Glipizide orally disintegrating tablet and preparation method thereof

[0029] prescription:

[0030]

[0031]

[0032] Wherein, the amount of binder purified water is 11g, accounting for 26.8% of the total weight of glipizide, mannitol, microcrystalline cellulose and low-substituted hydroxypropyl cellulose with a total addition of 50%.

[0033] A preparation method of glipizide orally disintegrating tablet, is characterized in that, comprises the following steps:

[0034] S1. Mix 5 g of glipizide, 20 g of mannitol, microcrystalline cellulose and low-substituted hydroxypropyl cellulose in a total amount of 50%, and pour it out through a 60-mesh sieve to form mixed powder I;

[0035] S2. Add 11g of purified water to make soft material into the powder mixing I in step S1, pass the soft material through a 30-mesh sieve to make wet granules;

[0036] S3, drying the wet granules, controlling the drying temperature of the wet granules to 80°C until the water content of the granules is lower than 3%, to obtain dry granules;

[0037] S4, the dry g...

[0043] prescription:

[0044]

[0045] Wherein, the amount of binder purified water is 16g, accounting for 33.4% of the total weight of glipizide, mannitol, microcrystalline cellulose and low-substituted hydroxypropyl cellulose with a total addition of 50%.

[0046] A preparation method of glipizide orally disintegrating tablet, is characterized in that, comprises the following steps:

[0047] S1. Mix 5 g of glipizide, 33 g of mannitol, microcrystalline cellulose and low-substituted hydroxypropyl cellulose in a total amount of 50%, and pour it out through a 70-mesh sieve to form mixed powder I;

[0048] S2. Add 16g of purified water to make soft material in step S1 mixed powder I, pass the soft material through a 20-mesh sieve to make wet granules;

[0049] S3, drying the wet granules, controlling the drying temperature of the wet granules to 75°C until the water content of the granules is lower than 3%, to obtain dry granules;

[0050] S4, the dry granules are passed thr...

[0056] prescription:

[0057]

[0058] Wherein, the amount of binder purified water is 14g, accounting for 34.1% of the total weight of glipizide, mannitol, microcrystalline cellulose and low-substituted hydroxypropyl cellulose with a total addition of 50%.

[0059] A preparation method of glipizide orally disintegrating tablet, is characterized in that, comprises the following steps:

[0060] S1. Mix 5 g of glipizide, 20 g of mannitol, microcrystalline cellulose and low-substituted hydroxypropyl cellulose in a total amount of 50%, and pour it out through a 60-mesh sieve to form mixed powder I;

[0061] S2. Add 14g of purified water to make soft material into the powder mixing I in step S1, pass the soft material through a 30-mesh sieve to make wet granules;

[0062] S3, drying the wet granules, controlling the drying temperature of the wet granules to 80°C until the water content of the granules is lower than 3%, to obtain dry granules;

[0063] S4, the dry granules are ...