9 results about "Drug release" patented technology

The invention discloses a focused ultrasound-polymeric micelle controllable drug release device and a release method thereof. The device is characterized by consisting of a focused ultrasound system and a drug loaded polymeric micelle system, wherein the focused ultrasound system is connected with a focused ultrasound energy converter (3) by a signal generator (1) through a power amplifier (2); the drug loaded polymeric micelle system consists of a complex micelle (5) formed by amphiphilic block copolymers and drugs and a medium (4); and a drug loaded polymeric micelle is internally provided with a sensor (6) which is connected with a computer (8) through a signal processor (7). The focused ultrasound-polymeric micelle controllable drug release method comprises the step that the drug carried polymeric micelle is prepared through a dialysis method or a solvent evaporation method, and under ultrasonic irradiation, the polymeric micelle responds to ultrasound through a physical or chemical change so as to ensure that loaded hydrophobic drugs are released from the micelle and enter a focal part.

The invention provides a preparation method of an LCZ696 sustained release matrix tablet. The specific prescription of the LCZ696 sustained release tablet comprises (g/g): 40% of a main drug, 10%-20% of a matrix material, 30%-40% of a diluent, and 5%-10% of a lubricant. The preparation method consists of: sieving the raw and auxiliary materials by a 80-mesh sieve respectively for standby use, firstly mixing the main drug with the matrix material evenly, then adding the diluent and the lubricant and mixing the materials evenly, and performing all powder direct compression, thus obtaining the LCZ696 sustained release matrix tablet. The sustained release tablet is used for medication once every 24h, and the number of medication times is reduced. After oral taking, drugs are released slowly, the blood concentration is stable, and peak valley phenomenon is not generated. Also, the toxic and side effects of drugs are reduced.

The invention is to disclose a medicine of external use for treating skin disease And its preparation method, said medicine includes materials according to part by weight as follows: egocort 6-9 ; camphor 80-120;menthol 80-120;triamcinolone acetonaide acetate 8-12;carbamide 800-1200;aspirin 440-4400.

The invention discloses a temperature-sensitive wall material. The temperature-sensitive wall material comprises a temperature-sensitive material modified polymer wall material, wherein the temperature-sensitive material is polyvinylpyrrolidone, glycerophosphate, stearic acid, galactose-removed xyloglucan or gelatin-chitosan, poly(N-isopropylacrylamide) and hydroxybutyl chitosan. The temperature-sensitive wall material releases drugs at different temperatures, the drug release time is flexibly controlled, the phytotoxicity is reduced, and the drug action time is prolonged. The temperature-sensitive wall material can be applied to whole-course pesticide application protection of the growth cycle of crops, the chemical application frequency is reduced, and the crop management efficiency is improved. The invention also provides a corresponding microcapsule and a preparation method.

The invention discloses a small micelle nano-drug and a preparation method and application thereof. A micromolecule drug and an amphiphilic polymer/targeted amphiphilic polymer are added into polycthylene glycol oilgomers to obtain a mixed solution, then the mixed solution is added into a buffer solution to obtain the small micelle nano-drug; and the molecular weight of the polycthylene glycol oilgomers is 200-600. The invention designs and prepares an efficient paclitaxel PTX-loaded micelle MPTX, a disulfide cross-linked micelle MPTX and three TNBC active targeting micelle nano-drug, the drug loading capacity is up to 23.1 wt.%, the particle size is less than 40 nm, and the micelle nano-drug has good stability and drug release performance of reduction response.

The invention relates to a medical apparatus, in particular to a prosthesis component for drug-release treatment of postoperative infection of joint. The prosthesis component comprises a joint prosthesis and a joint stem prosthesis, wherein medicine accommodating cavities are formed in the joint prosthesis and the joint stem prosthesis. The joint prosthesis, compared with a conventional spacer, has a joint prosthesis moving function, and the joint prosthesis can keep the stability of joints while guaranteeing the daily activities of the joints; meanwhile, the interior of the joint prosthesis is subjected to hollow design and is provided with the medicine accommodating cavity for accommodating medicines; and the medicines, after being injected, are released in a sustained mode, so that continuous administration to an infected articular cavity is achieved, and subsequently, the infection is cured; and meanwhile, the problem that treatment becomes invalid due to the generation of a great amount of debris caused by fractures in the conventional spacer is avoided.