Application of a phillyrin/phillygeninin composition in preparing a medicine or health care product for alleviating or/and treating viral diseases, and medicine or health care product for treating viral diseases

Preparation of the Phillyrin / Phillygeninin Composition

[0048]Two monomer component powders, i.e., Phillyrin and phillygeninin, were separately weighted to mix according to the weight ratio shown in Table 1, to prepare a phillyrin / phillygeninin composition; the phillyrin monomer was manufactured by Dalian Fusheng Natural Drug Development Co., Ltd.; the purity thereof was determined to be 99.5%, determined by HPLC equipped with both UV detector and evaporative light-scattering detector (ELSD) using area normalization method, and the content thereof was calibrated and confirmed to be 99.5% with phillyrin standard available from China Pharmaceutical and Biological Products for content determination; phillygeninin was manufactured by Dalian Fusheng Natural Drug Development Co., Ltd., the purity thereof was determined to be 99.1%, determined by HPLC equipped with both UV detector and evaporative light-scattering detector (ELSD) using area normalization method

TABLE 1Raw material ratio tabl

Preparation of the Phillyrin / Phillygeninin Composition

[0049]The phillyrin / phillygeninin composition prepared in Example 1-4 was taken to be prepared into a composition comprising cydodextrin according to the weight ratio shown in Table 2 by using the following method: (1) directly adding to a cydodextrin solution, or (2) directly adding to a cydodextrin solution and well stirring for 1-24 h, (3) directly adding to a cydodextrin solution and heating for 10-120 min, (4) directly adding to a cydodextrin solution and performing ultrasonic treatment for 120 min, (5) directly grinding together with cydodextrin powder for 10-120 min, (6) mixing the phillyrin / phillygeninin composition well with the cydodextrin powder and sieving the mixture; (7) directly adding to a cydodextrin derivative solution, or (8) directly adding to a cydodextrin derivative solution and well stirring for 1-24 h, (9) directly adding to a cydodextrin derivative solution and heating for 10-120 min, (10) directly add

of the Phillyrin and Phillygeninin Composition

[0051]10 kg of 95% (n / m) ethanol was added to 1 kg of dried leaves of Forsythia suspensa, the mixture was reflux-extracted under heating twice for 2 h each time, the extracted liquid was filtered, the filtrate was concentrated under vacuum to ½ of the original volume, and was allowed to stand for precipitating at 25° C. for 1 h to separate out precipitates; the precipitates were dissolved with methanol for recrystallization, and precipitates were separated out; the above process was repeated for recrystallization with methanol to obtain an amorphous powder of a phillyrin / phillygeninin composition, with the contents of phillyrin and phillygeninin being 98% and 2% respectively, as determined by HPLC.