45 results about "Chemical compound" patented technology

A method of modifying the content of certain chemical compounds in tobacco materials is provided, the method including treatment of a tobacco plant component with at least one probiotic. For example, the method may modify the asparagine content in tobacco materials, which can result in a modification in acrylamide production when the tobacco material is exposed to elevated temperatures. The type of tobacco plant component treated according to the invention can be a tobacco seed, a tobacco seedling, an immature live plant, a mature live plant, a harvested plant, or a portion thereof. Examples of probiotics include probiotic species of the genera bifidobacterium, lactobacillus, enterococcus, proionobacterium, bacillus, saccharomyces, streptococcus, and mixtures thereof. Smoking articles and other tobacco products including such probiotic-treated tobacco materials are also provided.

The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

The invention provides a stripping gold component which could remove gold from substrate, comprising: a stripping gold chemical compound; and a assistant conductive compound wherein said stripping gold chemical compound bonds with gold to form covalent bond to strip gold from said substrate, said assistant conductive chemical compound helps the electric conduction and decreases the voltage, said substrate would not be damaged after stripping gold from said substrate, and the stripping gold component is cyanide free.

The invention discloses an online purification solid-phase extraction monolithic column and a preparation method and purposes of the monolithic column. The monolithic column comprises a column pipe and a column body generated by in-situ polymerization in the pipe, wherein the column body is a polymer of butyl methacrylate-ethylene glycol dimethacrylate. According to the monolithic column, the surface of the bed of the monolithic column is provided with C4 groups, and the column structure is continuous and porous and has a certain mechanical strength and biocompatibility. Compared with a traditional filling extraction column, the online purification solid-phase extraction monolithic column has the characteristics of filling simplicity, low reaction pressure, repeated utilization and high extraction efficiency and can be used for online purification and enrichment of Sudan red in hot pepper products and glucocorticoid and other weak polarity compounds in milk. The technology provides a novel path for rapidly analyzing pollutants in food.

The present invention discloses a novel anti-PD-L1 compound and applications thereof, and a composition containing the novel anti-PD-L1 compound, and provides a substituted biaryl compound representedby a formula I, a pharmaceutically acceptable salt, a hydrate, a solvate, a metabolite, a stereoisomer, a tautomer or a prodrug thereof. The formula I is defined in the specification.

The invention discloses an unleaded piezoelectric ceramic consisting of a B-site composite Bi-based compound and a preparation method thereof. The components of the unleaded piezoelectric ceramic are shown by the general formulae of (1-x) Bi (Li1/2Me1/2) O3 - xBaTiO3 + zMaOb, (1-x) Bi (Li1/2Me1/2)O3 - x (Na1/2Bi1/2)TiO3 + zMaOb, (1-x-y) Bi (Li1/2Me1/2) O3 - xBaTiO3 - y (Na1/2Bi1/2) TiO3 + zMaOb, (1-x-y) Bi (Li1/2Me1/2) O3 - xBaTiO3 - y (K1/2Bi1/2) TiO3, + zMaOb or (1-x-y-v) Bi (Li1/2Me1/2) O3 - xBaTiO3 - y (Na1/2Bi1/2) TiO3 - v(K1/2Bi1/2) TiO3 + zMaOb, wherein x, y, z and v denote mole fractions, 0 (x (1.0,0 (y (1,0 (v (1, 0</= z</=0.1, Me represents one or five pentavalent metallic elements, MaOb represents one or a plurality of oxides, M is an element of +1 to +6 valence, and can be formed into a solid oxide with oxygen, and the ceramic is prepared in a conventional ceramic preparation method. The prepared unleaded piezoelectric ceramic has a good sintering characteristic, the preparation process is simple and stable, the performance is excellent, and the unleaded piezoelectric ceramic can partially replace the conventional lead based piezoelectric ceramic to be used.

The present invention discloses an apparatus and method for treating perfluoro-compounds (PFCs). The method for treating PFCs includes: (a) decomposing PFCs and eliminating a first acid gas generated by the decomposition through a pre-cleaner; (b) filtering out dust particles from the exhaust gas through a filter; (c) electrifying the dust particles in the exhaust gas by electrical discharge and collecting dusts through a dust collector; (d) decomposing PFCs using a regenerative/catalytic reaction through a catalytic reactor; (e) eliminating a second acid gas generated by the regenerative/catalytic reaction through a post-cleaner; and (f) letting the purified exhaust gas out through a fan.

A compound that emits fluorescence and delayed fluorescence is provided as a material for an organic electroluminescent device of high efficiency, and an organic photoluminescent device and an organic electroluminescent device of high efficiency and high luminance are provided using this compound. The compound of a general formula (1) having a triphenylene ring structure is used as a constituent material of at least one organic layer in the organic electroluminescent device that includes a pair of electrodes, and one or more organic layers sandwiched between the pair of electrodes.

The invention discloses a wood preservative containing a compound SchiglautoneA. The wood preservative comprises SchiglautoneA and Pingbeimine C in a ratio of weight by parts of 1:1 to 30: 1. By combining the SchiglautoneA and the Pingbeimine C in a specific proportion, the wood preservative has a good wood mildewproof effect.

Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R¹, L¹, L², L³, A¹, A², A³, A⁴, G¹, G², E, W, X, Y, Z, m, and n are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Innovative blender works with two rotors that each one is connected to an impeller. The rotors rotate contrary and transfer energy with two concentric axes configured of a shaft and a casing. The dual rotor causes fluid to be mixed completely without any swirling, drag or vortex, and this caused high agitation of fluid with high efficiency. The main reason for use of such blenders could include: household uses, laboratories, research centers, educational facilities, industries, water and wastewater treatment plants and anywhere that chemical compounds are mixed with fluids such as water or gases rapidly having short agitation time, in either low or high volumes.

An objective of the present invention is to provide carbapenem derivatives which have strong antibiotic activity also against MRSA, PRSP, Influenzavirus, and β-lactamase producing bacteria and are stable to DHP-1. The carbapenem derivatives according to the present invention are compounds represented by formulae (I) and (II) or pharmaceutically acceptable salts thereof:

wherein R¹ represents H or methyl, R² and R³ each independently represent H; halogen; substituted or unsubstituted alkyl; cycloalkyl; substituted or unsubstituted alkylcarbonyl; carbamoyl; substituted or unsubstituted aryl; substituted or unsubstituted alkylthio; morpholinyl; alkylsulfonyl; or formyl, n is 0 (zero) to 4, and Hy represents a substituted or unsubstituted monocyclic or bicyclic heterocyclic group.

Parts of compounds, after being labeled by radionuclide, of the phenyl benzyl ether derivative, are used as Aβ plaque imaging agent. The structural formula of the phenyl benzyl ether derivative is shown by formula (I). The present invention develops a kind of brand new phenyl benzyl ether derivative which has high affinity with Aβ plaques in brains of AD patients. The chemical structure of the phenyl benzyl ether derivative is different from that of compounds disclosed in the prior art and the phenyl benzyl ether derivative belongs to a brand new compound for diagnosing and treating AD. The obtained Aβ plaque imaging agent has the advantages that the in-vivo stability is good, the fat solubility is low, the removal speed for the brain is fast, the problem of removing the radionuclide in vivo does not exist, and the application prospect and the market value are great.

An object of the present invention is to provide a kit, a method, and a reagent which prevent the problem of false positive due to nonspecific adsorption, suppress the increase in noise to be generated, and are capable of achieving high-precision measurement of a measurement target substance in a wide concentration range from a low concentration to a high concentration. According to the present invention, there is provided a kit for measuring a measurement target substance, the kit including: a first particle having a label and modified with a first binding substance capable of specifically binding to a measurement target substance; a second particle having no label and modified with a second binding substance incapable of specifically binding to the measurement target substance; a flow channel for flowing the first particle and the second particle; and a substrate having a third binding substance capable of specifically binding to the measurement target substance or a substance capable of binding to the first binding substance, in which the first particle having a label is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle.

Each symbol in Formula (1) has the meaning described in the present specification.

The invention provides a polymer micelle carrying coenzyme Q10 series compounds, and a preparation method and a purpose of the polymer micelle, and belongs to the field of a biomedical material. The polymer micelle is prepared from coenzyme Q10 series compounds and amphiphilic block copolymers as raw materials. The mass ratio of the amphiphilic block copolymers to the coenzyme Q10 series compoundsis 0.1 to 100. The polymer micelle carrying coenzyme Q10 series compounds has the advantages that the solubility of the coenzyme Q10 series compounds in the water is obviously improved; the encapsulation efficiency is high; and the stability is high. The polymer micelle carrying coenzyme Q10 series compounds has the most significant characteristics that the skin permeability is obviously improvedand is superior to that in the prior art; and the polymer micelle carrying coenzyme Q10 series compounds can be used for transdermal administration. Meanwhile, the polymer micelle has low toxic and side effects, high safety and good application prospects.

The invention discloses an oleanolic acid oxime ester derivative and a preparation method and application thereof. According to the invention, oleanolic acid is taken as a raw material, a series of derivatives are synthesized through oxime esterification, lead compounds with good biological activity are obtained, and the synthesized OA derivative shows a glycosidase inhibition effect far higher than that of OA and has important biological activity. The oleanolic acid (OA) oxime ester derivative has a remarkable inhibition effect on the activity of alpha-glucosidase and alpha-amylase, the inhibition effect of the compound 3a on the alpha-glucosidase is the strongest, and IC50 is 0.35 mu M and is about 1900 times stronger than that of acarbose; the compound 3f has the strongest inhibition effect on alpha-amylase, and IC50 is 3.80 mu M and is about 26 times higher than acarbose. Researches show that the oleanolic acid oxime ester derivatives have reversible inhibition mechanisms and mixed inhibition mechanisms on alpha-glucosidase and alpha-amylase respectively.

The invention relates to a chromatography material, in particular a novel affine thiophilic silicon ball chromatography material and a preparation method and application thereof. The preparation method includes the steps that under existence of strong base, sulfamide, tri (2,3-expoxy propyl) isocyanate (TEPIC) and an aminated silicon ball shown in the formula I are subjected to co-polymerization in first organic solvent to prepare a co-polymerized material shown in the specification. The novel affine thiophilic silicon ball chromatography material is high in mechanical performance, easy to store, good in dispersion and capable of having good specificity enriching and separating capacity for a compound containing disulfide bonds. In addition, the preparation method is simple in step, raw materials are easy to obtain, the reaction process is controllable, and application and popularization are quite easy.

An ester compound represented by the formula (1):

has excellent pest controlling activity and is useful as an active ingredient for a pest controlling agent.

The invention provides a roxadustat intermediate impurity compound as well as a preparation method and application thereof, and belongs to the technical field of medicine synthesis. The structure of the compound is represented by a formula I. The preparation method comprises the preparation steps: 1, taking a compound II as a raw material, dissolving the compound II in a solvent, and obtaining a crude compound I under the action of inorganic alkali; and 2, recrystallizing the obtained crude product of the compound I to obtain the purified impurity compound I. The invention also discloses an impurity reference substance for the quality research of the rosaxostat intermediate, the impurity content in the rosaxostat intermediate can be effectively and conveniently monitored, and the quality of the rosaxostat intermediate is favorably controlled.

The invention provides a green solid defoaming agent and a preparation method thereof. The defoaming agent is characterized in that the green solid defoaming agent product is prepared by adopting natural grease as a defoaming active component, a mineral compound and a biological compound as carriers and polyglycerol as a structuring agent through a technological means of atom economy. The preparation method of the green solid defoaming agent comprises the following steps: (1) adding the carrier into a mixer M1, and uniformly stirring; (2) adding the defoaming active component and the structuring agent into a mixer M2 at the same time, and uniformly stirring; (3) adding the mixture in the step (2) into the mixer M1, and uniformly stirring; and (4) crushing or granulating the mixture obtained in the step (3) to obtain a mixture which is the prepared green solid defoaming agent. The green solid defoaming agent disclosed by the invention is green and environment-friendly, can realize biodegradation, and has relatively strong foam elimination and inhibition performance and anti-attenuation performance.

The invention provides a preparation method of Vonoprazan fumarate, and belongs to the field of medicine synthesis. According to the synthesis process route disclosed by the invention, the compounds which are easy to obtain in the market and low in price are used as raw materials, the reaction conditions are mild, the selectivity is high, the used reagents are few, the post-treatment is simple, the high-purity and high-yield product can be stably obtained, and the Vonoprasone fumarate is stably supplied.