The invention discloses
acarbose pharmaceutical composition and a preparation method thereof in order to overcome defects that conventional
acarbose tablets are prone to
moisture absorption, slow to disintegrate, difficult to prepare and the like. The
acarbose pharmaceutical composition is prepared from components in parts by weight as follows: 1 part of the acarbose, 1-4 parts of a filling agent, 0.001-0.005 parts of a lubricating agent and 0.005-0.01 parts of a flow aid, wherein the filling agent comprises
microcrystalline cellulose and
pregelatinized starch. The preparation method comprises steps as follows: the acarbose and the
pregelatinized starch with good fluidity are subjected to first-stage mixing, a mixture and the residual filling agent are subjected to second-stage mixing, and finally, the lubricating agent and the flow aid are added for third-stage mixing. The acarbose pharmaceutical composition is free of a disintegrating agent, and a disintegration property of a product is realized by the aid of disintegration performance or a disintegration assistant effect of auxiliary material characteristics of the
pregelatinized starch and the
microcrystalline cellulose. The requirement for product quality is met with a staged mixing and
powder direct-tabletting technology, the technology is simple, and large-scale production is facilitated.