45results about "Capsule delivery" patented technology

The present invention is directed to a hard capsule filled with a solution containing an active ingredient, characterized in that the solution contains an inorganic chloride and has a water content (w) of 10<w≦80% and a water activity (a) of 0.50≦a≦0.90, and that the capsule is made of a base material containing a cellulose derivative. According to the present invention, a solution having high water content can be encapsulated, with its solution form being maintained. Thus, the present invention enables provision of a product which does not impair properties and stability of a drug or a similar substance, and does not impair sensation upon intake or eating sensation.

A health-care food in the form of soft-capsule, capsule, particle, tablet, or oral liquid for improving immunity and preventing and treating the injury of stomach mucosa is proportionally prepared from the oil of seabuckthorn fruit and the extract of propolis through mixing and shaping.

The invention provides novel curcuminoid formulations which have improved aqueous solubility and bioavailability when compared to known curcuminoid dosage forms. Formulations of the invention exhibit an enhanced intestinal absorption of curcuminoids, a slower curcuminoid metabolism and a reduced rate of systemic curcuminoid elimination. Additionally, upon administration in vivo, the formulations described and claimed herein produce a high, sustained level of the curcuminoid metabolite tetrahydrocurcumin. For example, at about eight to about ten hours after oral administration to a human, tetrahydrocurcumin plasma levels of between about 50 ng/mL to about 175 ng/mL are detectable, even when that metabolite is absent from the administered formulation. Novel processes for making curcuminoid formulations which have improved aqueous solubility and oral bioavailability, and methods of treating a wide variety of inflammatory, immune and neurogenerative disorders and cancers, are also provided.

An aqueous precipitation process for the preparation of particles comprising primarily silver sulfate, comprising reacting an aqueous soluble silver salt and an aqueous soluble source of inorganic sulfate ion in an agitated precipitation reactor vessel and precipitating particles comprising primarily silver sulfate, wherein the reaction and precipitation are performed in the presence of an aqueous soluble carboxylic acid additive or salt thereof, the amount of additive being a minor molar percentage, relative to the molar amount of silver sulfate precipitated, and effective to result in precipitation of particles comprising primarily silver sulfate having a mean grain-size of less than 70 micrometers.

The acne treating Chinese herbal medicine preparation is prepared with the active components of oldenlandia, loquat leaf, wolfberry bark, dandelion, capillary artemisia and other 21 kinds of Chinese medicinal materials. It is prepared into capsule, and has the features of short treating period, high curative effect and no toxic side effect.

A bifidobacteria colostrum-soluble soft capsule and a preparation method thereof. The invention relates to a bifidobacterium colon-soluble soft capsule and a preparation method thereof. The soft capsule includes two parts, a content and a rubber skin, and the shell of the soft capsule is processed to make it colon-soluble. The content of the soft capsule is a stable suspension prepared by mixing and stirring bifidobacterium freeze-dried powder, vegetable oil, suspending agent and wetting agent. In addition, the capsule shell has colonic solubility by impregnating the soft capsule with formaldehyde. The invention encapsulates the bifidobacterium freeze-dried powder soft capsule with vegetable oil as the carrier, has the effect of dissolving the colon, has good product stability, is convenient for transportation and storage, prolongs the shelf life, and jointly acts the bifidobacteria and vegetable oil on the colon , improve the disorder of intestinal flora, achieve the effect of laxative, and solve the pain caused by constipation. The invention is applied to the field of preparation of probiotics.

The invention provides a preparation method of capsules capable of activating blood and stopping pains. The preparation method comprises the following steps: taking six types of medicinal materials including 22g of Chinese angelica, 44g of radix notoginseng, 44g of vinegar processed frankincense, 11g of borneol, 111g of ground beetles and 67g of calcined pyrite; adding water with the weight which is 10 times as much as that of the medicinal materials; immersing for 0.5h and decocting for 1 hour; filtering and adding water with the weight which is 8 times as much as that of the medicinal materials into medicine residues; decocting for 1 hour and filtering medicine liquid; combining decocted liquid of the two times and concentrating until the relative density is 1.05 at 60 DEG C; adding ethanol until the volume percent of alcohol content reaches 75 percent; stirring, standing and filtering; concentrating filtrate until the relative density is 1.25 at 65 DEG C; recycling the ethanol to obtain a concentrated solution; carrying out super-critical extraction to obtain super-critical extract; continually concentrating and drying the concentrated solution; granulating and filling the capsules to obtain the capsules capable of activating blood and stopping pains. By adopting specific concentration and drying equipment, the prepared capsules capable of activating blood and stopping pains have high content of ferulic acid and can be applied to preparation of medicines for inhibiting Vero-E6 cell proliferation of African green monkey kidneys.

The invention relates to an active pure snake powder capsule and a preparation technique thereof. The invention adopts the technical scheme that the active pure snake powder capsule is prepared from Agkistrodon halys freeze-drying powder and black-tail snake freeze-drying powder according to the weight ratio of 2-3:1. The preparation technique comprises the following steps: delivering the washed Agkistrodon halys and the washed black-tail snake into a freezing dryer and freezing for 7-9 hours at negative 45 DEG C to negative 35 DEG C; starting a vacuum pump and heating to sublimate for 9-11 hours at 25-35 DEG C under a state of the vacuum degree of 1.3-13Pa; heating to sublimate for 11-13 hours at 55-65 DEG C; heating to sublimate for 9-11 hours at 75-85 DEG C; after vacuum drying, pulverizing the Agkistrodon halys and the black-tail snake coarsely by a roller respectively, then pulverizing finely and obtaining Agkistrodon halys freeze-drying powder and black-tail snake freeze-drying powder; and mixing the Agkistrodon halys freeze-drying powder and the black-tail snake freeze-drying powder evenly according to the weight ratio of 2-3:1, sieving with a sieve of 80 meshes and granulating a sieved substance by a capsule granulating machine after sterilizing by microwave. The invention can retain all the effective components of a snake, has curative effect to the three-high and is convenient to eat.

The invention relates to a Chinese medicinal preparation for treating spermophlebectasia, wherein the reactive constituents are prepared from the following raw materials (by weight portion): ledebouriella root 6-12, dahurian angelica root 6-9, dried orange peel 8-10, red peony root 6-9, Chinese angelica root 9-12, pangolin scales 9-12, Chinese honey locust 9-12, myrrh 3-5, licorice root 4-6, honeysuckle flower 10-15, root of Chinese trichosannthes 10-15, bupleurum root 4-6, Sichuan fritillary bulb 9-12, frank incense 3-6, phellodendron bark 8-10, plantain seeds 8-10. The medicament can be prepared into dose forms of oral liquids, capsules, tablets, pills or powders.

The present invention is a combination formulation of nutrient ingredients that have been selected and combined in quantities and concentrations that offer human nutritional support as shown in various literature. The present invention, also known as CATALYST GOLD, combines herbal, mineral, vitamin, and superfood supplements to help create a catalyst effect within the body to assist lasting permanent lifestyle and bodily changes. The selected nutrient ingredients provide nutritional support for a broad variety of conditions for example, individuals who are depleted due to chemotherapy, drug addiction, and general poor diet. The present invention also provides an easily orally dosed combination of nutrient ingredients in a small dosage form. The present invention may also be conveniently taken throughout the day to maximize support and ingredient quantities through repeat dosing.

The invention discloses a traditional Chinese medicine composition for preventing and treating epidemic meningitis. The traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 7-11 parts of raw rhubarb, 7-11 parts of mirabilite, 10-14 parts of immature bitter orange, 1-5 parts of mangnolia officinalis, 1-3 parts of purple snow elixir, 1.5-3.5 parts of rhinoceros horn, 12-17 parts of rhizoma anemarrhenae and 18-22 parts of lalang grass rhizome. The preparation method comprises the following steps: putting weighed the raw rhubarb, the mirabilite, the immature bitter orange, the mangnolia officinalis, the purple snow elixir, the rhinoceros horn, the rhizoma anemarrhenae and the lalang grass rhizome into a container; adding 8-fold water to decoct for 1.5 hours; filtering; adding 6-fold water to a residue; decocting for an hour; filtering, and merging filtrate; concentrating, drying and loading in capsule shells. A clinical experiment proves that the epidemic meningitis can be safely and effectively treated by the traditional Chinese medicine composition.

The invention discloses a medicine for treating viral pneumonia and a preparation method thereof and belongs to the field of traditional Chinese medicines. The effective components of the medicine comprise the following raw materials: lily, fructus psoraleae, jellyfish, cajeput, rosa bracteata, platycodon grandiflorum, Chinese pulsatilla root, justicia procumbens, kumquat, semen cassiae, broadleaf holly leaf, white strawberry, eucalyptus globulus, rhizoma bletillae, wikstroemia indica and reed stems. The medicinal materials adopted by the medicine are compatible, and the medicine conforms to the theory of traditional Chinese medicine and modern medicine, has the effects of clearing away heat and toxic materials, antisepsis and anti-inflammation, clearing diarrhea damp-heat, reducing phlegm and stopping coughing, and has significant curative effects on treating symptoms such as hyperpyrexia, slight aversion to chilliness, headache, bodily pain, cough and yellow sputum caused by viral pneumonia. The medicine has the advantages of short course of treatment, fast effectiveness, high safety and reliability, no toxic or side effects and no recurrence after curing, and the total effective rate of treating viral pneumonia is 97.8 percent.

The invention discloses a qianxi capsule and a preparation method thereof. The capsule is composed of Andrographis paniculata Nees and senecio according to a certain proportion. The preparation method comprises taking a part of the Andrographis paniculata Nees, crushing into fine powder, and sieving; crushing the residual Andrographis paniculata Nees and the senecio into crude powder, percolating, processing the percolating liquid, collecting deposition, and spray drying; adding the above Andrographis paniculata Nees fine powder, starch and proper amount of gelatin, uniformly mixing, preparing into particles, drying and filling to obtain the finish product. The qianxi capsule is safe and effective, has efficacies of clearing away heat and detoxifying, diminishing inflammation and relieving pain and stopping diarrhea shown by pharmacological and clinical studies, and can be clinically used for treating enteritis, colitis, bacterial dysentery, nasosinusitis, etc.

The invention discloses a technology for preparing a stomach floating type slow-release hollow capsule, and relates to the technical field of capsule materials. The technology comprises the followingsteps: 1, preparing a composite carrier; and 2, preparing the stomach floating type slow-release hollow capsule. The hollow capsule prepared in the invention belongs to the stomach floating type slow-release hollow capsule, the content filled capsule can floats on the gastric juice for a long time after entering the human gastric juice, and the content is slowly released from the shell wall of a capsule shell and enters the gastric juice to perform the effects of the slow-release content, so the retention time of the content in the stomach is effectively prolonged, and the release time of drugeffect molecules in the content is prolonged.

The invention discloses capsules for treating a cold. The capsules are prepared from, by weight, 10-15 parts of notopterygium roots, 5-8 parts of Chinese parsnip roots, 15-18 parts of rhizoma acori graminei, 9-13 parts of burdock, 6-9 parts of oriental stephania roots, 6-8 parts of apricot kernels, 1-3 parts of immature fruits of Terminalia chebula, 2-6 parts of flos farfarae and 6-8 parts of barbed skullcap herb. The capsules have the advantages of being prepared from various kinds of traditional Chinese medicinal materials, having the effects of clearing heat and promoting diuresis, dispelling wind and phlegm, ventilating lung and relieving exterior syndrome, tonifying qi and strengthening the foundation, being high in safety and having no side effect when taken for a long time.

An antihypertensive capsule for treating hypertension is prepared from 13 Chinese-medicinal materials including red sage root, wild chrysanthemum flower, Chuan-xiong rhizome, leech, etc through washing, slicing, drying in sun, pulverizing, sieving, proportional mixing and loading in capsules.

Disclosed herein are processes for preparing cyclic esters comprising unsaturated functional groups. Also disclosed are copolymers prepared from the cyclic esters. The copolymers can be used to form microparticles, polymer micelles, etc., which are useful in drug delivery applications.

The invention relates to a pharmaceutical composition for treating oral ulcer. The pharmaceutical composition is prepared from the following components by weight: 13 to 16 parts of VitB, 18 to 22 parts of VitE, 17 to 21 parts of a VitAD pill and 135 to 165 parts of mannatide. The pharmaceutical composition is a tablet coated by a layer of coating vitamin C. The coating vitamin C is prepared from, by weight, 13 to 18 parts of vitamin C and 2.5 to 4.2 parts of ethyl cellulose. The pharmaceutical composition has a reasonable component formula, is simple to prepare and comparable to a paste agent, a powder, a buccal tablet and a plaster membrane of a same kind for treatment of oral ulcer and has the advantages of easy administration, convenience in carrying, fast action, a good curative effect and wide applicability to oral ulcer resulting from a variety of causes.

The invention discloses a traditional Chinese medicinal composition for treating asthma. The traditional Chinese medicinal composition comprises elaeagnus conferta, lotus corniculatus, morinda parvifolia, lindera megaphylla, calabash-shaped leaves, thyme, sansevieria trifasciata, gentiana purdomii marq, cymbidium orchid, melilotus officinalis, and heliotropium indicum. The invention discloses a preparation method for the traditional Chinese medicinal composition. The traditional Chinese medicinal composition for treating the asthma has the advantages of good treatment effect, low cost, high cure rate, no adverse reaction and the like. The traditional Chinese medicinal composition disclosed by the invention has the effects of clearing heat, detoxifying, astringing the lung, nourishing the kidney, activating blood circulation, promoting the circulation of qi, tonifying qi, strengthening middle warmer and expelling phlegm to arrest coughing, and can recover vital energy and avoid the recurrence of the asthma.

The invention provides a traditional Chinese medicine for treating yin-deficiency fire-hyperactivity type neurasthenia and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicinal materials: citron fruit, herb of involucrate balanophora, herb of triquetrous tadehagi, root of beechey fig, dark brown part in licorice root, cholla stem, ziziphora bungeana, lethariella cladonioides, plum flower, officinal asparagus root, herb of common ammannia, bark of mongolian oak, entada sten, hairypistil acanthpanax, seed of chingma abutilon, creeping pothos and bulb of longroot onion. The traditional Chinese medicine provided by the invention has the advantages of strong pertinence, obvious curative effect and small side effects for treating the yin-deficiency fire-hyperactivity type neurasthenia.

The invention relates to a Chinese herb preparation powder capsule capable of treating hyperostosis, and the Chinese herb preparation powder capsule is prepared from the following raw materials in parts by weight: 4-12 parts of little multibanded krait, 4-12 parts of sea horse, 4-12 parts of pseudo-ginseng, 3-9 parts of cynomorium songaricum, 3-9 parts of asarum, 3-9 parts of radix clematidis, 3-9 parts of subprostrate sophora, 3-9 parts of Chinese starjasmine stem, 3-9 parts of myrrh, and 3-9 parts of mastic. The Chinese herb preparation powder capsule is prepared by virtue of the following steps: soaking in guogong jiu, steaming at high temperature, baking and drying, smashing into fine powder, and packing into capsules. The Chinese herb preparation powder capsule capable of treating hyperostosis has special and quick effects and high cure rate, and the hyperostosis does not relapse.

The invention relates to a traditional Chinese medicine capsule for treating atrioventricular block. The traditional Chinese medicine capsule is characterized by being prepared from the following steps: extracting a concentrated solution from fried astragalus membranaceus, ligusticum wallichii, fructus trichosanthis, allium macrostemon, processed rhizoma pinelliae, raw hawthorns and cordyceps sinensis, preparing extract, then drying, crushing, sterilizing and packing into capsules.