Hard capsule

a hard capsule and capsule technology, applied in the field of hard capsules, can solve the problems of high water content, affecting the taste, odor, properties, and components of capsules, and affecting the marketability of capsules, etc., to achieve the effect of not impairing the properties and stability of drugs, not impairing the taste or texture of intake, and high water conten

Inactive Publication Date: 2006-07-13
WAKUNAGA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes how to make sure that certain drugs like nicotine have good taste when taken by people who don't want them smoked. They also found it easier to put these medications inside small packets made from plastic material instead of traditional packaging materials such as glass bottles. These tiny packets were easy to store for longer periods but they didn't affect any important qualities or characteristics of the medicine. Additionally, there was no harmful chemical added to the medicine. Overall, this technology allows users to take more consistently safe products while still giving them better flavorings.

Problems solved by technology

The technical problem addressed in this patent text relates to the difficulty of producing stable and effective capsules that contain liquids without losing their original flavors during storage due to volatile organic chemicals released from these materials. This issue becomes even more challenging because it may require expensive processes involving multiple steps and long periods of time.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0046] An aqueous sodium chloride solution containing a ginseng extract was prepared so that the water content was 74% or 78% and the water activity was 0.80 or 0.83. The solution was placed in #0 capsules made of hydroxypropyl methylcellulose, and the joining portion of the capsule body and its corresponding cap was sealed with an aqueous ethanol solution of hydroxypropyl methylcellulose, followed by drying in air. The resultant capsule samples were put in glass bottles, and stored at 40° C. for one month. Whether there had been any leakage of the internal solution from the hard capsules was visually checked. The results are shown in Table 1. Neither leakage of internal solution from the hard capsules nor change of the capsule shape was observed.

TABLE 1Water content (%)7478Water activity0.800.83Sodium chloride0.300.26concentration (g / mL)40° C., one monthNo liquidNo liquidleakageleakage

example 2

[0047] An aqueous calcium chloride solution containing a ginseng extract was prepared so that the water content was 67% or 70% and the water activity was 0.75 or 0.78. The solution was placed in #0 capsules made of hydroxypropyl methylcellulose. Subsequently, the capsule was sealed in a manner similar to that employed in Example 1, followed by drying in air. The resultant capsule samples were put in glass bottles, and stored at 40° C. for one month. Whether there had been any leakage of the internal solution from the hard capsules was visually checked. The results are shown in Table 2. Neither leakage of internal solution from the hard capsules nor change of the capsule shape was observed.

TABLE 2Water content (%)6770Water activity0.750.78Calcium chloride0.410.37concentration (g / mL)40° C., one monthNo liquidNo liquidleakageleakage

example 3

[0048] An aqueous magnesium chloride solution containing a ginseng extract was prepared so that the water content was 66% or 70% and the water activity was 0.53 or 0.60. The solution was placed in #0 capsules made of hydroxypropyl methylcellulose. Subsequently, the capsule was sealed in a manner similar to that employed in Example 1, followed by drying in air. The resultant capsule samples were put in glass bottles, and stored at 40° C. for one month. Whether there had been any leakage of the internal solution from the hard capsules was visually checked. The results are shown in Table 3. Neither leakage of internal solution from the hard capsules nor change of the capsule shape was observed.

TABLE 3Water content (%)6670Water activity0.530.60Magnesium chloride0.450.40concentration (g / mL)40° C., one monthNo liquidNo liquidleakageleakage

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Abstract

The present invention is directed to a hard capsule filled with a solution containing an active ingredient, characterized in that the solution contains an inorganic chloride and has a water content (w) of 10<w≦80% and a water activity (a) of 0.50≦a≦0.90, and that the capsule is made of a base material containing a cellulose derivative. According to the present invention, a solution having high water content can be encapsulated, with its solution form being maintained. Thus, the present invention enables provision of a product which does not impair properties and stability of a drug or a similar substance, and does not impair sensation upon intake or eating sensation.

Description

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Claims

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Application Information

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Owner WAKUNAGA PHARMA CO LTD
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