Aqueous composition for enteric hard capsule, method of preparing enteric hard capsule, and enteric hard capsule prepared using the method

Active Publication Date: 2012-06-28
LOTTE FINE CHEM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, since the use of gelatin is limited due to mad cow disease or the like, an HPMC capsule formed of a plant-based material without using gelatin has been widely used.
However, since the capsule is orally administered, disintegrated by gastric juice and absorbed in the body, it may not be used in case that main ingredients and excipients of pharmaceutical preparations and functional foods filled in the capsule are instable in an acid, irritate the stomach, or generate an odor that can be regurgitated.
However, for the

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  • Aqueous composition for enteric hard capsule, method of preparing enteric hard capsule, and enteric hard capsule prepared using the method

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[0050]Aqueous compositions having compositions listed in Table 1 below were prepared according to the following method, and enteric capsules were prepared in the conditions listed in Table 2 below. Then, each of the prepared capsules was immersed in a test solution having the pH of 1.2 that is similar to gastric juice for maximum 2 hours to observe whether it disintegrate or not, and then immersed in a test solution having the pH of 6.8 that is similar to small intestinal juice to measure disintegration time.

[0051]The results are shown in Table 2 below.

[0052]Preparation of Aqueous Composition

[0053]A neutralizing agent, an emulsifier, and a plasticizer, and selectively, a colorant were added to water, and an enteric base material and a capsule forming aid were added thereto and dissolved therein to prepare aqueous compositions.

[0054]Preparation of Enteric Capsule

[0055]The temperature of each of the aqueous compositions prepared as described above was controlled to be less than a thermal

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Abstract

An aqueous composition for an enteric hard capsule, a method of preparing an enteric hard capsule, and an enteric hard capsule prepared using the method. The aqueous composition for an enteric hard capsule includes an enteric base material, a capsule forming aid, and a neutralizing agent. The method of preparing an enteric hard capsule includes: preparing an aqueous composition by dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water; preheating the aqueous composition to a temperature that is less than the gelation temperature for the aqueous composition; immersing a mold pin heated to a temperature that is greater than the gelation temperature for the aqueous composition into the aqueous composition; taking the mold pin out of the aqueous composition to obtain a film formed on the mold pin; and maintaining the film at a temperature that is equal to or greater than the gelation temperature for the aqueous composition for a predetermined period of time to fix the film on the mold pin and drying the film.

Description

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Claims

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Application Information

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Owner LOTTE FINE CHEM CO LTD
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