Low-cost medicine coating method

[0031] The present embodiment provides a low-cost drug coating method, which specifically includes the following steps:

[0032] 1) Deposit a coating layer on the solid particle drug by ALD method to obtain ALD-coated modified drug.

[0033] The specific operation process of the ALD method is as follows: First, put the drug particles into a porous container with micropore size, put the porous container into the reaction chamber, vacuumize and replace the nitrogen three times, the temperature of the reaction chamber is raised to 50°C, and the reaction chamber maintains At a pressure of 5 torr, the porous container is rotated again so that the drug particles are fully mixed in the cavity of the porous container; then, the precursor Al(CH 3 ) 3 N at 15 sccm flow rate 2 Carry the lower pulse into the reaction chamber, adsorb on the drug particles, the pulse time is 10s, and then use 1000sccmN 2 Purge and take away the remaining Al(CH 3 ) 3 , N 2 The flushing time is 10s, the...

[0048] The present embodiment provides a low-cost drug coating method, which specifically includes the following steps:

[0049] 1) Deposit a coating layer on the solid particle drug by ALD method to obtain ALD-coated modified drug.

[0050] The specific operation process of the ALD method is as follows: First, put the drug particles into a porous container with micropore size, put the porous container into the reaction chamber, vacuumize and replace the nitrogen three times, the temperature of the reaction chamber is raised to 50 °C, and the nitrogen flow is used. The method is to make the powder suspended and fully mixed in the porous cavity, and the nitrogen flow rate is 5000 sccm; then, the precursor TiCl for atomic layer deposition 4 N at 30sccm flow rate 2 Carried by the pulse into the reaction chamber, adsorbed on the drug particles, the pulse time is 60s, until the air pressure reaches 6torr, and then with 500sccm N 2 Purge and take away remaining TiCl 4 , N 2 The ...

[0056] The present embodiment provides a low-cost drug coating method, which specifically includes the following steps:

[0057] 1) Deposit a coating layer on the solid particle drug by ALD method to obtain ALD-coated modified drug.

[0058] The specific operation process of the ALD method is as follows: First, put the drug particles into a porous container with micropore size, put the porous container into the reaction chamber, vacuumize and replace the nitrogen three times, the temperature of the reaction chamber is raised to 150°C, and the reaction chamber maintains At the pressure of 5torr, rotate the porous container again, so that the drug particles are fully mixed in the porous container cavity; then, the precursor Zr[N(CH3) used for atomic layer deposition 2 ] 4 N at 50sccm flow rate 2 Carry the lower pulse into the reaction chamber, adsorb on the drug particles, the pulse time is 60s, until the air pressure reaches 6torr, and then use 50sccm N 2 Purge and take away...