The invention provides a preparation method of
domperidone tablets, comprising the following steps: (1) material preparation: performing site-clearing inspection, getting a
raw material domperidone, and ingredients
lactose G200,
pregelatinized starch, low-substituted
hydroxypropyl cellulose, povidone K30, lauryl
sodium sulfate, silica and
magnesium stearate; (2) pelleting: sieving and uniformly mixing
raw material and ingredients except povidone K30, silica and
magnesium stearate, then slowly adding a povidone K30 solution, uniformly stirring, and sieving to prepare wet particles,
drying, sieving and collecting to obtain dry particles; (3) generally blending: respectively adding silica and
magnesium stearate into the dry particles obtained in the step (2), to obtain generally mixed particles; and (4) tabletting, and the like. The method is high in production efficiency, and can enable the prepared
domperidone tablets to be high in dissolving-out speed and relatively long in expirationdate while ensuring relatively high
streptomycin hardness.