9 results about "Micelle" patented technology

Crystalline superfine particles capable of emitting light depending upon a time-rate-of-change of a stress and controlled in grain size in the range from 5 nm to 100 nm are complexed with another material such as resin. The crystalline superfine particles are manufactured by using aggregates of molecules, i.e. inverted micelles, which orient hydrophilic groups of surfactant molecules inward and hydrophobic groups outward in a nonpolar solvent and which contain metal ions of a metal for forming the crystalline superfine particles dissolved in water inside the inverted micelles. Alternatively, they are manufactured by using inverted micelles enveloping precursor superfine particles, in which precursor superfine particles are enveloped in water inside the inverted micelles. The crystalline superfine particles are excellent in dispersibility in another material to be complexed, enhanced in emission efficiency and usable to make a transparent stress emission material. The complex material obtained is used to manufacture artificial light-emitting hair structures, artificial light-emitting skin, artificial light-emitting bodies, artificial light-emitting fabrics, and others.

The invention discloses a small micelle nano-drug and a preparation method and application thereof. A micromolecule drug and an amphiphilic polymer/targeted amphiphilic polymer are added into polycthylene glycol oilgomers to obtain a mixed solution, then the mixed solution is added into a buffer solution to obtain the small micelle nano-drug; and the molecular weight of the polycthylene glycol oilgomers is 200-600. The invention designs and prepares an efficient paclitaxel PTX-loaded micelle MPTX, a disulfide cross-linked micelle MPTX and three TNBC active targeting micelle nano-drug, the drug loading capacity is up to 23.1 wt.%, the particle size is less than 40 nm, and the micelle nano-drug has good stability and drug release performance of reduction response.

The invention discloses a preparation method of double-response hydrogel ink. The method specifically comprises the steps of: firstly, preparing acryloylated F127, polymerizing and crosslinking the acryloylated F127 by using free radicals, then preparing a methacryloylated quaternary ammonium salt chitosan solution, then dissolving the cross-linked acryloylated F127 in water, adding the methacryloylated quaternary ammonium salt chitosan solution, conducting uniform stirring, adding a photoinitiator, conducting heating, and finally conducting light initiating cross-linking by using 405 nm lightof 5-10 W to prepare hydrogel, so as to obtain the double-response hydrogel ink. According to the method, chemically cross-linked F127 micelles are formed by pre-cross-linking acrylated F127, and after the chemically cross-linked F127 micelles are assembled with micellizable methacrylated quaternary ammonium salt chitosan, reversible temperature-sensitive hydrogel can be obtained, and the sol-geltransformation temperature of the reversible temperature-sensitive hydrogel can be adjusted between 28 DEG C and 40 DEG C, the mechanical strength of the gel can be adjusted and controlled through photoresponse, and the microenvironment mechanical requirements for repairing skin, cartilages and other tissues are met.

The invention provides a composition for eyes and having improved drying protection and retention, and belongs to the field of pharmaceutical preparations. The composition includes cyclosporin, nano micelle in-situ gel, and hyaluronic acid or a pharmaceutically acceptable salt thereof; and the composition is in a liquid form at normal temperature or low temperature, is a hydrosol form when the temperature is more than 35 DEG C, and can still maintain complete under the shear stress caused by the eyelid blinking of patients. A preparation method includes providing first solute and second solute; and mixing the solute under a condition of taking water as a substrate so that the composition including gel dispersoid can be formed. The provided composition is high in bioavailability and small in effect on eye pain and irritation, cannot cause the blurring of vision, can improve the compliance of the patients and/or reduce side-effects, can enhance ocular surface health, and has antibacterial and antiseptic effects; and the preparation method can increase adhesiveness, enhance gelation temperature, prolong retention and effective acting time, rising encapsulation yield, avoid self-agglomeration phenomenon, and enhance antioxidant protection effects and stability performance.

The invention provides a preparation method and application of a chitosan-g-poly(epsilon-caprolactone) derivative drug-loaded nano-micelle. According to the invention, chitosan and a poly(epsilon-caprolactone) derivative provided are used for the drug-loaded nano-micelle; the preparation method is simple in process and convenient in operation; a drug with poor water solubility can be encapsulatedand conveyed, the systemic toxicity of the drug is reduced, the biocompatibility of a carrier is improved, and the curative effect of the drug is improved; and the chitosan-g-poly(epsilon-caprolactone) derivative drug-loaded nano-micelle disclosed by the invention has hydrophobic groups and hydrophilic groups which are easily degraded in a living body, can be used as a novel drug-loaded nano-micelle, has a wide substantive application scope, and has very important practical value for treating tumors.

Described herein are linear peptides for creation of colloidal particles and micelles for delivery of active agents. The colloidal particles facilitate encapsulation and delivery of hydrophobic and/or poorly water soluble active agents within the particle hydrophobic core. The compositions are suitable for delivery of active agents to plants and animals.

The invention discloses a nanogold micelle catalyst as well as a preparation method and an application thereof, and belongs to the technical field of nanogold micelle catalysts. For solving the problem that a high-efficiency catalyst is lacked in preparation of fatty acid ester by aqueous phase conversion of bio-based fatty alcohol, the invention provides the nanogold micelle catalyst as well as the preparation method and the application thereof. The preparation method of the nanogold micelle catalyst provided by the invention comprises the following steps: mixing an HAuCl4 aqueous solution and an mPEG-SH aqueous solution; stirring for 30-50 min at the temperature of 20-30 DEG C and the rotating speed of 500-1000 rpm, then dropwise adding a NaBH4 aqueous solution into the solution, stirring while dropwise adding, carrying out a reaction for 12-24 h to obtain an mPEGylated Au-NPs solution, and centrifuging to obtain a supernatant, namely the nanogold micelle catalyst. The nanogold micelle catalyst disclosed by the invention can be used for efficiently catalyzing water-phase oxidation of fatty alcohol to prepare fatty acid ester.