Polymer micelle carrying coenzyme Q10 series compounds, and preparation method and purpose of polymer micelle

A polymer glue and compound technology, applied in the field of biomedical materials, can solve the problems of poor solubility of coenzyme Q10, poor stability in water, irritation of large blood vessels, etc., and achieve the effect of improving skin permeability, good stability, and less toxic side effects

Pending Publication Date: 2020-08-14
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows small molecules called Co-Q10. These tiny particles carry these substances throughout their body without being dissolved or losing them altogether during use. They are more stable when they're stored dry compared with other methods like liquid nitrogen storage (liquid) that require specialized equipment such as cryogenic temperatures. Overall this new method provides improved bioavailibility, protection against decomposition, ease of handling, and reduced harmfulness over existing ways of delivering drugs through skin barriers.

Problems solved by technology

This patented technical problem addressed in this patent relates to developing new types of substances called coenzzymes that could help fight against diseases like cardiovascular illness, arterioscholar stenosis, hyperlipidemma, tissue degenerative processes caused by inflammation, tumors, necrotic retinal pigments, cerebral infarct, stroke, depression, anxiety, sleep apnea syndrome, menopausa bleeding, Parkinsonism, Alzheimer' s Dementia, multiple organ failure symptoms associated therewith severe conditions including death due to lack of effective therapy options.

Method used

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  • Polymer micelle carrying coenzyme Q10 series compounds, and preparation method and purpose of polymer micelle
  • Polymer micelle carrying coenzyme Q10 series compounds, and preparation method and purpose of polymer micelle
  • Polymer micelle carrying coenzyme Q10 series compounds, and preparation method and purpose of polymer micelle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1, the preparation of polymer micelle loaded with coenzyme Q10 of the present invention

[0047] Coenzyme Q10, one of the coenzyme Q101 series compounds, and monomethyl ether polyethylene glycol-polycaprolactone block copolymer (MPEG2k-PCL2k, structural formula and 1 HNMR spectrum such as figure 1As shown, the weight-average molecular weight of the MPEG part is 2000, and the weight-average molecular weight of the PCL part is also 2000) placed in an eggplant-shaped bottle according to a mass ratio of 1:10, added methanol to dissolve completely, and then rotated on a rotary evaporator with a water bath temperature of 50 ° C. All the organic solvent was distilled off to obtain a thin film. Add water for injection (every 40mg MPEG2k-PCL2k adds 1mL water for injection), then heat in a water bath at 50°C, and spin the film for hydration for 30 minutes (rotation speed is 100rpm during spin hydration), to obtain a micellar solution with light yellow opalescence ( fres

Embodiment 2

[0051] Example 2, Preparation of Idebenone-loaded polymer micelles of the present invention

[0052] Idebenone, one of the coenzyme Q10 series compounds, and monomethyl ether polyethylene glycol-polylactic acid block copolymer (MPEG2k-PDLLA2k, the weight average molecular weight of the MPEG part is 2000, and the weight average molecular weight of the PDLLA part is also 2000) Put it in an eggplant-shaped bottle according to the mass ratio of 1:30, add methanol to dissolve completely, and then remove all organic solvents by rotary evaporation on a rotary evaporator at a water bath temperature of 50°C to obtain a thin film. Add water for injection (1 mL water for injection per 60 mg PEG2k-PDLLA2k). Then heated in a water bath at 30° C., and the film was hydrated by rotation for 30 minutes (the rotation speed during the rotation hydration was 100 rpm), and a micellar solution with light yellow opalescence was obtained. Filter through a 0.22 μm filter membrane, dispense 2 mL into via

Embodiment 3

[0053] Example 3, Preparation of Idebenone-loaded polymer micelles of the present invention

[0054] Idebenone, one of the coenzyme Q10 series compounds, and monomethyl ether polyethylene glycol-phospholipid block polymer (MPEG2k-PE2k, the weight average molecular weight of the MPEG part is 2000, and the weight average molecular weight of the PE part is also 2000) according to Mass ratio 1:20 was placed in an eggplant-shaped bottle, methanol was added to dissolve completely, and then all organic solvents were removed by rotary evaporation on a rotary evaporator at a water bath temperature of 50°C to obtain a thin film. Add water for injection (1 mL water for injection per 40 mg MPEG2k-PE2k). Then heated in a water bath at 30° C., and the film was hydrated by rotation for 30 minutes (the rotation speed during the rotation hydration was 100 rpm), and a micellar solution with light yellow opalescence was obtained. Filter through a 0.22 μm filter membrane, dispense 2 mL into vials,

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Abstract

The invention provides a polymer micelle carrying coenzyme Q10 series compounds, and a preparation method and a purpose of the polymer micelle, and belongs to the field of a biomedical material. The polymer micelle is prepared from coenzyme Q10 series compounds and amphiphilic block copolymers as raw materials. The mass ratio of the amphiphilic block copolymers to the coenzyme Q10 series compoundsis 0.1 to 100. The polymer micelle carrying coenzyme Q10 series compounds has the advantages that the solubility of the coenzyme Q10 series compounds in the water is obviously improved; the encapsulation efficiency is high; and the stability is high. The polymer micelle carrying coenzyme Q10 series compounds has the most significant characteristics that the skin permeability is obviously improvedand is superior to that in the prior art; and the polymer micelle carrying coenzyme Q10 series compounds can be used for transdermal administration. Meanwhile, the polymer micelle has low toxic and side effects, high safety and good application prospects.

Description

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Claims

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Application Information

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Owner WEST CHINA HOSPITAL SICHUAN UNIV
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