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5 results about "Mannitol" patented technology

Mannitol is a type of sugar alcohol used as a sweetener and medication. As a sweetener it is used in diabetic food as it is poorly absorbed from the intestines. As a medication, it is used to decrease pressure in the eyes, as in glaucoma, and to lower increased intracranial pressure. Medically, it is given by injection. Effects typically begin within 15 minutes and last up to 8 hours.

Detection method of mannitol in cordyceps fungus powder (Cs-4)

InactiveCN110133129AEffective quality controlImprove accuracyComponent separationCordycepsMicropore Filter
The invention relates to a detection method of mannitol in cordyceps fungus powder (Cs-4). The method comprises the steps of 1, preparation of a test substance solution, wherein an appropriate amountof cordyceps fungus powder (Cs-4) is taken, weighed precisely and added into an ethanol solution, the mixture is weighed, heated for reflux, cooled and weighed again, lost weight is supplemented by the ethanol solution, filtering is performed, an appropriate amount of subsequent filtrate is taken and placed in an evaporation dish, the subsequent filtrate is subject to decompression drying to be almost dry, residues are dissolved into a volumetric flask through a mobile phase and pass through a 0.45-micron micropore filtering membrane, and subsequent filtrate is taken to serve as the test substance solution; and 2, preparation of a reference substance solution, wherein an appropriate quantity of D-mannitol reference substances is taken, weighed precisely and dissolved by adding the mobile phase, and the reference substance solution is obtained; and 3, determination, wherein the reference substance solution and the test substance solution are sucked respectively and precisely and injected into a liquid chromatograph, a chromatogram is obtained through determination, and the content of D-mannitol (C<6>H<14>O<6>) is calculated according to the chromatogram.
Owner:JIANGXI GUOYAO PHARMA LLC

Preparation method of phosphatidylglycerol monosodium salt containing two different side chains

PendingCN111057100AHigh purityHigh yieldPhosphatide foodstuff compositionsPhosphorus organic compoundsSide chainPhospholipid
The invention belongs to the technical field of compound preparation. The invention relates to a preparation method of phosphatidylglycerol monosodium salt, in particular to a preparation method of phosphatidylglycerol monosodium salt containing two different side chains. The preparation method comprises the following steps: taking D-mannitol as an initial raw material, heating D-mannitol in acetone to generate 1,1,5,6-isopropylidene-D-mannitol; carrying out sodium periodate oxidation and sodium borohydride reduction to obtain iso-propylidene glycerol; carrying out condensation reaction with fatty acid containing an R1 element, then removing acetal protective groups in the presence of acid; selectively protecting primary hydroxyl by using a silane protective agent, reacting secondary hydroxyl with another fatty acid containing a R2 element, removing silane protection, reacting the de-protected product with phosphorus oxychloride and iso-propylidene glycerol, removing acetal protectivegroups by using an acid, and finally carrying out a sodium salt treatment to obtain a final product. The synthesis of phosphatidyl monosodium salt containing two different side chains can be realized,and the production process is simple, environment-friendly and easy to operate.
Owner:HEFEI BOSIKC PHARMTECH CO LTD
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