who lost weight before death, etc., and achieve the effect of advanced liver scarring and advanced liver scarring

Inactive Publication Date: 2016-06-16
CADILA HEALTHCARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The technical effect described by this patented inventor relates to methods and compositions that can be used effectively against various diseases such as NAFL, NASH, hepatic fibrosis, etc., which are associated with excessive accumulated lipids called triglycerides within tissues due to insufficient production caused either through deficiency or overproduction of these substances during normal metabolism. This results from increased levels of certain enzymes involved in oxidation reactions needed throughout life.

Problems solved by technology

The patent text discusses nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic steatohepatitis (NASH). The text highlights that the cause and progression of these diseases, as well as their relation to other conditions like diabetes and obesity, are not well understood. It also mentions that there is currently no established therapy for NASH, with weight loss being a common recommendation. However, maintaining significant weight reduction is difficult for obese patients. Therefore, the technical problem addressed in this patent is the need to find a treatment for NAFLD and NASH that is effective and can be sustained by patients.

Method used

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  • A novel composition for nonalcoholic fatty liver disease (NAFLD)
  • A novel composition for nonalcoholic fatty liver disease (NAFLD)
  • A novel composition for nonalcoholic fatty liver disease (NAFLD)

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Embodiment Construction

[0019]The present invention describes a pharmaceutical composition for reduction and removal of lipid accumulated in the liver cells (hepatocytes), required for treating and preventing certain diseases and conditions in subject suffering from nonalcoholic fatty liver disease (NAFLD) including fatty liver (steatosis), nonalcoholic steatohepatitis (NASH), and cirrhosis (advanced scarring of the liver) and methods for ameliorating and / or treating such disease conditions.

[0020]The formulation comprises compound of formula (I) and the method comprises administering to a subject in need thereof an effective amount of a compound according to Formula (I), or a pharmaceutically acceptable salt thereof.

wherein ‘R’ is selected from hydroxy, hydroxyalkyl, acyl, alkoxy, alkylthio, thioalkyl, aryloxy, arylthio and M+ represents suitable metal cations such as Na+, K+, Ca+2, Mg+2 and the like.

DEFINITIONS AND ABBREVIATIONS

[0021]As used above, and throughout this disclosure, the following terms, unles

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Abstract

The present invention provides a compound of Formula (I) or pharmaceutical acceptable thereof, wherein ‘R’ is herein described. In addition, the invention relates to composition comprising effective therapeutic amount of compound of formula (I) and methods of using the compounds for treating or prevention disorder such as nonalcoholic fatty liver disease (NAFLD) including fatty liver (steatosis), nonalcoholic steatohepatitis (NASH), and cirrhosis (advanced scarring of the liver).

Description

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Claims

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Application Information

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Owner CADILA HEALTHCARE LTD
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