Technology for preparing stomach floating type slow-release hollow capsule

[0026] (1) Preparation of composite carrier: Add dropwise 40-45°C deionized water to 15g food grade polyglutamic acid under stirring until completely dissolved, and add dropwise 5wt% dilute sulfuric acid to adjust the pH value of the solution to be stable at 3 within 10min. -4, add 5g poloxamer 188 and 3g polyethylene glycol 4000, add 40-45 ℃ deionized water under stirring to completely dissolve poloxamer and polyethylene glycol 4000, and heat up to reflux state to keep warm Stir for 3 hours, then cool down to 0-5°C at a cooling rate of 5-10°C / min and keep stirring for 30 minutes. The resulting mixture is sent to a freeze dryer, and the dried solid is made into a fine powder by an ultrafine pulverizer to obtain a composite carrier;

[0027] (2) Preparation of stomach-floating sustained-release hollow capsules: Add 2 g of food-grade sodium polyacrylate and 1 g of hydrogenated palm oil to the prepared 15 g composite carrier, mix well, and use a microwave processor to treat with mi

[0030] (1) Preparation of composite carrier: Add dropwise 40-45°C deionized water to 15g food grade polyglutamic acid under stirring until completely dissolved, and add dropwise 5wt% dilute sulfuric acid to adjust the pH value of the solution to be stable at 3 within 10min. -4, add 10g Poloxamer 407 and 5g Polyethylene Glycol 4000, add 40-45°C deionized water under stirring to completely dissolve Poloxamer and Polyethylene Glycol 4000, and heat up to reflux state to keep warm Stir for 3 hours, then cool down to 0-5°C at a cooling rate of 5-10°C / min and keep stirring for 30 minutes. The resulting mixture is sent to a freeze dryer, and the dried solid is made into a fine powder by an ultrafine pulverizer to obtain a composite carrier;

[0031] (2) Preparation of stomach-floating sustained-release hollow capsules: Add 3 g of food-grade sodium polyacrylate and 2 g of hydrogenated palm oil to the prepared 20 g composite carrier, mix well, and use a microwave processor to treat with m

[0034] (1) Preparation of composite carrier: Add dropwise 40-45°C deionized water to 15g food grade polyglutamic acid under stirring until completely dissolved, and add dropwise 5wt% dilute sulfuric acid to adjust the pH value of the solution to be stable at 3 within 10min. -4, add 10g Poloxamer 407 and 5g Polyethylene Glycol 4000, add 40-45°C deionized water under stirring to completely dissolve Poloxamer and Polyethylene Glycol 4000, and heat up to reflux state to keep warm Stir for 3 hours, then cool down to 0-5°C at a cooling rate of 5-10°C / min and keep stirring for 30 minutes. The resulting mixture is sent to a freeze dryer, and the dried solid is made into a fine powder by an ultrafine pulverizer to obtain a composite carrier;

[0035](2) Preparation of stomach-floating sustained-release hollow capsules: Add 3 g of food-grade sodium polyacrylate and 2 g of hydrogenated palm oil to the prepared 20 g composite carrier, mix well, and use a microwave processor to treat with mi